Results 81 to 90 of about 39,721 (242)

Associations of modern initial antiretroviral therapy regimens with all-cause mortality in people living with HIV in resource-limited settings: a retrospective multicenter cohort study in China

Nature Communications, 2023
Despite the proven virological advantages, there remains some controversy regarding whether first-line integrase strand transfer inhibitors (INSTIs)-based antiretroviral therapy (ART) contributes to reducing mortality of people living with HIV (PLHIV) in
Xinsheng Wu, Guohui Wu, Ping Ma, Rugang Wang, Linghua Li, Yuanyi Chen, Junjie Xu, Yuwei Li, Quanmin Li, Yuecheng Yang, Lijing Wang, Xiaoli Xin, Ying Qiao, Gengfeng Fu, Xiaojie Huang, Bin Su, Tong Zhang, Hui Wang, Huachun Zou   +18 more
doaj   +1 more source

Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection [PDF]

, 2003
Although the pathogenesis of human immunodeficiency virus (HIV) infection and the general virologic and immunologic principles underlying the use of antiretroviral therapy are similar for all HIV-infected persons, there are unique considerations needed ...
Antiretroviral Therapy and Medical Management of HIV-Infected Children, ATMMHC, Health Resources and Services Administration, HRSA, National Institutes of Health, NIH, National Pediatric and Family HIV Resource Center, NPHRC   +3 more
core  

Efavirenz challenge in patients with nevirapine induced Stevens-Johnson Syndrome

Southern African Journal of Infectious Diseases, 2016
Background: Non-nucleoside reverse transcriptase inhibitors (NNRTI) are recommended as part of first-line treatment by the World Health Organisation (WHO) for antiretroviral treatment (ART) naïve subjects.
Thandekile C. Manzini, Bernadett I. Gosnell, Melanie-Anne A. John, Mahomed Y. S. Moosa   +3 more
doaj   +1 more source

A retrospective cohort analysis comparing pregnancy rates among HIV-positive women using contraceptives and efavirenz- or nevirapine-based antiretroviral therapy in Kenya

The Lancet HIV, 2015
SUMMARY Background Given recent concerns of efavirenz reducing the efficacy of contraceptive implants, we sought to determine if pregnancy rates differ among HIV-positive women using various contraceptive methods and efavirenz- or nevirapine-based ...
Rena C. Patel, M. Onono, M. Gandhi, C. Blat, Jill M Hagey, S. Shade, E. Vittinghoff, E. Bukusi, S. Newmann, C. Cohen   +9 more
semanticscholar   +1 more source

Genotype–Specific Safety and Pharmacokinetics of Cannabidiol in Healthy Volunteers

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Cannabidiol (CBD) use has increased in America due to its widespread availability. Cannabidiol is metabolized by multiple polymorphic enzymes including CYP3A, CYP2C9, and CYP2C19. We sought to evaluate the genotype‐specific adverse events and pharmacokinetic profiles of cannabidiol, 7‐OH cannabidiol (an active metabolite), and 7‐COOH ...
Jumar Etkins, Gerald C. So, Jessica Bo Li Lu, Sachiko Koyama, Debora L. Gisch, Ricardo Melo Ferreira, Ying‐Hua Cheng, Kelsey McClara, Joshua Jun, Matthew Miller, Zeruesenay Desta, Michael T. Eadon   +11 more
wiley   +1 more source

Long-term efficacy and safety of nevirapine-containing regimens in virologically suppressed patients: a 17-year follow up

HIV Research & Clinical Practice, 2019
Background: To evaluate long term outcomes in patients maintaining a NVP based regimen for more than 10 years. Materials and methods: Retrospective, multicenter, cohort study including virologically suppressed patients, currently receiving a NVP-based ...
Juan Tiraboschi, Natalia Lattour, Hernando Knobel, Pere Domingo, Esteve Ribera, Daniel Podzamczer   +5 more
doaj   +1 more source

International Normalized Ratio (INR) Increases amongst Two Patients Living with HIV on Warfarin after Being Switched from a Nevirapine to a Dolutegravir-Based Antiretroviral Regimen

Case Reports in Infectious Diseases, 2021
The increased use of dolutegravir-based regimens in the treatment of HIV is unmasking drug interactions, particularly in patients who were previously on nevirapine. Nevirapine is an enzyme inducer and increases the dosing requirements for cytochrome P450
Natalie Sang, Sonak Pastakia, Samuel Nyanje   +2 more
doaj   +1 more source

Has the phasing out of stavudine in accordance with changes in WHO guidelines led to a decrease in single-drug substitutions in first-line antiretroviral therapy for HIV in sub-Saharan Africa? [PDF]

, 2017
This version is the Accepted Manuscript and is published in final edited form as: AIDS. 2017 January 02; 31(1): 147–157. doi:10.1097/QAD.0000000000001307OBJECTIVE: We assessed the relationship between phasing out stavudine in first-line antiretroviral ...
Bor, Jacob, Boulle, A., Brennan, Alana T., Davies, Mary-Ann, de Rekeneire, N., Fatii, G., Fox, M.P., Leroy, V., Prozesky, H., Sikazwe, I., Stinson, K., Tanser, F., Wandelere, G., Wood, R., Wool-Kaloustian, K., Yuannoutsos, C.   +15 more
core   +2 more sources

French‐Speaking Network of Pharmacogenetics (RNPGx) Recommendations for Gene Panel Analysis Through Genotyping or Sequencing in Pharmacogenetics

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background The implementation of pharmacogenetics in clinical practice increasingly relies on multigene panels. Objectives The objective of this study is to develop harmonized recommendations for the design and analytical implementation of multigene pharmacogenetic panels, defining clinically relevant genes and associated regions of interest ...
Nicolas Picard, Estelle Ayme‐Dietrich, Sylvie Quaranta, Tiphaine Adam‐De‐Beaumais, Abd El Kader Ait Tayeb, Hugo Alarcan, Dorra Amor, David Barthelemy, Mouna Ben Sassi, Séverine Cunat, Mouna Daldoul, Hervé Delacour, Marie‐Christine Etienne‐Grimaldi, Xavier Fonrose, Benjamin Hennart, Louis Lebreton, Stephanie Malard, Céline Narjoz, Asma Omezzine, Nicolas Pallet, Léa Payen, Jeanne Petit, Fabienne Thomas, Sameh Trabelsi, Camille Tron, Céline Verstuyft, Paul Vilquin, Jean‐Christophe Boyer, Vincent Haufroid, French‐Speaking Network of Pharmacogenetics (RNPGx)   +29 more
wiley   +1 more source

Should nevirapine be used to prevent mother-to-child transmission of HIV among women of unknown serostatus?

Bulletin of the World Health Organization
At present, HIV testing and counselling during pregnancy represent the key entry point for women to learn their serostatus and for them to access, if they are HIV-positive, specific interventions to reduce mother-to-child transmission (MTCT) of HIV ...
Tin Tin Sint, François Dabis, Claude Kamenga, Nathan Shaffer, Isabelle F. de Zoysa   +4 more
doaj   +1 more source