Results 41 to 50 of about 845,167 (291)

Neutrophil Extracellular Traps in Periodontitis [PDF]

, 2020
Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released
O'Valle Ravassa, Francisco Javier, Benavides-Reyes, Cristina, Abadía Molina, Francisco, Abadía-Molina, Francisco, Francisco Abadía-Molina, Francisco Mesa, Benavides Reyes, Cristina, O'Valle, Francisco, Mesa Aguado, Francisco Luis, Cristina Benavides-Reyes, Magán-Fernández, Antonio, Antonio Magán-Fernández, Francisco O’Valle, Magán Fernández, Antonio, Rasheed Al-Bakri, Sarmad Muayad, Mesa, Francisco, Sarmad Muayad Rasheed Al-Bakri   +16 more
core   +1 more source

Simplified Human Neutrophil Extracellular Traps (NETs) Isolation and Handling [PDF]

Journal of Visualized Experiments, 2015
Neutrophil Extracellular Traps (NETs) have been recently identified as part of the neutrophil's antimicrobial armamentarium. Apart from their role in fighting infections, recent research has demonstrated that they may be involved in many other disease processes, including cancer progression.
Sara, Najmeh, Jonathan, Cools-Lartigue, Betty, Giannias, Jonathan, Spicer, Lorenzo E, Ferri   +4 more
openaire   +2 more sources

Characterization, Quantification, and Visualization of Neutrophil Extracellular Traps

, 2022
Following the discovery of neutrophil extracellular traps (NETs) in 2004 by Brinkmann and colleagues, there has been extensive research into the role of NETs in a number of inflammatory diseases, including periodontitis.
Hirschfeld, Josefine, White, Phillipa, Wright, Helen J., Chapple, Iain; id_orcid, Chicca, Ilaria, Chicca, Ilaria J., Ling, Martin, Ling, Martin R., Milward, Michael, Milward, Mike R., Chapple, Iain L.C., Moonen, Carolyn G.J., White, Phillipa C., Cooper, Paul R., Wright, Helen   +14 more
core   +2 more sources

M1 Macrophages Drive Cxcr2+ Netosis Via Cxcl8/Cxcr2 In Pulpitis

International Dental Journal
Aim or purpose: To elucidate how M1 macrophages exacerbate pulpitis by driving CXCR2+ neutrophil extracellular traps (NETs) formation via the CXCL8/CXCR2 signaling axis. Materials and methods: We performed single-cell RNA sequencing (scRNA-seq) on normal
Ruilin Zhang
doaj   +1 more source

Imaging of Neutrophils and Neutrophil Extracellular Traps (NETs) with Intravital (In Vivo) Microscopy

, 2019
As we have learned during recent years, neutrophils are not just simple foot soldiers of the innate immune system with a restricted set of pro-inflammatory functions, and instead, they perform sophisticated functions (some of them only recently discovered) both in innate and adaptive immune responses.
Cichoń, Iwona, Santocki, Michał, Ortmann, Weronika, Kołaczkowska, Elżbieta   +3 more
openaire   +3 more sources

ETosis: A Microbicidal Mechanism beyond Cell Death

Journal of Parasitology Research, 2012
Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins.
Anderson B. Guimarães-Costa, Michelle T. C. Nascimento, Amanda B. Wardini, Lucia H. Pinto-da-Silva, Elvira M. Saraiva   +4 more
doaj   +1 more source

In vitro Demonstration and Quantification of Neutrophil Extracellular Trap Formation

Bio-Protocol, 2017
In the recent decade, neutrophil extracellular traps (NETs) have been identified and confirmed as a new anti-microbial weapon of neutrophils. In this protocol, we describe easy methods to demonstrate NET formation by immunofluorescence staining of ...
Dongsheng Jiang, Mona Saffarzadeh, Karin Scharffetter-Kochanek   +2 more
doaj   +1 more source

Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones [PDF]

, 2013
Neutrophil extracellular traps are networks of DNA and associated proteins produced by nucleosome release from activated neutrophils in response to infection stimuli and have recently been identified as key mediators between innate immunity, inflammation,
Szabó, László, Szab , L., Hoell, Armin, Kolev, Krasimir, Sótonyi, Péter, Longstaff, C., Longstaff C, Krumrey, M., Komorowicz, E., Longstaff, Colin, Varjú, Imre, Kolev, K., Varga, Z., Kolev, Kraszimir Nikolaev, Komorowicz, Erzsébet, Krumrey, Michael, Hoell A, S tonyi, P., Krumrey M, Varju, I., Hoell, A., Bóta, Attila, Varga, Zoltán, B ta, A.   +23 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Resistance of hypervirulent Klebsiella pneumoniae to both intracellular and extracellular killing of neutrophils. [PDF]

PLoS ONE, 2017
Hypervirulent Klebsiella pneumoniae (HvKP) is hypermucoviscous organism, carrying genes of rmpA and aerobactin, causing serious community-acquired infection and metastatically spread in young healthy hosts.
Lifeng Wang, Dingxia Shen, Hua Wu, Yanning Ma   +3 more
doaj   +1 more source