Results 41 to 50 of about 44,486 (289)
Cellular and molecular mechanisms of perineural invasion of pancreatic ductal adenocarcinoma
Cancer Communications, 2021 Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignant disease with a unique tumor microenvironment surrounded by an interlaced network of cancer and noncancerous cells.
Jingbo Li, Rui Kang, Daolin Tang
doaj +1 more source
Serum Level Changes of Neurotrophin-3 After Performing Diabetic Foot Exercise in Diabetic Neuropathy [PDF]
, 2015 The research aimed to determine the pattern of changes in serum levels of NT-3 in the improvement of diabetic neuropathy, after doing diabetic foot exercise. A true experimental study with randomaized pre – post test control trial. A total of 36 subjects
Pranoto, A. (Agung) +2 more
core +3 more sources
Frontiers in Molecular Neuroscience, 2017 Some therapeutic side-effects result from simultaneous activation of homolog receptors by the same ligand. Tropomyosin receptor kinases (TrkA, TrkB and TrkC) play a major role in the development and biology of neurons through neurotrophin signaling.
Yazan Haddad +5 more
doaj +1 more source
Neurotrophins as Therapeutic Agents for Parkinson’s Disease; New Chances From Focused Ultrasound?
Frontiers in Neuroscience, 2022 Magnetic Resonance–guided Focused Ultrasound (MRgFUS) represents an effective micro-lesioning approach to target pharmaco-resistant tremor, mostly in patients afflicted by essential tremor (ET) and/or Parkinson’s disease (PD).
Alessandro Stefani +9 more
doaj +1 more source
BDNF/TrkB axis activation promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis [PDF]
, 2017 Background: Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a possible role in lung health and ...
Bruno, Pierdonato +8 more
core +1 more source
A Single Aplysia Neurotrophin Mediates Synaptic Facilitation via Differentially Processed Isoforms
Cell Reports, 2013 Neurotrophins control the development and adult plasticity of the vertebrate nervous system. Failure to identify invertebrate neurotrophin orthologs, however, has precluded studies in invertebrate models, limiting our understanding of fundamental aspects
Stefan R. Kassabov +5 more
doaj +1 more source
Modulation of neurotrophic signaling pathways by polyphenols [PDF]
, 2015 Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza +3 more
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Activation of Trk neurotrophin receptors in the absence of neurotrophins [PDF]
Proceedings of the National Academy of Sciences, 2001 Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of Trk receptor tyrosine kinases. Binding of neurotrophins to Trk receptors results in receptor autophosphorylation and downstream phosphorylation cascades.
Francis S. Lee, Moses V. Chao
openaire +3 more sources
Neurotrophins induce fission of mitochondria along embryonic sensory axons
eLife, 2019 Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial
Lorena Armijo-Weingart +5 more
doaj +1 more source
Frontiers in Genetics, 2020 Major depressive disorder (MDD) is a heterogeneous psychiatric disease characterized by persistent low mood, diminished interests, and impaired cognitive and social functions.
Vincenzo Dattilo +6 more
doaj +1 more source