Results 91 to 100 of about 108,193 (313)
AIMS NeurosciencePurpose The cyclic AMP response element–binding protein (CREB) and nerve growth factor (NGF) have been proposed as key modulators of brain health and are involved in synaptic plasticity.
Roya. Askari +5 more
doaj +1 more source
Transforming growth factor-β stimulates nerve growth factor production in osteoarthritic synovium
BMC Musculoskeletal Disorders, 2019 Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients.
Shotaro Takano +10 more
doaj +1 more source
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death [PDF]
, 1997 Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that trkB (¿/¿) mice have a significant
Alcántara Horrillo, Soledad +5 more
core +1 more source
3D Hydrogel Cell Cultures and Their Biomedical Applications
Advanced NanoBiomed Research, EarlyView.The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai +7 more
wiley +1 more source
Фармакокинетика и Фармакодинамика, 2017 Dimeric dipeptide mimetic 1st loop of NGF GK-6 (10-6M) activating as phosphatidylinozitol 3-kinase/Akt and mitogen-activated protein kinase MEK/MAPK/ERK) signaling cascades causes PC12 cell differentiation into neuron-like cells. At the same time dimeric
T. A. Antipova +5 more
doaj
Version control of pathway models using XML patches [PDF]
, 2009 <p>Background: Computational modelling has become an important tool in understanding biological systems such as signalling pathways. With an increase in size complexity of models comes a need for techniques to manage model versions and their ...
Orton, R., Saffrey, P.
core +4 more sources
Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks
British Journal of Clinical Pharmacology, EarlyView.The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou +2 more
wiley +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2018 Background & Aims: Aging gastric mucosa has increased susceptibility to injury and delayed healing owing to impaired angiogenesis, but the mechanisms are not fully known. We examined whether impairment of angiogenesis in aging gastric mucosa is caused by
Amrita Ahluwalia +5 more
doaj +1 more source
Role of nerve growth factor in the development of rat sympathetic neurons in vitro. I. Survival, growth, and differentiation of catecholamine production [PDF]
, 1977 The effect of nerve growth factor (NGF) on the development of cholinergic sympathetic neurons was studied in cultures grown either on monolayers of dissociated rat heart cells or in medium conditioned by them.
Chun, Linda L. Y., Patterson, Paul H.
core +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source