Results 171 to 180 of about 30,847 (205)

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in autophagy-induced hepatocellular carcinoma

Clinica Chimica Acta, 2020
Autophagy, an evolutionarily conserved catabolic process, is the most important pathogenic events in the development and progression of liver diseases. Deregulation of Nrf2 is proposed to play a key pathogenic role in hepatocellular carcinoma (HCC). Under certain pathophysiological conditions, such as oxidative stress, impaired autophagy is accompanied
Juan Zhou   +10 more
openaire   +2 more sources

Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer

Life Sciences, 2020
Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that can regulate downstream target gene expression. Kelch-like ECH-associated protein 1 (Keap1) negatively regulates Nrf2 activation and translocation to target its 26S proteasomal degradation. It has been widely reported that the Keap1/Nrf2 pathway is associated with
Zhi, Zeng   +9 more
openaire   +2 more sources

PP019. A new player in preeclampsia: The NF-E2-related factor 2 (NRF2)

Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2013
Preeclampsia PE is characterized by diminished antioxidant capacity. These enzymes are mainly regulated via the transcription factor Nrf2.PE is associated with an increase in Nrf2 activity. Nrf2 involves also in the vascular homeostasis during PE. Respective hemodisturbances have been associated with impaired invasion of the extravillous trophoblast ...
Nisreen, Kweider   +7 more
openaire   +2 more sources

Transcription factor Nrf2 (NF-E2 Related Factor 2) enhances myeloid-derived suppressor cell (MDSC) accumulation and tumor progression (46.13)

The Journal of Immunology, 2012
Abstract Previous studies have shown that MDSC block adaptive anti-tumor immunity by producing high levels of oxidizing agents such as reactive oxygen species (ROS), nitric oxide (NO), and peroxynitrite. Despite high levels of the toxic oxidizing agents, MDSC survive and suppress anti-tumor immunity.
Daniel Beury   +2 more
openaire   +1 more source

Immunohistochemical study of NF-E2-related factor 2 (Nrf2) in an end-to-end anastomosis of the rat carotid artery

Journal of Cranio-Maxillofacial Surgery, 2012
The detailed process and underlying mechanism of stenosis following microvascular anastomoses remains unclear. NF-E2-related factor 2 (Nrf2), is a pleiotropic regulator of cell survival and plays a crucial role in modulating acute inflammatory response.
Lin, Zhu   +4 more
openaire   +2 more sources

Expression of NF-E2-related factor 2 (Nrf2) in the basilar artery after experimental subarachnoid hemorrhage in rabbits: A preliminary study

Brain Research, 2010
It has been suggested that the pathogenesis of vasospasm is complex including endothelial damage, oxidative stress, inflammatory damage, and the accumulation of toxic metabolites. Recently, a growing body of evidence indicates that nuclear factor erythroid 2-related factor 2 (Nrf2) plays a unique role in many physiological stress processes.
Xu-Dong, Zhao   +7 more
openaire   +2 more sources

Pterostilbene Is More Potent than Resveratrol in Preventing Azoxymethane (AOM)-Induced Colon Tumorigenesis via Activation of the NF-E2-Related Factor 2 (Nrf2)-Mediated Antioxidant Signaling Pathway

Journal of Agricultural and Food Chemistry, 2011
Inflammatory bowel diseases have been a risk factor of colorectal cancer (CRC). The reactive oxygen species (ROS) generated by inflammatory cells create oxidative stress and contribute to neoplastic transformation, proliferation, and even metastasis. Previously, resveratrol (RS) and pterostilbene (PS) had been reported to prevent chemical-induced colon
Yi-Siou, Chiou   +6 more
openaire   +2 more sources

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