Results 121 to 130 of about 30,847 (205)

Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis [PDF]

, 2016
Systemic biomarkers of oxidative stress can be relevant for assessment of psoriasis severity, for prediction of the outcome of therapy and of the development of comorbidities.
Cavaliere, Arturo, Palmery, Maura, Peluso, Ilaria   +2 more
core   +2 more sources

Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism [PDF]

, 2016
Kolaviron is a mixture of bioflavonoids found in the nut of the West African edible seed Garcinia kola, and it has been reported to exhibit a wide range of pharmacological activities.
Abdelmeneim El-Bakoush, BL Fiebich, E Polazzi, EO Farombi, EO Farombi, EO Farombi, H Miyagishi, HM Gao, J Kim, JE Yuste, JO Nwankwo, K Koh, M Dumont, M Sandberg, ML Block, MM Iwu, MM Iwu, NG Innamorato, NG Innamorato, OA Olajide, OJ Olajide, Olumayokun A. Olajide, OO Igado, PJ Syapin, R Foresti, R Velagapudi, Ravikanth Velagapudi, S Lee, Samuel A. Onasanwo, SB Olaleye, SO Abarikwu, SO Abarikwu, SO Abarikwu, UP Okorji, V Zujovic, W Li, W Ratajczak-Wrona   +36 more
core   +1 more source

The Nrf2/HO-1 Pathway Mediates the Antagonist Effect of L-Arginine On Renal Ischemia/Reperfusion Injury in Rats

Kidney & Blood Pressure Research, 2017
Background/Aims: Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress is involved in the development of acute renal injury, which can be reversed by supplementation with L-arginine, a precursor of nitric
Fei Tong, Xinmei Zhou
doaj   +1 more source

IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. [PDF]

, 2018
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct and predominant types of human lung cancer. IκB kinase α (IKKα) has been shown to suppress lung SCC development, but its role in ADC is unknown.
Hu, Yinling, Johnson, Peter F, Karin, Michael, Ma, Buyong, Nussinov, Ruth, Schrump, David S, Song, Na-Young, Su, Ling, Sun, Zhonghe, Wang, Zining, Willette-Brown, Jami, Wu, Xiaolin, Xi, Sichuan, Xia, Xiaojun, Zhu, Feng   +14 more
core   +1 more source

Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice [PDF]

, 2018
Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models.
Cózar Bernal, María José, González Rodríguez, María Luisa, Motilva Sánchez, Virginia, Rabasco Álvarez, Antonio María, Rodríguez Luna, Azahara María, Talero Barrientos, Elena Mª, Ávila Román, Francisco Javier   +6 more
core   +1 more source

3-Bromo-4,5-dihydroxybenzaldehyde Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

Marine Drugs, 2017
A natural bromophenol found in seaweeds, 3-bromo-4,5-dihydroxybenzaldehyde (BDB), has been shown to possess antioxidant effects. This study aimed to investigate the mechanism by which BDB protects skin cells subjected to oxidative stress.
Ki Cheon Kim, Yu Jae Hyun, Susara Ruwan Kumara Madduma Hewage, Mei Jing Piao, Kyoung Ah Kang, Hee Kyoung Kang, Young Sang Koh, Mee Jung Ahn, Jin Won Hyun   +8 more
doaj   +1 more source

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. [PDF]

, 2014
An inherited deficiency of the mitochondrial protein frataxin causes Friedreich's ataxia (FRDA); the mechanism by which this deficiency triggers neuro- and cardio-degeneration is unclear.
Cortopassi, Gino, Hayashi, Genki, Newman, John W, Pedersen, Theresa L, Pook, Mark, Shen, Yan   +5 more
core   +1 more source

The Nrf2 Pathway Alleviates Overloading Force-Induced TMJ Degeneration by Downregulating Oxidative Stress Reactions

Journal of Inflammation Research, 2023
Minglu Xu,1,2,* Lingli Fang,1,2,* Qin Xue,1,2 Xuyang Zhang,1,2 Yao He1,3 1Department of Orthodontics, Stomatological Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Chongqing Key Laboratory of Oral Disease and ...
Xu M, Fang L, Xue Q, Zhang X, He Y
doaj  

The Yin and Yang of Nrf2-Regulated Selenoproteins in Carcinogenesis

International Journal of Cell Biology, 2012
The NF-E2-related factor-2 (Nrf2) is a transcription factor which regulates the major cellular defense systems and thereby contributes to the prevention of many diseases including cancer. Selenium deficiency is associated with a higher cancer risk making
Regina Brigelius-Flohé, Mike Müller, Doris Lippmann, Anna Patricia Kipp   +3 more
doaj   +1 more source

Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacological activation of Nrf2 (NF-E2-related factor 2)

, 2017
Funding: Supported by grants MR/J001465/1 (JDH, MLJA, JFD and RJMcC) and MR/N009851/1 (JDH, MLJA, ATD-K and DJH) from the Medical Research Council of the UK and grants from Stony Brook Foundation and Reata Pharmaceuticals, Inc. (TH) Background & Aims:  Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress.
Sharma, Ritu S., Harrison, David J., Kisielewski, Dorothy, Cassidy, Diane M., McNeilly, Alison D., Gallagher, Jennifer R., Walsh, Shaun V., Honda, Tadashi, McCrimmon, Rory J., Dinkova-Kostova, Albena T., Ashford, Michael L.J., Dillon, John F., Hayes, John D.   +12 more
openaire   +2 more sources