Results 71 to 80 of about 94,176 (342)

Simultaneous effect of aerobic exercise and nanocurcumin supplementation on the expression of BDNF and NGF genes in rats with brain tumor [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
Introduction:  Increased nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) signaling in neuroblastoma cells may represent an autocrine system to support cancer growth, invasion, and metastasis.
Salmah Mohamadi, Hosein Shirvani, Mehdi Roozbahani, Masoud Rahmati   +3 more
doaj  

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Therapeutic Effects of Simultaneous Delivery of Nerve Growth Factor mRNA and Protein via Exosomes on Cerebral Ischemia

Molecular Therapy: Nucleic Acids, 2020
Stroke is the leading neurological cause of death and disability all over the world, with few effective drugs. Nerve growth factor (NGF) is well known for its multifaceted neuroprotective functions post-ischemia.
Jialei Yang, Shipo Wu, Lihua Hou, Danni Zhu, Shimin Yin, Guodong Yang, Yongjun Wang   +6 more
doaj   +1 more source

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA

Journal of Cell Biology, 1992
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are molecules which regulate the development and maintenance of specific functions in different populations of peripheral and central neurons, amongst them sensory neurons of neural ...
M. Meyer, I. Matsuoka, Cynthia Wetmore, L. Olson, H. Thoenen   +4 more
semanticscholar   +1 more source

NGF-PC-AD connection [PDF]

, 2013
In an elegant manner Viviana Triaca presented in this volume of Adipobiology her Homage to Rita Levi-Montalcini highlighting the significance of nerve growth factor (NGF) in the molecular mechanisms of Alzheimer's disease (AD).
Chaldakov, George N.; Medical University of Varna, Dikranian, Krikor; Washington University in St. Louis   +1 more
core   +1 more source

Exploiting Ferroelectric and Spintronic Dynamics for Neural Network Computation

Advanced Intelligent Systems, EarlyView.
Ferroelectric and spintronic devices, relying on the control of polarization and magnetization, offer intrinsically fast, durable, energy‐efficient, and low‐latency building blocks for analog in‐memory computing. The hysteretic dynamics of an order parameter are leveraged to provide nonvolatile, multistate memory and nonlinear switching. Brain‐inspired
Dashiell Harrison, Kevin Nadaud, Josquin Harrison, Guillaume F. Nataf, Laura Bégon‐Lours   +4 more
wiley   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

A study on the mnemotropic and antidepressant-like effects of the low-molecular-weight mimetic of nerve growth factor, dipeptide GK-2, in experimental ischemic stroke

Фармакокинетика и Фармакодинамика
Relevance. The nerve growth factor (NGF), possessing neuroprotective and neuroregenerative properties, holds promise for the development of medications for the treatment of post-stroke conditions. At the Federal Research Center for Innovator and Emerging
P. Yu. Povarnina, N. M. Sazonova, D. M. Nikiforov, T. A. Gudasheva, V. L. Dorofeev   +4 more
doaj   +1 more source

NGF Receptor Expression in Sensory Neurons Develops Normally in Embryos Lacking NGF [PDF]

, 1995
Numerous in vivo and in vitro studies have shown that NGF increases the expression of its receptors, p75 and TrkA, in NGF-responsive cell lines and in NGF-responsive neurons of the developing and mature nervous system.
Nishimura, Merry, Phillips, Heidi, Davies, Alun M., Wyatt, Sean   +3 more
core   +1 more source