Neurodevelopmental disorders modeling using isogeometric analysis, dynamic domain expansion and local refinement [PDF]
arXivNeurodevelopmental disorders (NDDs) have arisen as one of the most prevailing chronic diseases within the US. Often associated with severe adverse impacts on the formation of vital central and peripheral nervous systems during the neurodevelopmental process, NDDs are comprised of a broad spectrum of disorders, such as autism spectrum disorder ...
arxiv
In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
Epilepsia, EarlyView.Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik +5 more
wiley +1 more source
Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine [PDF]
, 1994 Mathew T. Martin‐Iverson +2 more
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Epilepsia, EarlyView.Abstract Objective KCNB1 encodes an α‐subunit of the delayed‐rectifier voltage‐dependent potassium channel Kv2.1. De novo pathogenic variants of KCNB1 have been linked to developmental and epileptic encephalopathies (DEEs), diagnosed in early childhood and sharing limited treatment options.
Lauralee Robichon +7 more
wiley +1 more source
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression. [PDF]
, 1992 Eva M. Eves +5 more
openalex +1 more source
The universal role of adaptive transcription in health and disease
The FEBS Journal, EarlyView.Adaptive transcription via molecules such as CREB, MEF2, SRF, AP1, Nr4a1, and Egr1 constitutes a universal mechanism for directed cell state transitions in health and disease. These molecules are involved in physiological adaptation processes, pathological maladaptations, curative adaptations, and development of resistance to treatment.
Thomas Lissek
wiley +1 more source
Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons [PDF]
, 1993 Alun M. Davies +5 more
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3D neuron growth and neurodevelopmental disorder modeling based on truncated hierarchical B-splines with multi-level local refinements [PDF]
arXiv3D neuron growth and neurodevelopmental disorders (NDDs) deterioration exhibit complex morphological transformations as neurites differentiate into axons and dendrites, forming intricate networks driven by tubulin concentrations and neurotrophin signals.
arxiv
d‐amino acids: new functional insights
The FEBS Journal, EarlyView.This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni +5 more
wiley +1 more source
eLife, 2016 Brain and spinal injury reduce mobility and often impair sensorimotor processing in the spinal cord leading to spasticity. Here, we establish that complete transection of corticospinal pathways in the pyramids impairs locomotion and leads to increased ...
Claudia Kathe +3 more
doaj +1 more source