Results 151 to 160 of about 1,037,717 (382)

An overview of the role of neutrophils in innate immunity, inflammation and host-biomaterial integration

Regenerative Biomaterials, 2017
Despite considerable recent progress in defining neutrophil functions and behaviors in tissue repair, much remains to be determined with regards to its overall role in the tissue integration of biomaterials.
Gretchen S. Selders, A. Fetz, M. Radic, G. Bowlin   +3 more
semanticscholar   +1 more source

The Neutrophil Life Cycle

Trends in Immunology, 2019
Neutrophils are recognized as an essential part of the innate immune response, but an active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in the bone marrow through progenitor intermediaries before entering the blood, in a process that gauges the extramedullary pool size.
Edwin R. Chilvers, Leo Koenderman, Andrés Hidalgo, Andrés Hidalgo, Charlotte Summers   +4 more
openaire   +6 more sources

Time trends and predictors of gout remission over six years

Arthritis Care &Research, Accepted Article.
Objectives This study aims to describe the trends in remission rates over six years of follow‐up among people with gout taking urate‐lowering therapy (ULT), and to identify variables that predict remission. Methods A post hoc analysis was conducted using data from the Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES ...
Adwoa Dansoa Tabi‐Amponsah, Sarah Stewart, Greg Gamble, Lisa K Stamp, William J Taylor, Nicola Dalbeth   +5 more
wiley   +1 more source

CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses [PDF]

, 2017
CXCR2 is an essential regulator of neutrophil recruitment to inflamed and damaged sites and plays prominent roles in inflammatory pathologies and cancer. It has therefore been highlighted as an important therapeutic target.
A Mantovani, A Rot, A Rot, A Zlotnik, A Zlotnik, AA Filardy, AE Cardona, AEI Proudfoot, C Schinke, D Marvel, DI Gabrilovich, F Bachelerie, F Balkwill, F Porcheray, F Sallusto, FR Balkwill, G Cacalano, H Saiwai, HM Baldwin, J Dalli, J Schindelin, J Yang, J-I Youn, J-I Youn, K Kishida, KM Hertzer, L Liu, M-C Lo, MK Ho, O Soehnlein, P Ranganathan, P Scapini, RA Navarro-Xavier, RM Devalaraja, S Milatovic, T Jamieson, T Jamieson, T Kakinuma, TJ Schall   +38 more
core   +1 more source

A Morphological Sex Difference in the Polymorphonuclear Neutrophil Leucocytes [PDF]

, 1954
W. M. Davidson, D. R. Smith
openalex   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

Nature Communications, 2018
Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions.
Christopher M. Rice, L. Davies, J. Subleski, N. Maio, Marieli Gonzalez-Cotto, C. Andrews, Nimit L. Patel, Erika M. Palmieri, J. Weiss, Jung-Min Lee, C. Annunziata, T. Rouault, S. Durum, D. McVicar   +13 more
semanticscholar   +1 more source

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection [PDF]

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
A Boëdec, A Matsushima, A Reichenberg, AC Brown, AC Hayday, AC Hayday, Amanda C. Brown, B Altincicek, B Moser, Bernhard Moser, C Agrati, C Belmant, C De Santo, C Münz, CC Szeto, Chan-Yu Lin, CM Bunke, Colin Hill, Cormac G. M. Gahan, CT Morita, CT Spencer, CT Weaver, D Vermijlen, David W. Johnson, DI Godfrey, DJ Pennington, DK Kim, E Oldfield, E. John Wherry, F Annunziato, F Dieli, F Sallusto, G Sarikonda, Gareth W. Roberts, GW Roberts, H Jomaa, H Jomaa, H Li, H Wang, H Wei, I Müller, J Feurle, J Mookerjee-Basu, James A. Chess, JF Bukowski, JJ O'Shea, John D. Williams, JS Savill, K Pietschmann, KJ Puan, KK Kumarasamy, KM Murphy, L Troidle, M Begley, M Begley, M Blunden, M Bonneville, M Brandes, M Eberl, M Eberl, M Eberl, M Eberl, M Eberl, M Fahim, M Kistowska, M Krishnan, M Pelletier, M Rohmer, MA Missinou, Mark A. Toleman, Martin S. Davey, Matthias Eberl, MC Devilder, MC Devilder, MI Hirsh, MJ Llewelyn, N Nathan, N Topley, Nicholas Topley, O Devuyst, P Choi, P Constant, PS Evans, R Medzhitov, RE Rojas, RM McLoughlin, S Amslinger, S Mujais, Simon J. Davies, Sinéad Heuston, SJ Davies, SM Hurst, SR Gill, T Ganz, Tanya Parish, TR Walsh, TW Rice, W Holtmeier, Y Kato, Y Neu, Y Tanaka, Y Zhang   +101 more
core   +5 more sources

The Individuality of Nuclear Chromatin with Particular Reference to Polymorphonuclear Neutrophil Leukocytes [PDF]

, 1958
Donald K. Briggs
openalex   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source