Results 91 to 100 of about 99,548 (294)

Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune‐regulatory cells in pain is unknown. Our objective was to identify synovial innate immune
Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton, on behalf of the WOREO Knee Study Group   +14 more
wiley   +1 more source

Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

Фармакокинетика и Фармакодинамика, 2016
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (
T. A. Antipova, I. O. Logvinov, S. V. Nikolaev, S. V. Kruglov, A. V. Tarasiuk, P. I. Antipov, T. A. Gudasheva, S. B. Seredenin   +7 more
doaj  

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Evaluating the persistence and utility of five wild Vitis species in the context of climate change

Molecular Ecology, Volume 31, Issue 24, Page 6457-6472, December 2022., 2022
Abstract Crop wild relatives (CWRs) have the capacity to contribute novel traits to agriculture. Given climate change, these contributions may be especially vital for the persistence of perennial crops, because perennials are often clonally propagated and consequently do not evolve rapidly.
Jonas A. Aguirre‐Liguori, Abraham Morales‐Cruz, Brandon S. Gaut   +2 more
wiley   +1 more source

Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.

PLoS ONE, 2014
The role of nerve growth factor (NGF) in liver injury induced by bile duct ligation (BDL) remains elusive. This study aimed to investigate the relationship between inflammation and hepatic NGF expression, to explore the possible upstream molecules up ...
Ming-Shian Tsai, Yu-Chun Lin, Cheuk-Kwan Sun, Shih-Che Huang, Po-Huang Lee, Ying-Hsien Kao   +5 more
doaj   +1 more source

Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium

BMC Musculoskeletal Disorders, 2019
Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients.
Shotaro Takano, Kentaro Uchida, Makoto Itakura, Dai Iwase, Jun Aikawa, Gen Inoue, Manabu Mukai, Masayuki Miyagi, Kosuke Murata, Hiroyuki Sekiguchi, Masashi Takaso   +10 more
doaj   +1 more source

NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS). [PDF]

PLoS ONE, 2013
Nerve growth factor (NGF) is the founding member of the polypeptide neurotrophin family responsible for neuronal differentiation. To determine whether the effects of NGF rely upon novel Integrative Nuclear FGF Receptor-1 (FGFR1) Signaling (INFS) we ...
Yu-Wei Lee, Ewa K Stachowiak, Barbara Birkaya, Christopher Terranova, Mariolina Capacchietti, Peter Claus, John M Aletta, Michal K Stachowiak   +7 more
doaj   +1 more source

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources

Do Corporate Governance Mechanisms Help to Reduce Carbon Emissions? Some Empirical Evidence on Listed Companies in France, Germany, the United Kingdom, and Japan

Business Strategy and the Environment, EarlyView.
ABSTRACT Climate change is one of the greatest challenges facing humanity today. In this paper, we analyze the role of firms in mitigating climate change through their model of corporate governance. We examine the impact of key organizational control and incentive mechanisms on firms' carbon emission intensity.
Cécile Cezanne, Gaye Del Lo, Yves Kassi, Sandra Rigot   +3 more
wiley   +1 more source