Results 131 to 140 of about 754,642 (308)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Performance evaluation of four kits for the detection of neutralizing antibody against SARS-CoV-2 in human serum

Journal of Clinical Virology Plus
To evaluate four novel SARS-CoV-2 neutralizing antibody assay kits' application in neutralizing antibodies of population. Questionnaires from the voluntary participating researchers and selected the qualified questionnaires to analyse.
Hui Zhen, Ya Cheng, Qimeng Sun, Ying Zheng, Lili Tian, Chao Shen, Li Li, Jie Gong, Yonggang Chen, Hongping Ba   +9 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Function and structure of broadly neutralizing antibodies against SARS-CoV-2 Omicron variants isolated from prototype strain infected convalescents

Journal of Translational Medicine
Background The ongoing emergence of evolving SARS-CoV-2 variants poses great threaten to the efficacy of authorized monoclonal antibody-based passive immunization or treatments. Developing potent broadly neutralizing antibodies (bNabs) against SARS-CoV-2
Dan Li, Caiqin Hu, Junwei Su, Shuo Du, Ying Zhang, Wanqi Ni, Li Ren, Yanling Hao, Yi Feng, Changzhong Jin, Shuo Wang, Xinxian Dai, Zheng Wang, Biao Zhu, Junyu Xiao, Yiming Shao   +15 more
doaj   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Age distribution of DENV neutralizing antibodies in 2010.

, 2016
Samples were collected between March and June 2010, approximately 6 months prior to a large dengue epidemic largely caused by American/Asian genotype DENV-2. Panel A: Age distribution of serotype-specific DENV neutralizing antibodies.
Angelica Espinoza (2137915), Tadeusz J. Kochel (137222), Kanya C. Long (2137906), Wilma Casanova (2137918), Stalin Vilcarromero (372094), Eric S. Halsey (129244), Brett M. Forshey (249475), Sandra Olkowski (2137909), Steven T. Stoddard (167457), Thomas W. Scott (102260), Robert C. Reiner (2137912), Amy C. Morrison (108730), Helen J. Wearing (245189)   +12 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques

, 2017
Neutralizing antibodies prevent Zika infection in nonhuman primates.
Mauricio A. Martins, Alexander Strubel, Grubaugh, Nathan D., Pedreño-Lopez, Núria, Kallas, Esper G, Kallas, Esper Georges, Watkins, David I., Thomas H. Vanderford, David I. Watkins, Bonaldo, Myrna C., Whitehead, Stephen S, Gutman, Martin J., Bonaldo, Myrna C, Sherrie Jean, Stephen S. Whitehead, Bryan Briney, Vanderford, Thomas H., Chahroudi, Ann, Grubaugh, Nathan D, Strubel, Alexander, Esper G. Kallas, Sok, Devin, Thomas F. Rogers, Burton, Dennis R., Cassia G. T. Silveira, Magnani, Diogo M, Bailey, Varian K, Lucas Gonzalez-Nieto, Rogers, Thomas F, Silveira, Cassia G T, Nathan Beutler, Martins, Mauricio A, Ronald C. Desrosiers, Diogo M. Magnani, Bailey, Varian K., Aline Domingues, Gonzalez Nieto, Lucas, Ricciardi, Michael J., Devin Sok, Jean, Sherrie, Magnani, Diogo M., Watkins, David I, Burton, Dennis R, Ann Chahroudi, Strobert, Elizabeth A., Rogers, Thomas F., Vanderford, Thomas H, Núria Pedreño-Lopez, Erica E. Okwuazi, Lee, David E, Varian K. Bailey, Maxwell, Helen S., Michael J. Ricciardi, Dennis R. Burton, Gonzalez-Nieto, Lucas, Myrna C. Bonaldo, Martin J. Gutman, Elizabeth A. Strobert, Desrosiers, Ronald C., Helen S. Maxwell, Briney, Bryan, Desrosiers, Ronald C, Maxwell, Helen S, Domingues, Aline, Silvestri, Guido, Okwuazi, Erica E., Whitehead, Stephen S., Lee, David E., Martins, Mauricio A., Strobert, Elizabeth A, Le, Khoa, David E. Lee, Guido Silvestri, Beutler, Nathan, Silveira, Cassia G. T., Gutman, Martin J, Ricciardi, Michael J, Khoa Le, Nathan D. Grubaugh, Okwuazi, Erica E   +79 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Distribution pattern of dengue serotype-specific neutralizing antibodies by PRNT.

, 2018
Distribution pattern of dengue serotype-specific neutralizing antibodies by PRNT.
Shubham Shrivastava (408570), Akhilesh C. Mishra (137429), Pritam H. Mahadik (5598050), Swapnil A. Gadhave (5598047), Mandar Bhutkar (5598053), Vidya A. Arankalle (188036), Varsha M. Vaidya (5598056)   +6 more
core   +1 more source