Results 31 to 40 of about 19,421 (203)

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Beilstein Journal of Organic Chemistry, 2013
2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.
Ashley R. Longstreet, Suzanne M. Opalka, Brian S. Campbell, B. Frank Gupton, D. Tyler McQuade   +4 more
doaj   +1 more source

The antiretroviral efficacy of highly active antiretroviral therapy and plasma nevirapine concentrations in HIV-TB co-infected Indian patients receiving rifampicin based antituberculosis treatment

AIDS Research and Therapy, 2011
Background Rifampicin reduces the plasma concentrations of nevirapine in human immunodeficiency virus (HIV) and tuberculosis (TB) co-infected patients, who are administered these drugs concomitantly.
Sinha Sanjeev, Dhooria Sahajal, Kumar Sanjiv, Shah Nipam, Velpandian T, Ravi AK, Kumar Narendra, Ahmad Hafeez, Bhargwa Akshat, Chug Karan, Bumma Naresh, Chandrashekhar Rahul, Ekka Meera, Sreenivas Vishnu, Sharma Surendra K, Samantaray JC, Mitsuyasu Ronald   +16 more
doaj   +1 more source

Green HPLC quantification method of lamivudine, zidovudine and nevirapine with identification of related substances in tablets

Green Chemistry Letters and Reviews, 2022
A green HPLC method for lamivudine (3TC), zidovudine (AZT) and nevirapine (NVP) determination in fixed-dose combination tablets was developed using ethanol as both one of the mobile phases and the solvent for sample preparation. This method was validated
Ludivine Vieira-Sellaï, Mercedes Quintana, Ousmane Diop, Olivier Mercier, Sebastien Tarrit, Nawal Raimi, Alassan Ba, Benoit Maunit, Marie-Josephe Galmier   +8 more
doaj   +1 more source

Me-Better Drug Design Based on Nevirapine and Mechanism of Molecular Interactions with Y188C Mutant HIV-1 Reverse Transcriptase

Molecules, 2022
In this paper, the Y188C mutant HIV-1 reverse transcriptase (Y188CM-RT) target protein was constructed by homology modeling, and new ligands based on nevirapine (NVP) skeleton were designed by means of fragment growth. The binding activity of new ligands
Yan Wang, Aidong Wang, Jianhua Wang, Xiaoran Wu, Yijie Sun, Yan Wu   +5 more
doaj   +1 more source

Non-adherence to the single dose nevirapine regimen for the prevention of mother-to-child transmission of HIV in Bindura town, Zimbabwe: a cross-sectional analytic study

BMC Public Health, 2010
Background The Prevention of Mother to Child Transmission of HIV (PMTCT) programme was introduced at Bindura Hospital in 2003. Seven additional satellite PMTCT clinics were set up in the district to increase service coverage but uptake of PMTCT ...
Shambira Gerald N, Tshuma Clemence D, Kuonza Lazarus R, Tshimanga Mufuta   +3 more
doaj   +1 more source

Formulation and Characterization of Extended-Release Nevirapine Solid Dispersions Running Title: Extended Release Nevirapine Solid Dispersions

, 2022
The bioavailability of a drug is usually determined by its aqueous solubility and lipid permeability. Nevirapine is an antiretroviral drug that belongs to the BCS II with poor solubility but high permeability.
Ochen Faithfulness, Ifeoma C. Ekenna, Abali S. Okorie   +2 more
core   +1 more source

Affecting factors to effectiveness of starting therapy in children with hiv infection

Журнал инфектологии, 2015
The purpose of the research – to characterize of the factors that influence the effectiveness of the starting highly activе antiretroviral therapy in children with HIV infection.Materials and methods.
V. B. Denisenko, E. N. Simovanyan
doaj   +1 more source

Microbicides development programme: engaging the community in the standard of care debate in a vaginal microbicide trial in Mwanza, Tanzania. [PDF]

, 2009
BACKGROUND: HIV prevention research in resource-limited countries is associated with a variety of ethical dilemmas. Key amongst these is the question of what constitutes an appropriate standard of health care (SoC) for participants in HIV prevention ...
Soteli, Selephina, Nikolau, Lawi, Kazimoto, J., Selephina Soteli, Shagi, Charles, Lees, S., Moffat, C., Soteli Selephina, Vallely Andrew, Hayes Richard J, Katherine Shapiro, Sheena McCormack, Hayes, Richard J, Masanja, J., Shapiro Katherine, Lees, Shelley, Kazimoto, Johari, Changalucha John, McCormack, S., Soteli, S., Lees Shelley, Nikolau, L., Vallely, Andrew, Hayes, R.J., Joseph Masanja, Lawi Nikolau, Charles Shagi, Kazimoto Johari, Masanja, Joseph, Changalucha, John, Shagi Charles, Shapiro, Katherine, Shagi, C., Johari Kazimoto, Masanja Joseph, McCormack, Sheena, Moffat Claire, John Changalucha, Shapiro, K., Shelley Lees, Vallely,A., Richard J Hayes, McCormack Sheena, Changalucha, J., Nikolau Lawi, Claire Moffat, Andrew Vallely, Moffat, Claire   +47 more
core   +1 more source

Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)
Background: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions.
Labitta Pachira Aquaira, Sri Awalia Febriana, Nurwestu Rusetiyanti   +2 more
doaj   +1 more source

HIV drug resistance and treatment success in the Republic of Congo: Implications for optimized treatment

HIV Medicine, EarlyView.
Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning, Arcy Marcelin Elenga Ike, Johanna Holterhoff, Amira Stockinger, Darrel Ornelle Elion Assiana, Claujens Chastel Mfoutou Mapanguy, Freisnel Hermeland Mouzinga, Carola Horn, Isabelle Suarez, Ferdinand Heyn, Diane Alexia Fila, Hubert Banguissa, Fabien Roch Niama, Donatien Moukassa, Eva Heger, Francine Ntoumi, Clara Lehmann   +16 more
wiley   +1 more source