Results 51 to 60 of about 19,421 (203)

Emerging Trends in Organic Photoreactions Utilizing Disulfides

European Journal of Organic Chemistry, Volume 29, Issue 21, 4 June 2026.
Disulfides are versatile, nontoxic alternatives to metal photocatalysts. This review explores their role as photoactivated thiyl‐radical precursors and bifunctional catalysts (HAT/electron shuttling) in diverse transformations. Strategies for electronic tuning and development into recyclable heterogeneous materials are highlighted for sustainable ...
Sunil Kumar, Bolormaa Bayarkhuu, Hong Y. Cho, Jeehye Byun   +3 more
wiley   +1 more source

Nevirapine- and efavirenz-associated hepatotoxicity under programmatic conditions in Kenya and Mozambique.

, 2012
To describe the frequency, risk factors, and clinical signs and symptoms associated with hepatotoxicity (HT) in patients on nevirapine- or efavirenz-based antiretroviral therapy (ART), we conducted a retrospective cohort analysis of patients attending ...
Ford, N P, Zachariah, R, Manzi, M, Biot, M, Rasschaert, F, Chu, K M, Zuniga, I   +6 more
core   +1 more source

Severe Cutaneous Adverse Reactions Associated With Newer‐Generation Antiseizure Medications: A Real‐World Pharmacovigilance Study Based on FAERS and JADER

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
A cross‐database analysis of FAERS and JADER confirmed lamotrigine and zonisamide as the dominant SJS/TEN/DRESS risk drivers across both systems. After polytherapy adjustment, eslicarbazepine (DRESS, ROR 10.41) and levetiracetam emerged as reproducible novel signals warranting clinical attention. SJS/TEN onset concentrated within 4 weeks, whereas DRESS
Longfei You, Dong Zhang, Zhihua Cheng, Yinbao Qi, Ruobing Qian   +4 more
wiley   +1 more source

Acceptability of a Dolutegravir Oral Dispersible Film in Term Neonates Born to Mothers Living With HIV

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Dolutegravir (DTG) is a key antiretroviral (ARV) drug for children living with HIV, but no specific formulation is available for neonates (<28 days old). One of the DTG formulations evaluated in the PETITE‐DTG trial was a novel 5 mg oral DTG dispersible film (DTG‐Film).
Lario Viljoen, Charlene Purdy, Verah Luke, Samantha du Toit, Marisa Groenewald, Lindee Ganger, Anneke C. Hesseling, Anthony J. Garcia‐Prats, Tim R. Cressey, Adrie Bekker   +9 more
wiley   +1 more source

Nevirapine-associated early hepatotoxicity: incidence, risk factors, and associated mortality in a primary care ART programme in South Africa.

, 2010
BACKGROUND: The majority of antiretroviral treatment programmes in sub-Saharan Africa are scaling up antiretroviral treatment using a fixed dose first-line antiretroviral regimen containing stavudine, lamivudine, and nevirapine.
Gilles Van Cutsem, Chu Kathryn M., Van Cutsem Gilles, Asselman Valerie, Goemaere Eric, Asselman, Valerie, Van Cutsem, Gilles, Valerie Asselman, Ford Nathan, Boulle Andrew M., Ford, Nathan, Andrew M Boulle, Goemaere, Eric, Nathan Ford, Chu, Kathryn M, Boulle, Andrew M, Kathryn M Chu, Eric Goemaere   +17 more
core   +1 more source

Optimizing Identification and Care of Pregnant/Breastfeeding Women Living With HIV in Resource‐Limited Settings

Journal of the International AIDS Society, Volume 29, Issue S1, June 2026.
ABSTRACT Introduction Since the mid‐1990s, there have been major advances in diagnosing and providing antiretroviral therapy (ART) for pregnant women living with HIV (WLWH) in both resource‐rich and resource‐limited settings. Initial progress was based on the 1994 landmark perinatal trial, which showed 67% reduction in vertical transmission among ...
Mary Glenn Fowler, Victoria B. Chou, Philippa Musoke   +2 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients [PDF]

, 2013
Dr. Fred Stephen Sarfo, The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV ...
SARFO, FRED,STEPHEN
core  

The rate of viral rebound after attainment of an HIV load < 50 copies/mL according to specific antiretroviral drugs in use: Results from a multicenter cohort study

, 2005
Background. Relatively few data are available on the association between the use of specific antiretroviral drugs and the rate of viral rebound in those attaining a viral load (VL) 500 copies/ mL).
Smith, CJ, Smith, C J, Phillips, AN, Porter, K, Scullard, G, Hill, T, Fisher, M, Phillips, A N, Easterbrook, P, Johnson, MA, Gilson, R, Sabin, C A, Gazzard, B, United Kingdom HIV Cohort Study, Matthias, R, Sabin, CA, Johnson, M A   +16 more
core   +1 more source

Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children [PDF]

, 2012
CITATION: Violari, A. et al. 2012. Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children. New England Journal of Medicine, 366:2380-2389, doi:10.1056/NEJMoa1113249.The original publication is available at https://www.nejm.orgBACKGROUND:
Paed, F. C., Eshleman, Susan H., Purdue, Lynette, Mujuru, Hilda A., Kamthunzi, Portia, Palumbo, Paul, Petzold, Elizabeth, Lindsey, Jane C., Bobat, Raziya, Cotton, Mark F., Chi, Benjamin H., Millar, Linda, Barlow-Mosha, Linda, Moultrie, Harry, Khadse, Sandhya, Abrams, Elaine J., Hughes, Michael D., Mofenson, Lynne M., Violari, Avy, Schimana, Werner, Jean-Philippe, Patrick   +20 more
core   +1 more source