Results 31 to 40 of about 438,037 (298)

SARS-CoV-2 Neutralization with BNT162b2 Vaccine Dose 3

New England Journal of Medicine, 2021
To the Editor: We conducted a global, randomized, placebo-controlled, phase 1–2–3 pivotal trial in which two 30-μg doses of BNT162b2 (Pfizer–BioNTech) were administered 21 days apart (ClinicalTrials.gov number, NCT04368728).
A. Falsey, R. Frenck, E. Walsh, N. Kitchin, J. Absalon, A. Gurtman, S. Lockhart, R. Bailey, K. Swanson, Xia Xu, K. Koury, W. Kalina, David Cooper, Jing Zou, Xuping Xie, Hongjie Xia, Ö. Türeci, E. Lagkadinou, Kristin Tompkins, P. Shi, K. Jansen, U. Şahin, P. Dormitzer, W. Gruber   +23 more
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Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

bioRxiv, 2020
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity.
K. H. Crawford, Rachel T. Eguia, A. Dingens, Andrea N. Loes, Keara D. Malone, C. Wolf, H. Chu, M. A. Tortorici, D. Veesler, M. Murphy, D. Pettie, N. King, A. Balazs, J. Bloom   +13 more
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Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster

New England Journal of Medicine, 2022
To the Editor: The emergence of the highly divergent B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to concerns about the efficacy of vaccines based on the ancestral spike and to the approval in the United
Meredith E. Davis-Gardner, L. Lai, Bushra Wali, Hady Samaha, D. Solis, Matthew Lee, Andrea Porter-Morrison, I. T. Hentenaar, F. Yamamoto, Sucheta Godbole, Yuan Liu, D. Douek, F. Lee, N. Rouphael, Alberto Moreno, B. Pinsky, M. Suthar   +16 more
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Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2

Emerging Microbes and Infections, 2020
Pseudoviruses are useful virological tools because of their safety and versatility, especially for emerging and re-emerging viruses. Due to its high pathogenicity and infectivity and the lack of effective vaccines and therapeutics, live SARS-CoV-2 has to
J. Nie, Qian-qian Li, Jia-jing Wu, Chenyan Zhao, H. Hao, Huan Liu, Li Zhang, L. Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Qiyu Sun, Junkai Liu, Changfa Fan, Weijing Huang, Miao Xu, Youchun Wang   +17 more
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Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

Nature, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein substitution D614G became dominant during the coronavirus disease 2019 (COVID-19) pandemic1,2. However, the effect of this variant on viral spread and vaccine efficacy remains
Jessica A. Plante, Yang Liu, Jianying Liu, Hongjie Xia, Bryan A. Johnson, K. Lokugamage, Xianwen Zhang, Antonio E. Muruato, Jing Zou, Camila R. Fontes-Garfias, D. Mirchandani, Dionna Scharton, J. Bilello, Z. Ku, Z. An, Birte K. Kalveram, Alexander N. Freiberg, Vineet D. Menachery, Xuping Xie, K. Plante, S. Weaver, P. Shi   +21 more
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Recovery of lithium salt from spent lithium‐ion battery by less polar solvent wash and water extraction

Carbon Neutralization, 2023
The lithium hexafluorophosphate (LiPF6) in spent lithium‐ion batteries (LIBs) is a potentially valuable resource and a significant environmental pollutant. Unfortunately, most of the LiPF6 in a spent LIB is difficult to extract because the electrolyte is
Hao Du, Yuqiong Kang, Chenglei Li, Yun Zhao, Yao Tian, Jian Lu, Zhaoyang Chen, Ning Gao, Zhike Li, John Wozny, Tao Li, Li Wang, Naser Tavajohi, Feiyu Kang, Baohua Li   +14 more
doaj   +1 more source

Broad neutralization of SARS-related viruses by human monoclonal antibodies

Science, 2020
Seeking broad protection As scientists develop therapeutic antibodies and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the risk of emergent coronaviruses makes it important to also identify broadly protective antibodies.
Anna Z. Wec, D. Wrapp, A. Herbert, Daniel P. Maurer, Denise Haslwanter, M. Sakharkar, R. Jangra, M. Dieterle, A. Lilov, Deli Huang, Longping V. Tse, N. Johnson, C. Hsieh, Nianshuang Wang, J. Nett, E. Champney, Irina Burnina, Michael E. Brown, Shu Lin, M. Sinclair, Carl Johnson, Sarat Pudi, R. Bortz, A. Wirchnianski, Ethan Laudermilch, Catalina Florez, J. Fels, Cecilia M. O’Brien, B. Graham, D. Nemazee, D. Burton, R. Baric, J. Voss, K. Chandran, J. Dye, J. McLellan, L. Walker   +36 more
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Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation

medRxiv, 2021
We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 remnant nasal/nasopharyngeal swab samples from 44 counties in California. Named B.1.427/B.1.429 or 20C/L452R, the variant emerged around May 2020 and increased from 0% to >
Xianding Deng, M. Garcia-Knight, M. Khalid, V. Servellita, Candace Wang, M. Morris, A. Sotomayor-González, Dustin R. Glasner, Kevin R. Reyes, A. Gliwa, N. P. Reddy, Claudia Sanchez San Martin, S. Federman, Jing Cheng, J. Balcerek, Jordan Taylor, J. Streithorst, Steve Miller, G. R. Kumar, B. Sreekumar, Pei-Yi Chen, U. Schulze-Gahmen, T. Y. Taha, J. Hayashi, C. Simoneau, Sarah McMahon, Peter V. Lidsky, Yinghong Xiao, P. Hemarajata, N. Green, A. Espinosa, Chantha Kath, M. Haw, J. Bell, J. Hacker, C. Hanson, D. Wadford, C. Anaya, D. Ferguson, L. Lareau, Phillip A. Frankino, H. Shivram, S. Wyman, M. Ott, R. Andino, C. Chiu   +45 more
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Biochar‐based interfacial evaporation materials derived from lignosulfonate for efficient desalination

Carbon Neutralization, 2023
The solar‐driven interfacial evaporation has attracted great attention for the purpose of alleviating freshwater shortage. Lignosulfonate (LS), a main byproduct of sulfite pulping processes, is an abundant natural resource but has not been reasonably ...
Shilin Chen, Lan Sun, Yuqing Huang, Dongjie Yang, Mingsong Zhou, Dafeng Zheng   +5 more
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Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Nature Microbiology, 2021
Understanding the molecular basis for immune recognition of SARS-CoV-2 spike glycoprotein antigenic sites will inform the development of improved therapeutics. We determined the structures of two human monoclonal antibodies–AZD8895 and AZD1061–which form
Jinhui Dong, Seth J. Zost, Allison J. Greaney, Tyler N. Starr, A. Dingens, E. Chen, Rita E. Chen, J. Case, Rachel E. Sutton, P. Gilchuk, Jessica Rodriguez, Erica Armstrong, Christopher Gainza, Rachel S. Nargi, E. Binshtein, Xuping Xie, Xianwen Zhang, P. Shi, James Logue, S. Weston, M. McGrath, M. Frieman, Tyler Brady, K. Tuffy, H. Bright, Y. Loo, P. McTamney, M. Esser, R. Carnahan, M. Diamond, J. Bloom, J. Crowe   +31 more
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