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Plant Phenolics Inhibit Neutrophil Elastase
Planta Medica, 2006Human neutrophil elastase (HNE) is a serine protease, which is present in its active form in inflamed tissue as well as in psoriatic lesions. In extension of our research on natural compounds as inhibitors of HNE or of its release, several phenolics of different size were tested. The ellagitannins agrimoniin and pedunculagin were the most potent direct
Hrenn, Andrea +5 more
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Blood, 2005
Comment on Massullo et al, page [3397][1] The frustration of animal models aside, a simple cell culture model offers insight into how mutant neutrophil elastase causes hereditary neutropenia.
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Comment on Massullo et al, page [3397][1] The frustration of animal models aside, a simple cell culture model offers insight into how mutant neutrophil elastase causes hereditary neutropenia.
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Neutrophil elastase: Nonsense lost in translation
Cell Stem Cell, 2021In this issue of Cell Stem Cell, Daniel Bauer and colleagues investigate the pathogenesis of ELANE-associated severe congenital neutropenia (SCN) and describe two potentially universal gene correction strategies for autosomal dominant disorders (Rao et al., 2021). One exploits nonsense-mediated decay to prevent translation of the mutant allele.
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Targeting neutrophil elastase in cystic fibrosis
Expert Opinion on Therapeutic Targets, 2008Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection.This review examines the ...
Emer, Kelly +2 more
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Intensive Care Medicine, 1994
To test the hypothesis whether PMN-Elastase in bronchoalveolar lavage fluid (BALF) could reflect neutrophil activity in the lower respiratory tract.Prospectively, morphologic findings of acute and chronic inflammation in the transbronchial lung biopsy specimens were compared with the numbers of neutrophils in the BALF and the concentration of PMN ...
A, Lengas +5 more
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To test the hypothesis whether PMN-Elastase in bronchoalveolar lavage fluid (BALF) could reflect neutrophil activity in the lower respiratory tract.Prospectively, morphologic findings of acute and chronic inflammation in the transbronchial lung biopsy specimens were compared with the numbers of neutrophils in the BALF and the concentration of PMN ...
A, Lengas +5 more
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Activated Neutrophils Impair Gastric Cytoprotection: Role of Neutrophil Elastase
Digestive Diseases and Sciences, 2000Neutrophil elastase decreases production of PGI2 by cultured endothelial cells. Thus, neutrophil elastase may play an important role in gastric mucosal injury by decreasing the tissue level of PGI2, an important gastric cytoprotective substance. We examined whether activated neutrophils inhibit gastric PGI2 production in rats subjected to water ...
N, Harada, K, Okajima, W, Liu, M, Uchiba
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Biological Chemistry Hoppe-Seyler, 1992
Sheep are often used to study tissue damage following shock after traumatic injury and in the course of other diseases. The processes involved are thought to be caused at least in part by elastase released from polymorphonuclear leukocytes (PMNs). Since little is known about elastase and its role as a mediator of tissue damage in sheep, we studied the ...
W G, Junger +4 more
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Sheep are often used to study tissue damage following shock after traumatic injury and in the course of other diseases. The processes involved are thought to be caused at least in part by elastase released from polymorphonuclear leukocytes (PMNs). Since little is known about elastase and its role as a mediator of tissue damage in sheep, we studied the ...
W G, Junger +4 more
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Chapter 24. Neutrophil Elastase
1985Publisher Summary This chapter discusses the biochemical properties, roles in normal physiology, and possible involvement in pathological states of the elastase from human neutrophils. Human leukocyte elastase (HLE) is a serine proteinase,as evidenced by its inhibition by diisopropyl fluorophosphate, phenylmethyl sulfonyl fluoride, and alpha-1 ...
R.L. Stein, D.A. Trainor, R.A. Wildonger
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Neutrophil elastase and neutropenia
Blood, 2004HEMATOPOIESIS Neutrophil elastase ([NE] also called elastase-2 [ELA-2]) is a powerful serine protease stored in the primary granule of neutrophils.[1][1] This enzyme is synthesized primarily at the promyelocyte stage of neutrophil development in the bone marrow.
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Inhibitors of human neutrophil elastase
Expert Opinion on Therapeutic Patents, 1997Human neutrophil elastase (HNE) is a serine protease that is responsible for a number of diverse pathological conditions. Synthetic inhibitors which can regulate the in vivo activity of HNE will therefore have broad therapeutic applications. Over the past 15 years a diverse set of strategies have been pursued for the development of HNE inhibitors, the ...
Philip D Edwards, Chris A Veale
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