Results 71 to 80 of about 454,570 (346)

Neutralization of SARS-CoV-2 variants by convalescent and BNT162b2 vaccinated serum

Nature Communications, 2021
SARS-CoV-2 and its variants continue to infect hundreds of thousands every day despite the rollout of effective vaccines. Therefore, it is essential to understand the levels of protection that these vaccines provide in the face of emerging variants. Here,
T. Bates, H. Leier, Zoe L. Lyski, Savannah K. McBride, Felicity J. Coulter, Jules B. Weinstein, James R Goodman, Zhengchun Lu, S. Siegel, Peter E Sullivan, Matt I Strnad, A. Brunton, D. X. Lee, Andrew C. Adey, B. Bimber, B. O’Roak, M. Curlin, W. Messer, F. Tafesse   +18 more
semanticscholar   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms

Frontiers in Immunology, 2023
HIV-1 infection of target cells can occur through either cell-free virions or cell-cell transmission in a virological synapse, with the latter mechanism of infection reported to be 100- to 1,000-fold more efficient.
Weiming Wang, Khanghy Truong, Chaobaihui Ye, Suman Sharma, Huan He, Lihong Liu, Michael Wen, Anisha Misra, Paul Zhou, Jason T. Kimata   +9 more
doaj   +1 more source

A single nanobody neutralizes multiple epochally evolving human noroviruses by modulating capsid plasticity [PDF]

, 2023
Wilhelm Salmen, Liya Hu, Marina Bok, Natthawan Chaimongkol, Khalil Ettayebi, Stanislav V. Sosnovtsev, Kaundal Soni, B. Vijayalakshmi Ayyar, Sreejesh Shanker, Frederick H. Neill, Banumathi Sankaran, Robert L. Atmar, Mary K. Estes, Kim Y. Green, Viviana Parreño, B. V. Venkataram Prasad   +15 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Crystallization kinetics‐driven defect landscape in wide‐bandgap perovskite solar cells: Mechanistic elucidation and multiscale regulation strategies

Information & Functional Materials
Wide‐bandgap perovskite solar cells (WBG‐PSCs) are the core devices to break through the efficiency limit of single junction cells by constructing tandem devices.
Luozheng Zhang, Yi Zhang, Liguo Wang, Zhimin Fang, Bairu Li, Yufei Zhong, Shen Xing, Jianning Ding   +7 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Revisiting the critical role of metallic ash elements in the development of hard carbon for advancing sodium-ion battery applications

eScience
Hard carbon (HC) anodes in sodium-ion batteries (SIBs) are prized for their high capacity, durability, cost-efficiency, environmental sustainability, and safety. The metallic ash elements in HCs inevitably affect the overall performance of SIBs, however,
Chun Wu, Wenjie Huang, Yinghao Zhang, Qinghang Chen, Li Li, Yajun Zhang, Xingqiao Wu, Shu-Lei Chou   +7 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source