Results 21 to 30 of about 38,595 (171)

Hydrolysis of rat melanin-concentrating hormone by endopeptidase 24.11 (neutral endopeptidase) [PDF]

open access: yesBiochemical Journal, 1992
Melanin-concentrating hormone (MCH) is a cyclic peptide which behaves as an antagonist of the pituitary melanotropic hormone alpha-melanocyte-stimulating hormone in fishes. Cloning of the rat MCH cDNA precursor recently revealed the presence of an additional putative peptide named NEI.
F, Checler   +4 more
openaire   +2 more sources

Primary Membranous Glomerulonephritis: The Role of Serum and Urine Biomarkers in Patient Management

open access: yesBiomedicines, 2019
The detection of phospholipase A2 receptor (PLA2R) and thrombospondin domain containing 7A THSD7A among primary membranous glomerulonephritis (MGN) patients transformed the diagnosis, treatment monitoring, and prognosis. Anti-PLA2R can be detected in 70&#
Sadiq Mu’azu Maifata   +3 more
doaj   +1 more source

Hydrogen Peroxide Inhibits Lung Neutral Endopeptidase

open access: yesExperimental Lung Research, 1995
Oxidants have been implicated in the pathogenesis of many inflammatory airway diseases. Neutral endopeptidase (also called enkephalinase, EC 3.4.24.11) is a peptidase that is involved in the degradation of several proinflammatory peptides, such as tachykinins and kinins.
G L, Roisman, D J, Dusser
openaire   +2 more sources

A pathogenic variant (c.1483-1G>C) in a Korean patient with X-linked hypophosphatemic rickets [PDF]

open access: yesAnnals of Pediatric Endocrinology & Metabolism, 2021
X-linked hypophosphatemic rickets is an X-linked dominantly inherited disorder characterized by defects in renal phosphate transport leading to phosphate wasting and hypophosphatemia.
In Hwa Jeong, Jae-Ho Yoo, Namhee Kim
doaj   +1 more source

Role of neutral endopeptidase in endotoxin-induced bronchial hyperresponsiveness to substance P in guinea pigs

open access: yesAllergology International, 1998
To investigate effects of endotoxin on allergic airway diseases, we studied bronchial responsiveness to histamine (HI) and substance P (SP) in actively sensitized and non-sensitized guinea pigs 24 h after exposure to endotoxin (75 (μg/mL; 40 min) and its
Shigenori Iwamae   +4 more
doaj   +1 more source

A new brain metalloendopeptidase which degrades the Alzheimer ß-amyloid 1-40 peptide producing soluble fragments without neurotoxic effects

open access: yesBrazilian Journal of Medical and Biological Research, 1997
A new metalloendopeptidase was purified to apparent homogeneity from a homogenate of normal human brain using successive steps of chromatography on DEAE-Trisacryl, hydroxylapatite and Sephacryl S-200.
K.M. Carvalho   +3 more
doaj   +1 more source

Local renin angiotensin system and sperm DNA fragmentation

open access: yesAsian Journal of Andrology, 2022
The renin angiotensin system (RAS) appears to influence male fertility at multiple levels. In this work, we analyzed the relationship between the RAS and DNA integrity.
María Victoria Aparicio Prieto   +6 more
doaj   +1 more source

Amyloid/Melanin distinctive mark in invertebrate immunity [PDF]

open access: yesInvertebrate Survival Journal, 2012
Protostomes and Deuterostomes show the same nexus between melanin production, and amyloid fibril production, i.e., the presence of melanin is indissolubly linked to amyloid scaffold that, in turn, is conditioned by the redox status/cytoplasmic pH ...
A Grimaldi   +7 more
doaj   +1 more source

Role of endothelial cells and angiotensin converting enzyme-II in COVID-19 and brain damages post-infection

open access: yesFrontiers in Neurology, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) causes coronavirus disease 2019 (COVID-19), which became a pandemic in late 2019 and early 2020.
Riffat Mehboob   +5 more
doaj   +1 more source

Supramolecular complex sacubitril/valsartan - the first representative of a new class of drugs for the treatment of chronic heart failure

open access: yesPatologìâ, 2019
The average prevalence of сhronic heart failure in the adult population, according to the statistics of different countries, ranges from 1.5 % to 5.5 % and therefore the study of this problem and of finding new approaches to the treatment of сhronic ...
T. V. Ashcheulova   +2 more
doaj   +1 more source

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