Results 31 to 40 of about 39,721 (242)

Treatment of Young Children with HIV Infection: Using Evidence to Inform Policymakers [PDF]

, 2012
PMCID: PMC3404108This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Abrams, EJ, Cotton, M, Gibb, DM, Mulenga, V, Musoke, P, Penazzato, M, Prendergast, AJ   +6 more
core   +3 more sources

Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study

AIDS Research and Therapy, 2017
BackgroundMoringa oleifera Lam., an herb commonly consumed by HIV-infected people on antiretroviral therapy, inhibits cytochrome P450 3A4, 1A2 and 2D6 activity in vitro; and may alter the pharmacokinetics (PK) of antiretroviral drugs metabolized via the ...
Tsitsi G. Monera-Penduka, C. Maponga, A. Wolfe, L. Wiesner, G. Morse, C. Nhachi   +5 more
semanticscholar   +2 more sources

Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration [PDF]

, 2011
Article approval pendingWith expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in
Boulle, Andrew, Davies, Mary-Ann, Egger, Matthias, Eley, Brian, Giddy, Janet, Keiser, Olivia, Moultrie, Harry, Rabie, Helena, Technau, Karl, Van Cutsem, Gilles, Wood, Robin   +10 more
core   +2 more sources

Review The Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors

Viruses, 2014
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are widely used to treat HIV-1-infected individuals; indeed most first-line antiretroviral therapies typically include one NNRTI in combination with two nucleoside analogs.
Nicolas Sluis-Cremer
doaj   +1 more source

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

Journal of Antimicrobial Chemotherapy, 2017
Background: The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%–10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
D. Carr, Stephane Bourgeois, M. Chaponda, L. Takeshita, A. Morris, E. Castro, A. Alfirevic, Andrew R. Jones, D. Rigden, Sam Haldenby, S. Khoo, D. Lalloo, R. Heyderman, C. Dandara, Elizabeth Kampira, J. V. van Oosterhout, F. Ssali, P. Munderi, G. Novelli, P. Borgiani, M. Nelson, Arthur L. Holden, P. Deloukas, M. Pirmohamed   +23 more
semanticscholar   +1 more source

Dipyridodiazepinone derivatives; synthesis and anti HIV-1 activity

Beilstein Journal of Organic Chemistry, 2009
Ten dipyridodiazepinone derivatives were synthesized and evaluated for their anti HIV-1 reverse transcriptase activity against wild-type and mutant type enzymes, K103N and Y181C. Two of them were found to be promising inhibitors for HIV-1 RT.
Nisachon Khunnawutmanotham, Nitirat Chimnoi, Arunee Thitithanyanont, Patchreenart Saparpakorn, Kiattawee Choowongkomon, Pornpan Pungpo, Supa Hannongbua, Supanna Techasakul   +7 more
doaj   +1 more source

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Beilstein Journal of Organic Chemistry, 2013
2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients.
Ashley R. Longstreet, Suzanne M. Opalka, Brian S. Campbell, B. Frank Gupton, D. Tyler McQuade   +4 more
doaj   +1 more source

The antiretroviral efficacy of highly active antiretroviral therapy and plasma nevirapine concentrations in HIV-TB co-infected Indian patients receiving rifampicin based antituberculosis treatment

AIDS Research and Therapy, 2011
Background Rifampicin reduces the plasma concentrations of nevirapine in human immunodeficiency virus (HIV) and tuberculosis (TB) co-infected patients, who are administered these drugs concomitantly.
Sinha Sanjeev, Dhooria Sahajal, Kumar Sanjiv, Shah Nipam, Velpandian T, Ravi AK, Kumar Narendra, Ahmad Hafeez, Bhargwa Akshat, Chug Karan, Bumma Naresh, Chandrashekhar Rahul, Ekka Meera, Sreenivas Vishnu, Sharma Surendra K, Samantaray JC, Mitsuyasu Ronald   +16 more
doaj   +1 more source

Confirming model-predicted pharmacokinetic interactions between bedaquiline and lopinavir/ritonavir or nevirapine in patients with HIV and drug-resistant tuberculosis.

International Journal of Antimicrobial Agents, 2017
Bedaquiline and its metabolite M2 are metabolised by CYP3A4. The antiretrovirals ritonavir-boosted lopinavir (LPV/r) and nevirapine inhibit and induce CYP3A4, respectively.
M. J. Brill, E. Svensson, M. Pandie, G. Maartens, M. Karlsson   +4 more
semanticscholar   +1 more source

Optimization of diarylazines as anti-HIV agents with dramatically [PDF]

, 2013
Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity.
Anderson, Karen S., Bollini, Mariela, Cisneros, José A., Jorgensen, William L., Spasov, Krasimir A.   +4 more
core   +1 more source