Results 71 to 80 of about 137,103 (391)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia

Journal of Inflammation Research, 2021
Hao-Kuang Wang,1,2 Jui-Sheng Chen,1,3,4 Chien-Yu Hsu,1 Yu-Ting Su,5 Tzu-Ching Sung,2 Cheng-Loong Liang,1,6 Aij-Lie Kwan,3,7 Cheng-Chun Wu6 1Department of Neurosurgery, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan; 2School of Medicine for ...
Wang HK, Chen JS, Hsu CY, Su YT, Sung TC, Liang CL, Kwan AL, Wu CC   +7 more
doaj  

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Agostinelli, Enzo, Altissimi, Giancarlo, Artico, Marco, Bardella, Lia, Giangaspero, Felice, Minni, Antonio, Parnigotto, Pier Paolo, Pastore, Francesco Saverio, Spoletini, Marialuisa, Taurone, Samanta, Tombolini, Mario, Wierzbicki, Venceslao   +11 more
core   +1 more source

NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways

BioMed Research International, 2014
As a well-known neurotrophic factor, nerve growth factor (NGF) has also been extensively recognized for its acceleration of healing in cutaneous wounds in both animal models and randomized clinical trials.
Ji-Cai Chen, B. Lin, Hou-Wen Hu, Cai Lin, Wenxu Jin, Fa-Biao Zhang, Yan-An Zhu, Cai-jiao Lu, Xiaojie Wei, Rui-jie Chen   +9 more
semanticscholar   +1 more source

Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights

American Journal of Hematology, EarlyView.
CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin, Bruno Paiva, Irene M. Ghobrial, Salomon Manier   +3 more
wiley   +1 more source

Trim17, novel E3 ubiquitin-ligase, initiates neuronal apoptosis [PDF]

, 2010
Accumulating data indicate that the ubiquitin-proteasome system controls apoptosis by regulating the level and the function of key regulatory proteins. In this study, we identified Trim17, a member of the TRIM/RBCC protein family, as one of the critical ...
A Bobba, A Brunet, A Lipkin, A Reymond, AP Aalto, B Pettmann, CM Knudson, CM Pickart, DA Cross, DA Cross, DA Linseman, DP Martin, E Towers, F Jaudon, G Lutfalla, G Meroni, GV Putcha, I Lassot, I Robbins, J Gilley, J Ham, J Ham, J Whitfield, J Yuan, JX Comella, KA Wood, L Swainson, L Vanhille, M Broemer, M Kristiansen, M M Magiera, M Sardiello, MH Glickman, N Canu, R Bhat, R Rahmeh, R Sadoul, RJ Youle, S Desagher, S Desagher, S Mora, S Ogawa, SJ Riedl, SJ Thompson, SR D'Mello, SR Datta, T Urano, TM Miller, TM Miller, V Arce, V Hongisto, Y Du, Z Xia   +52 more
core   +5 more sources

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

The effect of nerve growth factor on supporting spatial memory depends upon hippocampal cholinergic innervation

Translational Psychiatry, 2021
Nerve growth factor (NGF) gene therapy has been used in clinical trials of Alzheimer’s disease. Understanding the underlying mechanisms of how NGF influences memory may help develop new strategies for treatment.
Wei Zheng Eu, Yu-Ju Chen, Wei-Ting Chen, Kuan-Yu Wu, Cheng-Yu Tsai, Sin-Jhong Cheng, Roderick N. Carter, Guo-Jen Huang   +7 more
doaj   +1 more source

Towards a nonequilibrium Green's function description of nuclear reactions: one-dimensional mean-field dynamics [PDF]

, 2010
Nonequilibrium Green's function methods allow for an intrinsically consistent description of the evolution of quantal many-body body systems, with inclusion of different types of correlations.
Aichelin, Arnau Rios, Balzer, Baym, Bertsch, Bonasera, Bonche, Botermans, Bożek, Brent Barker, Breuer, Cassing, Dahlen, Danielewicz, Danielewicz, Danielewicz, Dickhoff, Effenberger, Feit, Flocard, Frensley, Gasenzer, Grangé, Greiner, Haug, Hillery, Ivanov, Juchem, Kadanoff, Kusnezov, Kwong, Köhler, Köhler, Köhler, Köhler, Köhler, Köhler, Lacroix, Lindner, Luo, Mark Buchler, Martínez, Messiah, Morawetz, Márk, Negele, Omnès, Ono, Pawel Danielewicz, Pfitzner, Reinhard, Ring, Simenel, Tang, Thouless, Tohyama, Tohyama, Tohyama, Tohyama, Umar, Vacchini, Wong   +61 more
core   +2 more sources

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source