Results 241 to 250 of about 12,632,659 (295)

Requirement for NF-kappa B in osteoclast and B-cell

, 1997
NF-kappa B is a family of related, dimeric transcription factors that are readily activated in cells by signals associated with stress or pathogens. These factors are critical to host defense, as demonstrated previously with mice deficient in individual subunits of NF-kappa B.
FRANZOSO G., CARLSON L., XING L., POLJAK L., SHORES E.W., BROWN K.D., LEONARDI, ANTONIO, TRAN T., BOYCE B.F., SIEBENLIST U.   +9 more
core   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

microRNA and NF-kappa B

2015
Nuclear Factor kappa B (NF-κB) plays important roles in regulation of countless cellular functions, including cell cycle and apoptosis. As a versatile transcription factor, NF-κB is a target of a large amount of miRNAs. Abnormal NF-κB activity is frequently associated with an abnormal level of miRNAs, which is found to play critical roles in disease ...
Ye, Yuan, Lingying, Tong, Shiyong, Wu
openaire   +2 more sources

Redox Regulation of NF-kappa B Activation

Free Radical Biology and Medicine, 1997
Cytosolic reactions of the nuclear factor kappa B/inhibitor (NF-kappaB/IkappaB) complex leading to its activation, NF-kappaB translocation into the nucleus, DNA binding, and transactivation have been described with some degree of clarity, but the upstream processes that stimulate those cytosolic reactions remain obscure.
L, Flohé, R, Brigelius-Flohé, C, Saliou, M G, Traber, L, Packer   +4 more
openaire   +2 more sources

NF-kappa B p65 transactivation domain is involved in the NF-kappa B-inducing kinase pathway.

Biochemical and biophysical research communications, 2003
NF-kappa B-inducing kinase (NIK) is involved in the signal transduction pathway leading to the NF-kappa B activation. In this report, we demonstrate that the NIK-mediated NF-kappa B activation involves the transactivation (TA) domain of p65 subunit of NF-kappa B and the nuclear translocation of IKK alpha.
Xu, Jiang, Naoko, Takahashi, Kiichiro, Ando, Takanobu, Otsuka, Toshifumi, Tetsuka, Takashi, Okamoto   +5 more
openaire   +2 more sources

Promoter of the human NF-kappa B p50/p105 gene. Regulation by NF-kappa B subunits and by c-REL

The Journal of Immunology, 1993
Abstract NF-kappa B is a transcription factor involved in the regulation of numerous genes encoding proteins involved in immune function, in inflammation or in cellular growth control. NF-kappa B is typically characterized as a heterodimer of a 50-kDa subunit (p50) and a 65-kDa (p65) subunit.
P C, Cogswell, R I, Scheinman, A S, Baldwin   +2 more
openaire   +2 more sources

NF-kappa B in allograft rejection.

Hepatobiliary & pancreatic diseases international : HBPD INT, 2004
Nuclear factor-kappa B (NF-kappa B) as an essential transcription factor in the control of expression of the cytokine-induced genes in immune and inflammatory responses regulates cytokines in allograft rejection. In this review, we summarize the general properties of NF-kappa B and the principal findings to shed new light on transplantation.
Jian-Feng, Wei, Shu-Sen, Zheng
openaire   +1 more source

Rel/NF-kappa B transcription factors and cancer

International Journal of Oncology, 1997
The transcription factors of the Rel/NF-kappa B family play a central role in immune regulation. In addition, they may be involved in the pathogenesis of certain tumors, especially those of hematopoietic origin. In this review evidence is summarized indicating an association between dysregulated NF-kappa B-dependent gene expression and tumorigenesis ...
M, Neumann, R, Marienfeld, E, Serfling
openaire   +2 more sources

[NF-kappa B and cancers].

Bulletin et memoires de l'Academie royale de medecine de Belgique, 2000
The NF-kappa B transcription factor controls the expression of many genes, including genes regulating cell proliferation or survival and involved in oncogenesis. We showed that many breast cancers express high levels of the NF-kappa B inhibitor p100.
openaire   +1 more source

NF‐kappa B is required for the development of tumor spheroids

Journal of Cellular Biochemistry, 2009
AbstractTumor cells cultured in three‐dimensional models provide a more realistic and biologically meaningful analysis of the initial phases of cancer development and drug resistance. Several studies have demonstrated that culture of cancer cells in three dimensions induces cellular resistance to a variety of anti‐neoplastic drugs by poorly understood ...
J C, Gallardo-Pérez, M, Espinosa, G, Ceballos-Cancino, A, Daniel, S, Rodríguez-Enríquez, A, Aviles, R, Moreno-Sánchez, J, Melendez-Zajgla, V, Maldonado   +8 more
openaire   +2 more sources

Mutational analysis of the p50 subunit of NF-kappa B and inhibition of NF-kappa B activity by trans-dominant p50 mutants

Journal of Virology, 1993
The NF-kappa B family of DNA-binding proteins regulates the expression of many cellular and viral genes. Each of these proteins has an N-terminal region that is homologous to the c-Rel proto-oncogene product, and this Rel homology region defines both DNA binding and protein dimerization properties of the individual proteins.
P, Bressler, K, Brown, W, Timmer, V, Bours, U, Siebenlist, A S, Fauci   +5 more
openaire   +2 more sources