Results 41 to 50 of about 530,516 (247)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable

Journal of Translational Medicine
Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to ...
Claire A. Naveh, Kiran Roberts, Przemysław Zakrzewski, Christopher M. Rice, Fernando M. Ponce-Garcia, Kathryn Fleming, Megan Thompson, Nawamin Panyapiean, Huan Jiang, Stephanie Diezmann, Pedro L. Moura, Ashley M. Toye, Borko Amulic   +12 more
doaj   +1 more source

Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype

Frontiers in Immunology
Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (SLE); however, the exact role of normal-density neutrophils in SLE remains unknown.
Neelakshi R. Jog, Catriona A. Wagner, Teresa Aberle, Eliza F. Chakravarty, Cristina Arriens, Joel M. Guthridge, Judith A. James, Judith A. James   +7 more
doaj   +1 more source

Neutrophils in Gliomas

Frontiers in Immunology, 2017
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation ...
Matteo Massara, Matteo Massara, Pasquale Persico, Ornella Bonavita, Ornella Bonavita, Valeria Mollica Poeta, Valeria Mollica Poeta, Massimo Locati, Massimo Locati, Matteo Simonelli, Matteo Simonelli, Raffaella Bonecchi, Raffaella Bonecchi   +12 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Neutrophils in Psoriasis

Frontiers in Immunology, 2019
Neutrophils are the most abundant innate immune cells. The pathogenic roles of neutrophils are related to chronic inflammation and autoimmune diseases. Psoriasis is a chronic systemic inflammatory disease affecting ~2–3% of the world population.
Chih-Chao Chiang, Chih-Chao Chiang, Chih-Chao Chiang, Wei-Jen Cheng, Wei-Jen Cheng, Wei-Jen Cheng, Michal Korinek, Michal Korinek, Michal Korinek, Cheng-Yu Lin, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang, Tsong-Long Hwang   +15 more
doaj   +1 more source

A controversial role of neutrophils in tuberculosis infection pathogenesis

Инфекция и иммунитет, 2021
Tuberculosis (TB) continues to be an important and unresolved medical problem. About a quarter of mankind is infected with Mycobacterium tuberculosis, and about 5–10% of these people eventually develop TB.
I. A. Linge, A. S. Apt
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Pro-inflammatory role of neutrophils populations in trauma patients: monitoring neutrophil populations

Frontiers in Immunology
BackgroundTrauma is a leading global cause of mortality, and systemic inflammatory response syndrome (SIRS) remains a significant complication, contributing to adverse outcomes.
Marcela Vlková, Marcela Vlková, Julie Štíchová, Julie Štíchová, Karolína Surá, Karolína Surá, Karolína Dvořáková, Karolína Dvořáková, Vojtěch Kunčický, Vojtěch Kunčický, Ioanna Papatheodorou, Ioanna Papatheodorou, Gabriela Blažková, Zuzana Tomášiková, Zuzana Tomášiková, Kamila Bendíčková, Kamila Bendíčková, Ludmila Dohnálková, Alexandra Mýtniková, Alexandra Mýtniková, Alexandra Mýtniková, Jan Žák, Jan Kovařík, Milan Krtička, Tomáš Tomáš, Vladimír Šrámek, Martin Helán, Martin Helán, Anna Kocurková, Anna Kocurková, Anna Kocurková, Jan Frič, Jan Frič, Jan Frič, Marcela Hortová-Kohoutková, Marcela Hortová-Kohoutková   +35 more
doaj   +1 more source

Neutrophil: A New Player in Metastatic Cancers

Frontiers in Immunology, 2020
The interaction between cancer cells and immune cells is important for the cancer development. However, much attention has been given to T cells and macrophages. Being the most abundant leukocytes in the blood, the functions of neutrophils in cancer have
Mengyue Wu, Mutian Ma, Zhenya Tan, Hong Zheng, Xia Liu   +4 more
doaj   +1 more source