Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source
PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination. [PDF]
, 2019 Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and loss of bladder, bowel, and sexual function.
Anderson, Aileen J +8 more
core +1 more source
Neurotrophins and Neurotrophin Receptors in Proliferative Diabetic Retinopathy [PDF]
PLoS ONE, 2013 Neurotrophins (NTs) are emerging as important mediators of angiogenesis and fibrosis. We investigated the expression of the NTs nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) and their receptors TrkA, TrkB, and TrkC in proliferative diabetic retinopathy (PDR).
Abu El-Asrar, Ahmed M. +8 more
openaire +5 more sources
Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]
, 2001 Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P +3 more
core +1 more source
Neurotrophins and hyperalgesia [PDF]
Proceedings of the National Academy of Sciences, 1999 Nerve growth factor (NGF), a member of the neurotrophin family, is crucial for survival of nociceptive neurons during development. Recently, it has been shown to play an important role in nociceptive function in adults. NGF is up-regulated after inflammatory injury of the skin.
Lorne M. Mendell, X.-Q. Shu
openaire +3 more sources
Neurotrophins BDNF and NT4/5 accelerate dental pulp stem cell migration
Biomedical Journal, 2021 Neurotrophic factors play important roles in neuron survival, growth and differentiation. In the present research, the expression of multiple neurotrophins and their effects on cell migration were studied in the dental pulp stem cells (DPSCs).
Nan Xiao, Der Thor, Wei Ye Yu
doaj
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
core +1 more source
Nerves in the Tumor Microenvironment: Origin and Effects
Frontiers in Cell and Developmental Biology, 2020 Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and metastasis.
Wenjun Wang +7 more
doaj +1 more source
Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]
, 2015 The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA +2 more
core +2 more sources
Current Allergy and Asthma Reports, 2018 Asthma is a chronic airway disease that affects more than 300 million people worldwide. Current treatment focuses on symptomatic relief by temporally dampening inflammation and relaxing the airway. Novel combative strategies against asthma and hopefully a cure are yet to be developed.
Juliana Barrios, Xingbin Ai
openaire +3 more sources