Results 71 to 80 of about 1,017,928 (387)

Nutraceutical Extract from Dulse (Palmaria palmata L.) Inhibits Primary Human Neutrophil Activation [PDF]

, 2019
Palmaria palmata L. (Palmariaceae), commonly known as "dulse", is a red alga that grows on the northern coasts of the Atlantic and Pacific oceans, and is widely used as source of fiber and protein.
Bermúdez Pulgarín, Beatriz, Claro Cala, Carmen María, Martín Rubio, María Esther, Millán Rodríguez, Francisco, Millán-Linares, María del Carmen, Montserrat de la Paz, Sergio, Pedroche, Justo, Rodríguez Martín, Noelia María, Toscano Sánchez, Mª del Rocío   +8 more
core   +1 more source

High-Content Screening Identifies Vanilloids as a Novel Class of Inhibitors of NET Formation

Frontiers in Immunology, 2019
Neutrophils migrate to sites of infection where they phagocytose, degranulate, and/or, in the presence of appropriate stimuli, release decondensed chromatin strands (called neutrophil extracellular traps, NETs) for trapping and possibly killing ...
Elvira Sondo, Roberta Bertelli, Emanuela Pesce, Gian Marco Ghiggeri, Nicoletta Pedemonte   +4 more
doaj   +1 more source

Identification of the Transgene Integration Site and Host Genome Changes in MRP8-Cre/ires-EGFP Transgenic Mice by Targeted Locus Amplification

Frontiers in Immunology, 2022
The MRP8-Cre-ires/EGFP transgenic mouse (Mrp8creTg, on C57BL/6J genetic background) is popular in immunological and hematological research for specifically expressing Cre recombinase and an EGFP reporter in neutrophils.
Guan Wang, Guan Wang, Cunling Zhang, Hiroto Kambara, Hiroto Kambara, Cheryl Dambrot, Xuemei Xie, Xuemei Xie, Li Zhao, Li Zhao, Rong Xu, Rong Xu, Andrea Oneglia, Fei Liu, Hongbo R. Luo, Hongbo R. Luo   +15 more
doaj   +1 more source

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice

Science, 2018
Waking up in a trap Cancer patients who have undergone successful treatment can experience relapse of their disease years or even decades later. This is because cancer cells that have disseminated beyond the primary tumor site enter a state of dormancy ...
Jean Albrengues, M. Shields, David Ng, Chun Gwon Park, A. Ambrico, M. Poindexter, P. Upadhyay, D. Uyeminami, Arnaud Pommier, Victoria Küttner, Emilis Bružas, L. Maiorino, Carmelita Bautista, Ellese M. Carmona, P. Gimotty, D. Fearon, K. Chang, S. Lyons, K. Pinkerton, L. Trotman, Michael S. Goldberg, J. Yeh, M. Egeblad   +22 more
semanticscholar   +1 more source

Reliable genetic diagnosis of NCF1 (p47phox)-deficient chronic granulomatous disease using high-throughput sequencing

Frontiers in Immunology
IntroductionChronic granulomatous disease is caused by mutations in any of the 6 components of the phagocytic NADPH oxidase complex including gp91phox, p47phox, p22phox, p40phox, p67phox, or EROS.
Amy P. Hsu, Eric Karlins, Justin Lack, Justin Lack, T. Joseph Pepper, Karen Lau, Kimberly R. Marshall-Batty, Debra Long Priel, Joie Davis, Danielle L. Fink, Christa S. Zerbe, John I. Gallin, Harry L. Malech, Steven M. Holland, Douglas B. Kuhns   +14 more
doaj   +1 more source

Neutrophil chemotaxis score and chemotaxis-related genes have the potential for clinical application to prognosticate the survival of patients with tumours

BMC Cancer
As frontline cells, the precise recruitment of neutrophils is crucial for resolving inflammation and maintaining the homeostasis of the organism. Increasing evidence suggests the pivotal role of neutrophil chemotaxis in cancer progression and metastasis.
Yunxi Yang, Jun Yang, Linbin Li, Yiming Shao, Lu Liu, Bingwei Sun   +5 more
doaj   +1 more source

Neutrophil-induced ferroptosis promotes tumor necrosis in glioblastoma progression

Nature Communications, 2020
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure.
Patricia P. Yee, Yiju Wei, Soo-Yeon Kim, Tong Lu, Stephen Y. Chih, Cynthia Lawson, Miaolu Tang, Zhijun Liu, Benjamin Anderson, K. Thamburaj, Megan M. Young, D. Aregawi, M. Glantz, B. Zacharia, C. Specht, Hong-Gang Wang, Wei Li   +16 more
semanticscholar   +1 more source

The Neutrophil [PDF]

, 2007
The neutrophil provides a crucial defence against fungal infections. This numerous phagocyte is recruited rapidly to sites of infection, where it detects pathogens through a range of pathogen-recognition receptors. Phagocytosis and the generation of a range of microbicidal molecules neutralises the pathogen, following which neutrophil death by ...
Dockrell, David H., McGrath, Emmet E., Whyte, Moria K.B., Sabroe, Ian   +3 more
openaire   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Investigation of Allogeneic Neutrophil Transfusion in Improving Survival Rates of Severe Infection Mice

Cell Transplantation
The management of granulocytopenia-associated infections is challenging, and a high mortality rate is associated with traditional supportive therapies.
Linbin Li, Yunxi Yang, Zaiwen Guo, Xi Gao, Lu Liu, Jiamin Huang, Bingwei Sun   +6 more
doaj   +1 more source