Results 61 to 70 of about 1,460,723 (393)

SARS-CoV-2 variants from COVID-19 positive cases in the Free State province, South Africa from July 2020 to December 2021

Frontiers in Virology, 2022
Since the COVID-19 outbreak emerged, SARS-CoV-2 has continuously evolved into variants with underlying mutations associated with increased transmissibility, potential escape from neutralizing antibodies, and disease severity.
Peter Mwangi, Javan Okendo, Javan Okendo, Milton Mogotsi, Ayodeji Ogunbayo, Olusesan Adelabu, Hlengiwe Sondlane, Makgotso Maotoana, Lutfiyya Mahomed, Molefi Daniel Morobadi, Molefi Daniel Morobadi, Sabeehah Vawda, Sabeehah Vawda, Anne von Gottberg, Anne von Gottberg, Jinal Bhiman, Jinal Bhiman, Houriiyah Tegally, Eduan Wilkinson, Jennifer Giandhari, Sureshnee Pillay, Yeshnee Naidoo, Upasana Ramphal, Tulio de Oliveira, Tulio de Oliveira, Tulio de Oliveira, Armand Bester, Armand Bester, Dominique Goedhals, Dominique Goedhals, Dominique Goedhals, Martin Nyaga   +31 more
doaj   +1 more source

Application of Next Generation Sequencing in Laboratory Medicine

Annals of Laboratory Medicine, 2021
The rapid development of next-generation sequencing (NGS) technology, including advances in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation, has facilitated its wide clinical application in precision medicine.
Y. Zhong, Feng Xu, Jinhua Wu, Jeffrey Schubert, Marilyn M. Li   +4 more
semanticscholar   +1 more source

Adenomyosis pathogenesis: insights from next-generation sequencing

Human Reproduction Update, 2021
BACKGROUND Adenomyosis, characterized by the presence of islands of endometrial tissue surrounded by hypertrophic smooth muscle cells within the myometrium, is one of the most challenging uterine disorders in terms of diagnosis and management ...
S. Bulun, Ş. Yıldız, Mazhar Adli, Jian-jun Wei   +3 more
semanticscholar   +1 more source

High Detection Frequency of Vaccine-Associated Polioviruses and Non-Polio Enteroviruses in the Stools of Asymptomatic Infants from the Free State Province, South Africa

Microorganisms
Enterovirus (EV) infections are widespread and associated with a range of clinical conditions, from encephalitis to meningitis, gastroenteritis, and acute flaccid paralysis.
Milton T. Mogotsi, Ayodeji E. Ogunbayo, Hester G. O’Neill, Martin M. Nyaga   +3 more
doaj   +1 more source

Molecular Characterisation of a Rare Reassortant Porcine-Like G5P[6] Rotavirus Strain Detected in an Unvaccinated Child in Kasama, Zambia

Pathogens, 2020
A human-porcine reassortant strain, RVA/Human-wt/ZMB/UFS-NGS-MRC-DPRU4723/2014/G5P[6], was identified in a sample collected in 2014 from an unvaccinated 12 month old male hospitalised for gastroenteritis in Zambia.
Wairimu M. Maringa, Peter N. Mwangi, Julia Simwaka, Evans M. Mpabalwani, Jason M. Mwenda, Ina Peenze, Mathew D. Esona, M. Jeffrey Mphahlele, Mapaseka L. Seheri, Martin M. Nyaga   +9 more
doaj   +1 more source

Bioinformatics and Next- generation Sequencing [PDF]

Klinicka onkologie, 2015
Next-generation sequencing technologies are currently well-established in the research field and progressively find their way towards clinical applications. Sequencers produce vast amounts of data and therefore bioinformatics methods are needed for processing.
Bořivoj Vojtěšek, Adam Krejci, Petr Müller   +2 more
openaire   +2 more sources

Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

Journal of Clinical Oncology, 2018
Purpose Treatment of advanced non-small-cell lung cancer with immune checkpoint inhibitors (ICIs) is characterized by durable responses and improved survival in a subset of patients.
H. Rizvi, F. Sánchez-Vega, Konnor C. La, W. Chatila, P. Jonsson, D. Halpenny, A. Plodkowski, N. Long, J. Sauter, N. Rekhtman, T. Hollmann, K. Schalper, J. Gainor, R. Shen, A. Ni, K. Arbour, T. Merghoub, J. Wolchok, A. Snyder, J. Chaft, M. Kris, C. Rudin, N. Socci, M. Berger, B. Taylor, A. Zehir, D. Solit, M. Arcila, M. Ladanyi, Gregory Riely, N. Schultz, M. Hellmann   +31 more
semanticscholar   +1 more source

Next generation sequencing [PDF]

, 2013
Informacije pohranjene u DNA sekvenci sadrži vrijedne podatke o tom organizmu, i znajući sekvencu cijelog genoma, u mogućnosti smo razumjeti procese koji se odvijaju u tom biću.
Vučenović, Dunja
core   +2 more sources

Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]

, 2014
Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram, Derveaux, Stefaan, Dong, Wes, Dunne, Jude, Hellemans, Jan, Husain, Syed, Lefever, Steve, Vandesompele, Jo   +7 more
core   +2 more sources

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source