Results 91 to 100 of about 40,543 (253)

Stress Increases Vulnerability to Inflammation in the Rat Prefrontal Cortex [PDF]

open access: yes, 2006
Inflammation could be involved in some neurodegenerative disorders that accompany signs of inflammation. However, because sensitivity to inflammation is not equal in all brain structures, a direct relationship is not clear.
Argüelles Castilla, Sandro   +5 more
core   +1 more source

Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia

open access: yesBritish Journal of Haematology, EarlyView.
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Yuanyuan Xue   +10 more
wiley   +1 more source

BDNF Differentially Affects Low- and High-Frequency Neurons in a Primary Nucleus of the Chicken Auditory Brainstem

open access: yesBiology
Neurotrophins are proteins that mediate neuronal development using spatiotemporal signaling gradients. The chicken nucleus magnocellularis (NM), an analogous structure to the mammalian anteroventral cochlear nucleus, provides a model system in which ...
Kristine McLellan   +5 more
doaj   +1 more source

Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons [PDF]

open access: yes, 2018
Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fasciculus (MLF), and neurons in the lateral vestibular nucleus, whose axons project through the ascending tract ...
Benítez Temiño, Beatriz   +5 more
core   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

open access: yesBritish Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

p75NTR Modulation Reduces Oxidative Stress and the Expression of Pro-Inflammatory Mediators in a Cell Model of Rett Syndrome

open access: yesBiomedicines
Background: Rett syndrome (RTT) is an early-onset neurological disorder primarily affecting females, leading to severe cognitive and physical disabilities.
Michela Varone   +7 more
doaj   +1 more source

Tyrosine kinase A, C and fibroblast growth factor-2 receptors in bovine embryos cultured in vitro [PDF]

open access: yes, 2013
Neurotrophins and basic fibroblast growth factor are ligands of tyrosine kinase receptors, though they bind to different tyrosine kinase receptor classes.
Caamaño, J.N. (José)   +8 more
core  

Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection [PDF]

open access: yes, 2004
Streptococcus pneumoniae is an important human pathogen responsible for high mortality and morbidity worldwide. The susceptibility to pneumococcal infections is controlled by as yet unknown genetic factors.
Jonczyk, Magda S.   +7 more
core   +5 more sources

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Expression of NGF, BDNF and their receptors in subcutaneous adipose tissue of lactating cows [PDF]

open access: yes, 2015
Currently, there are no reports of neurotrophins in adipose tissue of cows. The distribution of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and their high-affinity tyrosine kinase receptors TrkA and TrkB, was investigated by ...
Colitti, Monica   +2 more
core   +1 more source

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