Results 1 to 10 of about 441,679 (347)

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

bioRxiv, 2021
SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein.
C. K. Wibmer, F. Ayres, T. Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, B. Lambson, M. Vermeulen, Karin van den Berg, T. Rossouw, M. Boswell, V. Ueckermann, S. Meiring, A. von Gottberg, C. Cohen, L. Morris, J. Bhiman, P. Moore   +16 more
semanticscholar   +1 more source

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Nature, 2021
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections1.
S. Cele, Laurelle Jackson, D. Khoury, K. Khan, T. Moyo-Gwete, H. Tegally, J. E. San, D. Cromer, C. Scheepers, D. Amoako, F. Karim, M. Bernstein, G. Lustig, D. Archary, Muneerah Smith, Y. Ganga, Z. Jule, K. Reedoy, Shi-Hsia Hwa, J. Giandhari, J. Blackburn, B. Gosnell, S. A. Abdool Karim, W. Hanekom, Mary-Ann Marvin Darren Koleka Constantinos Kurt Carolyn Den Davies Hsiao Martin Mlisana Wibmer Williamson York, M. Davies, M. Hsiao, Darren P. Martin, K. Mlisana, C. K. Wibmer, C. Williamson, Denis York, Rohen Kobus Prakash Thandeka Henrik Alasdair Rajhmun Nom Harrichandparsad Herbst Jeena Khoza Kløverpris Les, Rohen Harrichandparsad, K. Herbst, P. Jeena, Thandeka Khoza, H. Kløverpris, A. Leslie, R. Madansein, N. Magula, N. Manickchund, Mohlopheni J. Marakalala, M. Mazibuko, M. Moshabela, N. Mthabela, K. Naidoo, Z. Ndhlovu, T. Ndung’u, Nokuthula Ngcobo, K. Nyamande, Vinod B Patel, T. Smit, A. Steyn, E. Wong, A. von Gottberg, J. Bhiman, R. Lessells, M. S. Moosa, M. Davenport, Tulio de Oliveira, P. Moore, A. Sigal   +62 more
semanticscholar   +1 more source

Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera

Nature Network Boston, 2021
We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA.
Xuping Xie, Yang Liu, Jianying Liu, Xianwen Zhang, Jing Zou, Camila R. Fontes-Garfias, Hongjie Xia, K. Swanson, Mark Cutler, David Cooper, Vineet D. Menachery, S. Weaver, P. Dormitzer, P. Shi   +13 more
semanticscholar   +2 more sources

Neutrality in the Metaorganism [PDF]

PLOS Biology, 2018
AbstractAlmost all animals and plants are inhabited by diverse communities of microorganisms, the microbiota, thereby forming an integrated entity, the metaorganism. Natural selection should favor hosts that shape the community composition of these microbes to promote a beneficial host-microbe symbiosis.
Benedikt M Mortzfeld, Nancy Weiland-Bräuer, Jun Wang, Hinrich Schulenburg, Hinrich Schulenburg, Philipp Dirksen, Philipp Dirksen, Ruth A. Schmitz, Thomas C. G. Bosch, Sebastian Fraune, John F. Baines, John F. Baines, Sören Franzenburg, Michael Sieber, Lucía Pita, Ute Hentschel, Ute Hentschel, Arne Traulsen   +17 more
openaire   +7 more sources

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera

Science, 2021
Vaccine protects against B1.1.7 variant The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B1.1.7 (VOC 202012/01) variant that emerged in late 2020 in the United Kingdom has many changes in the spike protein gene.
A. Muik, A. Wallisch, Bianca Sänger, K. Swanson, Julia Mühl, Wei Chen, Hui Cai, D. Maurus, Ritu Sarkar, Ö. Türeci, P. Dormitzer, U. Şahin   +11 more
semanticscholar   +1 more source

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

Nature Network Boston, 2022
The emergence of the highly transmissible B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is concerning for antibody countermeasure efficacy because of the number of mutations in the spike protein. In this study,
L. VanBlargan, J. Errico, P. Halfmann, Seth J. Zost, J. Crowe, L. Purcell, Y. Kawaoka, D. Corti, D. Fremont, M. Diamond   +9 more
semanticscholar   +1 more source

Neutralization of SARS-CoV-2 Omicron by BNT162b2 mRNA vaccine–elicited human sera

Science, 2022
The globally circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern Omicron (B.1.1.529) has a large number of mutations, especially in the spike protein, indicating that recognition by neutralizing antibodies may be ...
A. Muik, B. G. Lui, Ann-Kathrin Wallisch, Maren Bacher, Julia Mühl, J. Reinholz, O. Ozhelvaci, Nina Beckmann, Ramón de la Caridad Güimil Garcia, A. Poran, S. Shpyro, Andrew Finlayson, Hui Cai, Qi Yang, K. Swanson, Ö. Türeci, U. Şahin   +16 more
semanticscholar   +1 more source

Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization

bioRxiv, 2021
The relative resistance of SARS-CoV-2 variants B.1.1.7 and B.1.351 to antibody neutralization has been described recently. We now report that another emergent variant from Brazil, P.1, is not only refractory to multiple neutralizing monoclonal antibodies,
Pengfei Wang, R. Casner, M. Nair, Maple Wang, Jian Yu, G. Cerutti, Lihong Liu, P. Kwong, Yaoxing Huang, L. Shapiro, D. Ho   +10 more
semanticscholar   +1 more source

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Cell, 2021
Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants harboring mutations in spike, the main target of neutralizing antibodies. To understand the impact of
W. García-Beltrán, E. Lam, K. S. Denis, Adam D Nitido, Zeidy H. Garcia, B. Hauser, J. Feldman, Maia N Pavlovic, D. Gregory, M. Poznansky, A. Sigal, A. Schmidt, A. Iafrate, V. Naranbhai, A. Balazs   +14 more
semanticscholar   +1 more source

Third BNT162b2 Vaccination Neutralization of SARS-CoV-2 Omicron Infection

medRxiv, 2021
Using isolates of SARS-CoV-2 WT, Beta, Delta and most importantly Omicron we studied the capability of the BNT162b2 vaccine given in two or three doses to neutralize major SARS-CoV-2 variants of concern (VOC). We demonstrate low neutralization efficiency
I. Nemet, L. Kliker, Y. Lustig, N. Zuckerman, O. Erster, Carmit Cohen, Y. Kreiss, S. alroy-Preis, G. Regev-Yochay, E. Mendelson, M. Mandelboim   +10 more
semanticscholar   +1 more source