Results 111 to 120 of about 34,540,887 (194)

Regulation of endothelial cell activity and vascular inflammation by shear stress [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Evans, PC, 3rd Micro and Nano Flows Conference (MNF2011)   +1 more
core   +3 more sources

The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis

International Journal of Cell Biology, 2012
The NF-E2-related factor-2 (Nrf2) is a transcription factor which regulates the major cellular defense systems and thereby contributes to the prevention of many diseases including cancer. Selenium deficiency is associated with a higher cancer risk making
Regina Brigelius-Flohé, Mike Müller, Doris Lippmann, Anna Patricia Kipp   +3 more
doaj   +1 more source

Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments

MedComm, Volume 7, Issue 10, October 2026.
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma, Xiaoxuan Zhang, Pujun Zhao, Jiaxin Yang, Zhihao Li, Xiaoyang Han, Yixuan Wang, Zhenzhen Cui, Nian Liu, Min Li   +9 more
wiley   +1 more source

Repeated Moderate and Severe Heat Exposure Has Divergent Effects on Skeletal Muscle Mitochondrial, Proteostatic and Neuromuscular Outcomes in Mice

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Aim Repeated heat exposure may promote adaptive remodeling or cumulative tissue burden depending on thermal dose, but its graded molecular and functional consequences during recovery remain unclear. We examined whether repeated moderate (39°C) and severe (41°C) whole‐body hyperthermia produce distinct skeletal muscle trajectories involving ...
Cansu Yakin, Cihan Suleyman Erdogan, Fatma Ozge Tuncel, Yunus Kosif, Bayram Yilmaz   +4 more
wiley   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source

Nrf2 and NF-κB and Their Concerted Modulation in Cancer Pathogenesis and Progression

, 2010
Reactive oxygen species, produced by oxidative stress, are implicated in the initiation, promotion, and malignant conversion of carcinogenesis through activation/suppression of redox-sensitive transcription factors.
Mierla, Minelli, Bellezza
core   +1 more source

E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities

Liver International, Volume 46, Issue 10, October 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh, Yelin Jeong, Young Hoon Jung, Young Un Kim, HyunJoon Gi, Do‐Wan Kim, Young Du Choi, Sang Bae Lee, KyeongJin Kim   +8 more
wiley   +1 more source

Correlation between the concentration of nuclear NF-kB and protein expression of Nrf2 in peripheral blood mononuclear cells of moderate and heavy smokers.

, 2013
NF-kB was measured in nuclear extracts of PBMC utilizing recombinant p65 as a reference. Data on protein expression of Nrf2 derived from Western blot analysis and are expressed as the density ratio of target to control (Beta-actin) in arbitrary units ×10.
Giovanni Faccini (42978), Mattia Cominacini (335263), Chiara Mozzini (335264), Anna Fratta Pasini (335261), Chiara Stranieri (218583), Stefania Manfro (218586), GianCesare Guidi (368691), Andrea Pasini (17809), Ulisse Garbin (218579), Fabio Lugoboni (65824), Luciano Cominacini (335266)   +10 more
core   +1 more source

Regulation of NRF2, AP‐1 and NF‐κB by cigarette smoke exposure in three‐dimensional human bronchial epithelial cells

, 2019
Cigarette smoke (CS) is a complex mixture of chemicals and interacts with various physiological processes. We previously reported that nuclear factor erythroid 2-related factor 2 (NRF2) was the most sensitive transcription factor to aqueous CS extract ...
Ito, Shigeaki, Shinkichi Ishikawa, Ishikawa, Shinkichi, Kazushi Matsumura, Tadashi Hirata, Matsumura, Kazushi, Hirata, Tadashi, Kanae Ishimori, Takashi Sekine, Katsuhiko Muraki, Muraki, Katsuhiko, Ishimori, Kanae, Sekine, Takashi, Shigeaki Ito   +13 more
core   +1 more source

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

, 2005
Resveratrol (3,4',5-trihydroxy stilbene), a phytoalexin found in the skin and seeds of grapes, has been reported to possess antiinflammatory. anticarcinogenic. and antioxidant activities.
Li, Mei-Hua, Chen, Chu-Yue, Jang, Jung-Hee, Surh, Young-Joon   +3 more
core   +1 more source