Results 21 to 30 of about 14,410 (259)

Insulin regulates neurovascular coupling through astrocytes

Proceedings of the National Academy of Sciences, 2022
Mice with insulin receptor (IR)–deficient astrocytes (GFAP-IR knockout [KO] mice) show blunted responses to insulin and reduced brain glucose uptake, whereas IR-deficient astrocytes show disturbed mitochondrial responses to glucose. While exploring the functional impact of disturbed mitochondrial function in astrocytes, we observed that ...
Ana M. Fernandez, Laura Martinez-Rachadell, Marta Navarrete, Julia Pose-Utrilla, Jose Carlos Davila, Jaime Pignatelli, Sonia Diaz-Pacheco, Santiago Guerra-Cantera, Emilia Viedma-Moreno, Rocio Palenzuela, Samuel Ruiz de Martin Esteban, Ricardo Mostany, Cristina Garcia-Caceres, Matthias Tschöp, Teresa Iglesias, Maria L. de Ceballos, Antonia Gutierrez, Ignacio Torres Aleman   +17 more
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Potassium Channels and Neurovascular Coupling

Circulation Journal, 2010
Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow.
Dunn, Kathryn M., Nelson, Mark T.
openaire   +3 more sources

Neurovascular coupling in the mammalian brain [PDF]

Experimental Physiology, 2007
Normal brain function requires proper supply of oxygen and glucose in a timely and local manner. This is achieved through an orchestrated intercellular communication between neurones, astrocytes and microvessels that results in a rapid and restricted increase in cerebral blood flow, a process known as neurovascular coupling.
Jessica A, Filosa, Víctor M, Blanco
openaire   +2 more sources

Neurovascular coupling unit dysfunction and dementia: Retinal measurements as tools to move towards population-based evidence

Frontiers in Endocrinology, 2022
Dysfunction of the neurovascular coupling unit may be an important contributor to dementia. The neurovascular coupling unit comprises neuronal structures (e.g. astrocytes) and vascular structures (e.g.
Frank C. T. van der Heide, Frank C. T. van der Heide, Frank C. T. van der Heide, Frank C. T. van der Heide, Thomas T. van Sloten, Thomas T. van Sloten, Nele Willekens, Nele Willekens, Coen D. A. Stehouwer, Coen D. A. Stehouwer   +9 more
doaj   +1 more source

Comparing dynamic causal models of neurovascular coupling with fMRI and EEG/MEG

NeuroImage, 2020
This technical note presents a dynamic causal modelling (DCM) procedure for evaluating different models of neurovascular coupling in the human brain – using combined electromagnetic (M/EEG) and functional magnetic resonance imaging (fMRI) data.
Amirhossein Jafarian, Vladimir Litvak, Hayriye Cagnan, Karl J. Friston, Peter Zeidman   +4 more
doaj   +1 more source

Role of Astrocytes in Neurovascular Coupling [PDF]

Neuron, 2011
Neural activity is intimately tied to blood flow in the brain. This coupling is specific enough in space and time that modern imaging methods use local hemodynamics as a measure of brain activity. In this review, we discuss recent evidence indicating that neuronal activity is coupled to local blood flow changes through an intermediary, the astrocyte ...
Petzold, Gabor C, Murthy, Venkatesh N
openaire   +2 more sources

Subarachnoid Hemorrhage, Spreading Depolarizations and Impaired Neurovascular Coupling

Stroke Research and Treatment, 2013
Aneurysmal subarachnoid hemorrhage (SAH) has devastating consequences on brain function including profound effects on communication between neurons and the vasculature leading to cerebral ischemia.
Masayo Koide, Inna Sukhotinsky, Cenk Ayata, George C. Wellman   +3 more
doaj   +1 more source

Disturbed neurovascular coupling in type 2 diabetes mellitus patients: Evidence from a comprehensive fMRI analysis

NeuroImage: Clinical, 2019
Background: Previous studies presumed that the disturbed neurovascular coupling to be a critical risk factor of cognitive impairments in type 2 diabetes mellitus (T2DM), but distinct clinical manifestations were lacked.
Bo Hu, Lin-Feng Yan, Qian Sun, Ying Yu, Jin Zhang, Yu-Jie Dai, Yang Yang, Yu-Chuan Hu, Hai-Yan Nan, Xin Zhang, Chun-Ni Heng, Jun-Feng Hou, Qing-Quan Liu, Chang-Hua Shao, Fei Li, Kai-Xiang Zhou, Hang Guo, Guang-Bin Cui, Wen Wang   +18 more
doaj   +1 more source

Altered Neurovascular Coupling in Unilateral Pulsatile Tinnitus

Frontiers in Neuroscience, 2022
ObjectiveAltered cerebral blood flow (CBF) and regional homogeneity (ReHo) have been reported in pulsatile tinnitus (PT) patients. We aimed to explore regional neurovascular coupling changes in PT patients.Materials and MethodsTwenty-four right PT ...
Xiaoshuai Li, Ning Xu, Chihang Dai, Xuxu Meng, Xiaoyu Qiu, Heyu Ding, Rong Zeng, Han Lv, Pengfei Zhao, Zhenghan Yang, Shusheng Gong, Zhenchang Wang   +11 more
doaj   +1 more source

Functional Brain Imaging Based on the Neurovascular Unit for Evaluating Neural Networks after Strok [PDF]

Advanced Ultrasound in Diagnosis and Therapy, 2022
The exploration of human brain function has always been a research hotspot in the field of neuroscience. The concept of a neurovascular unit suggests that cerebral microcirculation can be used as a reliable signal to reflect neural function. Accordingly,
Yongyue Zhang, MM, Yang Sun, MM, Li Zhang, MM, Rongjin Zhang, MM, Shumin Wang, PhD
doaj   +1 more source