Chemical and Toxicological Analysis of Antiretroviral Drugs
Разработка и регистрация лекарственных средств, 2019 Introduction. Human Immunodeficiency Virus (HIV) is one of the main socially significant infection all over the world. HIV-positive patients take medical care, including antiretroviral drugs (ARVs) pharmacotherapy.
T. N. Komarov +7 more
doaj +1 more source
Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery
Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju +3 more
wiley +1 more source
The role of CYP3A in nevirapine induced hepatotoxicity
, 2003 Nevirapine is a potent non-nucleoside reverse transcriptase inhibitor with favourable pharmacokinetics that are characterised by rapid absorption and distribution with a long elimination half-life.
Barr, Shera
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Exposure of Allium cepa root cells to zidovudine or nevirapine induces cytogenotoxic changes.
PLoS ONE, 2014 Antiretroviral drugs have proved useful in the clinical management of HIV-infected persons, though there are concerns about the effects of exposure to these DNA-reactive drugs.
Chika K Onwuamah +5 more
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HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients
, 2006 Background: Hypersensitivity reaction to nevirapine, which in some cases can be fatal, shows a higher prevalence in Sardinia in comparison with other Italian regions.
Piano, P +10 more
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Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions. [PDF]
, 2014 OBJECTIVES: Nevirapine is widely used for the treatment of HIV-1 infection; however, its chronic use has been associated with severe liver and skin toxicity.
Rodrigues, P +32 more
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Viral load and nevirapine concentration quartiles in hair and plasma.
, 2022 Viral load and nevirapine concentration quartiles in hair and plasma.
Bindiya Meggi (709168) +11 more
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Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity
, 2014 Item does not contain fulltextOBJECTIVES: The reduction in mother-to-child transmission of HIV-1 by single-dose nevirapine given at birth onset is achieved at the expense of de novo HIV-1 resistance mutations.
Burger, D +29 more
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SPECTROPHOTOMETRIC DETERMINATION OF NEVIRAPINE USING TETRATHIOCYANATOCOBALT(II) ION AS A REAGENT
Eclética Química, 2018 A simple and rapid spectrophotometric method for the determination of nevirapine is described. The method is based on the reaction of nevirapine with tetrathiocyanatocobalt(II) ion in buffer of pH 4 to form the corresponding complex. Beer’s law is obeyed
T. V. Badiadka, Badiadka Narayana
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This Is Not a Myeloproliferative Neoplasm…
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
Stephanie Juané Kennedy
wiley +1 more source