Results 41 to 50 of about 20,764 (191)

4‐Thiazolidinone/2,4‐Thiazolidinedione–Sulfonamide Hybrids: A Concise Review of Their Design and Pharmacological Significance

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Sulfonamide–thiazolidinone hybrids integrate complementary pharmacophores to generate multifunctional scaffolds with broad pharmacological potential. Their structural versatility supports antimicrobial, antifungal, antioxidant, anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, and enzyme‐inhibitory activities.
Subham Kumar Vishwakarma, Andressa Francielli Bonjorno, Sukhwant Singh, Christian S. Carnero Canales, Jean Leandro dos Santos, Cesar Augusto Roque‐Borda, Fernando Rogério Pavan   +6 more
wiley   +1 more source

Delay of cell growth and loss of stemness by inhibition of reverse transcription in human mesenchymal stem cells derived from dental tissue

Animal Cells and Systems, 2019
The present study investigated the cellular properties in the dental tissue-derived mesenchymal stem cells (DSCs) exposed to nevirapine (NVP), an inhibitor of reverse transcriptase (RTase).
Won-Cheol Lee, Dae-Young Kim, Mi-Jeong Kim, Hyeon-Jeong Lee, Dinesh Bharti, Sung-Ho Lee, Young-Hoon Kang, Gyu-Jin Rho, Byeong-Gyun Jeon   +8 more
doaj   +1 more source

Effect of exposure to clinic-based health education interventions on behavioural intention to prevent mother-to-child transmission of HIV infection

SAHARA-J, 2006
HIV and AIDS incidence among infants in South Africa is on the increase. The uptake of prevention of mother-to-child transmission (PMTCT) interventions is often said to be dependent on the beliefs and educational needs of those requiring PMTCT services ...
Jude Igumbor, Supa Pengpid, Larry Obi
doaj   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3656-3665, October 2026.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Factors influencing plasma nevirapine levels: a study in HIV-infected children on generic antiretroviral treatment in India

, 2011
Background: Nevirapine is an important component of paediatric combination HIV therapy. Adequate drug exposure is necessary in order to achieve long-lasting viral suppression.
Sikhamani, Rajasekaran, Agibothu Kupparam, Hemanth Kumar, Navaneethapandian, Poorana Ganga Devi, Mahalingam, Vasantha, Soundararajan, Lakshmi, Shah, Ira, Ramachandran, Geetha, Swaminathan, Soumya, Perumal Kannabiran, Bhavani, Karunaianandham, Ramesh, Sikhamani, S, Kannabiran, Bhavani P, Navaneethapandian, Poorna Ganga Devi, Karunaianandham, R, Hemanth Kumar, A K, shah, I   +15 more
core   +1 more source

Population Pharmacokinetics of Dolutegravir in Plasma and Cerebrospinal Fluid in Adults Living With HIV

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Characterizing dolutegravir penetration into the central nervous system is important for optimizing human immunodeficiency virus treatment outcomes, yet population‐specific pharmacokinetic data describing cerebrospinal fluid disposition and equilibration kinetics remain lacking.
Mohammed W. Ali, Sam Nightingale, Tracy Kellermann, John Joska, Alan Winston, Saye Khoo, Joseph F. Standing, Eric H. Decloedt, Ahmed A. Abulfathi   +8 more
wiley   +1 more source

Antiretroviral Therapies in Women after Single-Dose Nevirapine Exposure [PDF]

, 2010
Background: Peripartum administration of single-dose nevirapine reduces mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) but selects for nevirapine-resistant virus.
Y. Zheng, Rahim, S., A. Asmelash, E. Hogg, Stringer, E., Alston-Smith, B., Eshleman, S., Rooney, J., S. Rahim, J.S. Currier, C. Kanyama, Asmelash, A., J. McIntyre, K. Wools-Kaloustian, A. Siika, Atwine, D., Schooley, R. T., D. Atwine, Hakim, J., Mellors, J. W., E. Purcelle-Smith, T. Chipato, Conradie, F., Sawe, F., J. Hakim, Siika, A., L. Mohapi, Hosseinipour, M. C., R.T. Schooley, McIntyre, J., Salata, R. A., Mohapi, L., A. Walawander, R. Mngqibisa, Kanyama, C., Shaffer, D., Mngqibisa, R., M.C. Hosseinipour, D. Shaffer, B. Alston-Smith, Wools-Kaloustian, K., Walawander, A., R.A. Salata, Chipato, T., OCTANE A5208 Study Team, Lockman, S., S. Lockman, Currier, J. S., J.W. Mellors, F. Sawe, E. Stringer, Zheng, Y., Purcelle-Smith, E., J. Rooney, Hogg, E., S. Eshleman, F. Conradie, Hughes, M. D., M.D. Hughes   +58 more
core   +1 more source

Docking-MM-GB/SA and ADME screening of HIV-1 NNRTI inhibitor: Nevirapine and its analogues

, 2008
Nevirapine and its synthetic analogues, a class of non-nucleoside inhibitors (NNRTIs) of HIV-1 reverse transcriptase (RT), have been the objective of numerous studies focused to prepare better and safer anti-HIV drugs.
Verma, D., Sengupta, D., Naik, P.K.
core   +2 more sources

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian, Brandon Klein, Farah Abdelmawla, Joe Gomez, Peter L. Anderson, Lane Bushman, Kristina M. Brooks   +6 more
wiley   +1 more source

The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients [PDF]

, 2013
Dr. Fred Stephen Sarfo, The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV ...
SARFO, FRED,STEPHEN
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