Results 51 to 60 of about 845,167 (291)

The Balance of Neutrophil Extracellular Trap Formation and Nuclease Degradation: an Unknown Role of Bacterial Coinfections in COVID-19 Patients?

mBio, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to public health crises worldwide. An understanding of the pathogenesis and the development of treatment strategies is of high interest.
Nicole de Buhr, Maren von Köckritz-Blickwede   +1 more
doaj   +1 more source

Neutrophil extracellular traps (NETs) in coronary artery disease: Prognostic value and roles in atherothrombosis

, 2022
Despite advances in the treatment of coronary artery disease, our understanding of atherothrombosis is incomplete. Increasing evidence highlights immune cells as key players in this complex process.
Langseth, Miriam Sjåstad
core   +1 more source

Neutrophil Extracellular Trap (NET) Impact on Deep Vein Thrombosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Deep vein thrombosis (DVT) is a major health problem that requires improved prophylaxis and treatment. Inflammatory conditions such as infection, cancer, and autoimmune diseases are risk factors for DVT. We and others have recently shown that extracellular DNA fibers produced in inflammation and known as neutrophil extracellular traps (NETs) contribute
Tobias A, Fuchs, Alexander, Brill, Denisa D, Wagner   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A novel approach to identifying and quantifying neutrophil extracellular trap formation in septic dogs using immunofluorescence microscopy

BMC Veterinary Research, 2018
Background Canine neutrophils release neutrophil extracellular traps (NETs) in response to lipopolysaccharide but NETs from clinical septic dogs had not been identified.
Ronald H. L. Li, Lynelle R. Johnson, Casey Kohen, Fern Tablin   +3 more
doaj   +1 more source

Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice

Frontiers in Oncology, 2021
Characterized as a complex of extracellular DNA fibers and granule proteins, neutrophil extracellular traps (NETs) are generated specifically by neutrophils which play a critical role in host defense and immune regulation.
Yuxin Chen, Yuxin Chen, Lulu Han, Lulu Han, Lulu Han, Xiaoyan Qiu, Xiaoyan Qiu, Gang Wang, Gang Wang, Gang Wang, Junnian Zheng, Junnian Zheng   +11 more
doaj   +1 more source

Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis [PDF]

Critical Care, 2019
Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown.Infant (2 weeks old) and adult (6 weeks old) mice were submitted to sepsis by intraperitoneal (i.p.) injection of bacteria suspension or lipopolysaccharide (LPS).
David F. Colón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho, Ana P. Carlotti, Fabio Carmona, Jose C. Alves-Filho, Foo Y. Liew, Fernando Q. Cunha   +17 more
openaire   +4 more sources

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Macrophage polarization modulates neutrophil extracellular trap dynamics and reciprocal macrophage responses

Frontiers in Immunology
The interplay between neutrophils and macrophages is central to inflammatory regulation, yet how macrophage polarization governs the homeostasis of neutrophil extracellular traps (NETs) remains poorly understood.
Laura Blum, Laura Blum, Laura Blum, Kira Jäger, Makenzie Jones, Julia Elrod, Julia Elrod, Julia Elrod, Michael Boettcher, Michael Boettcher, Michael Boettcher, Jasmin Knopf, Jasmin Knopf, Jasmin Knopf   +13 more
doaj   +1 more source

Neutrophil extracellular traps in host defense

, 2020
Neutrophils are produced in the bone marrow and then patrol blood vessels from which they can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill invading microbes via a suite of defense mechanisms.
Burgener, Sabrina Sofia, Schroder, Kate
core   +1 more source