Results 91 to 100 of about 137,103 (391)

Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA

Journal of Cell Biology, 1992
Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are molecules which regulate the development and maintenance of specific functions in different populations of peripheral and central neurons, amongst them sensory neurons of neural ...
M. Meyer, I. Matsuoka, Cynthia Wetmore, L. Olson, H. Thoenen   +4 more
semanticscholar   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Up-regulation of nerve growth factor in cholestatic livers and its hepatoprotective role against oxidative stress.

PLoS ONE, 2014
The role of nerve growth factor (NGF) in liver injury induced by bile duct ligation (BDL) remains elusive. This study aimed to investigate the relationship between inflammation and hepatic NGF expression, to explore the possible upstream molecules up ...
Ming-Shian Tsai, Yu-Chun Lin, Cheuk-Kwan Sun, Shih-Che Huang, Po-Huang Lee, Ying-Hsien Kao   +5 more
doaj   +1 more source

High frequency repetitive transcranial magnetic stimulation to the left dorsolateral prefrontal cortex modulates sensorimotor cortex function in the transition to sustained muscle pain [PDF]

, 2019
Based on reciprocal connections between the dorsolateral prefrontal cortex (DLPFC) and basal-ganglia regions associated with sensorimotor cortical excitability, it was hypothesized that repetitive transcranial magnetic stimulation (rTMS) of the left ...
De Martino, Enrico, Graven-Nielsen, Thomas, Petrini, Laura, Schabrun, Siobhan M., Seminowicz, David A.   +4 more
core   +3 more sources

Decreased mRNA and Protein Expression of BDNF, NGF, and their Receptors in the Hippocampus from Suicide: An Analysis in Human Postmortem Brain

Clinical Medicine Insights: Pathology, 2013
Despite the devastating effect of suicide on numerous lives, there is still a lack of knowledge concerning its neurochemical aspects. There is increasing evidence that brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in
R. Banerjee, A. Ghosh, B. Ghosh, S. Bhattacharyya, A. Mondal   +4 more
semanticscholar   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source

Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth. [PDF]

, 1987
Neuronal responses to extracellular matrix (ECM) constituents are likely to play an important role in nervous system development and regeneration. We have studied the interactions of a neuron-like rat pheochromocytoma cell line, PC12, with ECM protein ...
Damsky, CH, Reichardt, LF, Tomaselli, KJ
core  

Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals [PDF]

, 2015
This is an accepted manuscript of an article published by Springer in European Journal of Applied Physiology on 04/04/2015, available online: https://doi.org/10.1007/s00421-015-3164-2 The accepted version of the publication may differ from the final ...
AC Shore, Army Medical surveillance activity, AT Koutsavlis, B Endrich, B Waeber, BJ Kim, C Cardillo, C Cardillo, CC Ungley, CC Ungley, Clare M. Eglin, CM Stein, CM Stein, CR Anderson, CS Thompson-Torgerson, D Bylund, D Miller, DA Rosenbaum, DF Kahn, DL Feairheller, DS Jones, DW DeGroot, E Clark, E Mata-Greenwood, FSC Golden, GA Conway, HA Daanen, HC Parkington, HP Rang, J Gainer, J Jia, J Jia, J Lundberg, James R. House, JE Burgess, JE Ramsay, JM Johnson, JP Noon, K Hope, K Komori, K Sauerstein, KK Griendling, KW Russell, L Ekenvall, L Kalinowski, LA Holowatz, LA Holowatz, M Honda, M Roustit, M Schmelz, M Shibasaki, MA Chotani, MA Chotani, MA Hashmi, Matthew J. Maley, ME Pueyo, Michael J. Tipton, MJ Easter, MJ Maley, MS Taylor, N Melikian, O Wilson, RF Furchgott, RG Hendry, RT Grant, RT Grant, SJ Duffy, SJ Morris, SJ Sarnoff, SR Bailey, T Lewis, TJ Cleophas, TM Mäkinen, WH Candler   +73 more
core   +4 more sources