Results 21 to 30 of about 15,487 (155)
Molecules, 2022 In this paper, the Y188C mutant HIV-1 reverse transcriptase (Y188CM-RT) target protein was constructed by homology modeling, and new ligands based on nevirapine (NVP) skeleton were designed by means of fragment growth. The binding activity of new ligands
Yan Wang +5 more
doaj +1 more source
Affecting factors to effectiveness of starting therapy in children with hiv infection
Журнал инфектологии, 2015 The purpose of the research – to characterize of the factors that influence the effectiveness of the starting highly activе antiretroviral therapy in children with HIV infection.Materials and methods.
V. B. Denisenko, E. N. Simovanyan
doaj +1 more source
HIV Medicine, EarlyView.Abstract Introduction Antiretroviral therapy (ART) for people living with HIV has led to dramatically reduced mortality and improved life expectancy. This achievement is accompanied by a higher risk for metabolic and other non‐communicable diseases. The role and contribution of various ART regimens to adverse metabolic outcomes are not fully understood.
Melani Ratih Mahanani +7 more
wiley +1 more source
Anti-Retroviral Treatment in dr. Sardjito Central General Hospital Yogyakarta
Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology)Background: Adverse cutaneous drug reactions (ACDRs) affect 2-3% of hospitalized patients globally, wherein approximately 2% (1 in 1,000 cases) accounted for a severe form of cutaneous drug reactions.
Labitta Pachira Aquaira +2 more
doaj +1 more source
Crystals, 2019 Stabilization of specific crystal polymorphs of an active pharmaceutical ingredient is crucial for preventing uncontrollable interconversion of various crystalline forms, which affects physicochemical properties as well as physiological activity.
Mariya A. Kryukova +4 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Objectives Increasing rates of HIV‐1 drug resistance (HIVDR) threaten the effectiveness of antiretroviral therapy (ART) programmes in sub‐Saharan Africa, particularly among children, adolescents and young adults, who face limited treatment options.
Dominic Rauschning +16 more
wiley +1 more source
Frontiers in Analytical ScienceIntroductionA reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the quantitation of nevirapine (NVP) in bulk drug, commercial tablets, and niosome formulations using an Analytical Quality by Design ...
Bwalya A. Witika, Roderick B. Walker
doaj +1 more source
IMPROVING ANTIRETROVIRAL THERAPY IN CHILDREN WITH HIV INFECTION
Детские инфекции (Москва), 2018 The objective — to characterize the effectiveness of different schemes of antiretroviral therapy in children with HIV infection and on the basis of the obtained data to improve of the disease treatment.Patients and Methods: A clinical, immunological and ...
V. B. Denisenko, E. N. Simovanyan
doaj +1 more source
Biomedical Chromatography, Volume 40, Issue 9, September 2026.ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian +6 more
wiley +1 more source
Animal Cells and Systems, 2019 The present study investigated the cellular properties in the dental tissue-derived mesenchymal stem cells (DSCs) exposed to nevirapine (NVP), an inhibitor of reverse transcriptase (RTase).
Won-Cheol Lee +8 more
doaj +1 more source