Results 81 to 90 of about 1,643,238 (264)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Australia’s newest Irish novelist

open access: yes, 2013
Australia’s newest Irish ...
FM Devlin-Glass (15883502)
core  

Shifting the Sand: Replicating Black Powder Grenades

open access: yesEXARC Journal, 2018
Black powder hand grenades are ubiquitous for several European archaeological sites between 1600 AD and 1900 AD. Unfortunately, many archaeological reports only note the presence of hand grenades in artifact inventories, perhaps denoting some minor ...
Stephen Lacey
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

ERA march and rally poster, Seattle, August 23, 1980

open access: yes, 1980
The Equal Rights Amendment (ERA) was introduced in the U. S. Congress for the first time in 1923 and has prompted conversations about the meaning of equality for women and men ever since.
Washington ERA Coalition
core  

Experimental Archaeology: Who Does It, What Is the Use?

open access: yesEXARC Journal, 2019
In two surveys, several people working with experimental archaeology explained what they believe is experimental archaeology. They also described their activities. We asked universities, societies, freelancers and museums. Several adjacent activities are
Roeland P Paardekooper
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Daily New Era - April 1908

open access: yes
The Daily New Era was a daily newspaper in Huntingdon County. A weekly edition of the newspaper was also published, called the New Era Journal. The Daily New Era included current events, personal notes, advertisements from local businesses, and a ...
The Daily New Era
core  

Conference Review: Archaeological Open-Air Museums: Reconstruction and Reenactment – Reality or Fiction?

open access: yesEXARC Journal, 2019
An amazing golden Autumn day greeted us on our first visit to Trzcinica, South Eastern Poland, where last October Terramara Park representatives had been invited to the conference “Archaeological Open-Air Museums: Reconstruction and Reenactment – Reality
Alessia Pelillo
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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