Results 51 to 60 of about 14,410 (259)

Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling

Frontiers in Cellular Neuroscience, 2015
Neuronal activity must be tightly coordinated with blood flow to keep proper brain function, which is achieved by a mechanism known as neurovascular coupling. Then, an increase in synaptic activity leads to a dilation of local parenchymal arterioles that
Manuel Francisco Muñoz, Mariela ePuebla, Xavier eFigueroa   +2 more
doaj   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to poor ...
Christian Staehr, John T. Giblin, Eugenio Gutiérrez‐Jiménez, Halvor Ø. Guldbrandsen, Jianbo Tang, Shaun L. Sandow, David A. Boas, Vladimir V. Matchkov   +7 more
doaj   +1 more source

An In Situ Embedded B‐MOF Sponge With Shape‐Memory for All‐in‐One Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
A smart shape‐memory sponge dressing (P1A3@B‐MOF) is developed for accelerated diabetic wound healing. It achieves pH‐responsive corelease of Zn2+ and salvianolic acid B, synergistically providing antibacterial action, repolarizing macrophages to the M2 phenotype, and promoting angiogenesis.
Hai Zhou, Chaoyang Huang, Yanqi Chen, Tingzi Zhao, Fengyi Zhu, Gong Jun, Jinrong Zhang, Yingsong Pan, Qiulan Wen, Lei Yang, Huihui Zhang, Lianglong Chen   +11 more
wiley   +1 more source

Cortical specificity in neurovascular coupling

Journal of Neurophysiology, 2015
Despite mounting contrary evidence, the metabolic hypothesis is viewed as the predominant theory underlying neurovascular coupling, or the link between neural activity and cerebral blood flow. In a recent study, Huo et al. (Huo BX, Smith JB, Drew PJ.
openaire   +4 more sources

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Advances in the study of neurovascular coupling in bone repair

Shanghai Jiaotong Daxue xuebao. Yixue ban
Bone repair is a complex physiological process. The nerves within the bone can regulate bone tissue regeneration through the secretion of bioactive factors and interactions with cells within the bone. Recent studies have sought to leverage the principles
HE Shuhang, GUO Shangchun, TAO Shicong
doaj   +1 more source

Modeling the relationship between neuronal activity and the BOLD signal: contributions from astrocyte calcium dynamics

Scientific Reports, 2023
Functional magnetic resonance imaging relies on the coupling between neuronal and vascular activity, but the mechanisms behind this coupling are still under discussion.
Federico Tesler, Marja-Leena Linne, Alain Destexhe   +2 more
doaj   +1 more source

High-resolution in vivo imaging of rhesus cerebral cortex with ultrafast portable photoacoustic microscopy

NeuroImage, 2021
Revealing the structural and functional change of microvasculature is essential to match vascular response with neuronal activities in the investigation of neurovascular coupling. The increasing use of rhesus models in fundamental and clinical studies of
Wei Qin, Qi Gan, Lei Yang, Yongchao Wang, Weizhi Qi, Bowen Ke, Lei Xi   +6 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source