Results 81 to 90 of about 94,176 (342)

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

APP Regulates NGF Receptor Trafficking and NGF-Mediated Neuronal Differentiation and Survival [PDF]

, 2013
National Institutes of Health [R01AG038710, R01AG021173, R01AG044420, R01NS046673, R01AG031893, R21AG041934, R21NS083908]; Alzheimer's Association; National Natural Science Foundation of China [81225008, 81161120496]; Fundamental Research Funds for the ...
Chen, Yaomin, Zhang, Yun-Wu, Yun Liu, Yun-wu Zhang, Huaxi Xu, Yaomin Chen, Liu, Yun, Liao, Francesca-Fang, Francesca-Fang Liao, Zhao, Yingjun, 张云武, Yingjun Zhao, Xu, Huaxi   +12 more
core   +1 more source

Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The high cost of cultivation media remains one of the barriers to the commercialization of cultivated meat. Current serum‐free media reduce reliance on fetal bovine serum but only achieve modest cost savings. Especially at larger scales (> 20 m3), pharmaceutical‐grade amino acids and recombinant proteins remain major cost drivers.
Jelle C. Hoek, Jean‐Marc Daran, Marieke E. Klijn, Marcel A. Vieira‐Lara   +3 more
wiley   +1 more source

Effects of Anti-Nerve Growth Factor Antibody on Symptoms in the NC/Nga Mouse, an Atopic Dermatitis Model

Journal of Pharmacological Sciences, 2005
Nerve growth factor (NGF) is an important substance in the skin, where it can modulate nerve maintenance and repair. However, the direct link between NGF and pruritic disease such as atopic dermatitis is not yet fully understood. To determine whether NGF
Norikazu Takano, Takanobu Sakurai, Michio Kurachi   +2 more
doaj   +1 more source

An investigation into the mechanisms by which bim gene expression is regulated in sympathetic neurons [PDF]

, 2010
Neuronal apoptosis plays a critical role in development and disease. Developing sympathetic neurons require nerve growth factor (NGF) for their survival and die by apoptosis in its absence.
Hughes, R.
core  

Comparative Analysis of Bioreactor Design and Scale‐Up for Cultivated Meat Using Monte Carlo‐Based Timescale Modeling

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Cultivated meat offers a sustainable alternative to conventional livestock production but faces significant scale‐up challenges, particularly in bioreactor design for mammalian cell suspension cultures. This study presents a comparative analysis of stirred tank reactors (STR), bubble columns (BC), and airlift reactors (ALR) to assess their ...
Pieter Jan Theodoor Brorens, Marcel Ottens, Cees Haringa   +2 more
wiley   +1 more source

Bioactivity comparison of NAT-NGF and LBD-NGF in vitro.

, 2013
(a) Effect of NAT-NGF and LBD-NGF on neurite outgrowth in PC12 cells. (b) Effect of NAT-NGF and LBD-NGF on cell survival in PC12 cells by MTT assay. (c) Percentage of PC12 cells with neurite outgrowth on laminin stimulated by NAT-NGF and LBD-NGF.
Qianqian Han (371914), Jingyu Wang (292122), Jianwu Dai (122949), Hui Zhao (7395), Wenjie Sun (164921), Zhifeng Xiao (371915), Hui Ma (290168), Bing Chen (32669), Changkai Sun (371912), Hang Lin (371913)   +9 more
core   +1 more source

NGF and therapeutic prospective: what have we learned from the NGF transgenic models? [PDF]

, 2015
It has been shown that topical nerve growth factor (NGF) administration induces healing action on human cutaneous, corneal and pressure ulcers, glaucoma, maculopathy and retinitis pigmentosa suggesting a therapeutic potential of NGF in human ...
Rocco, Maria Luisa, Maria Luisa Rocco, Luigi Aloe, Aloe, Luigi   +3 more
core   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Ulinastatin Promotes Regeneration of Peripheral Nerves After Sciatic Nerve Injury by Targeting let-7 microRNAs and Enhancing NGF Expression

Drug Design, Development and Therapy, 2020
Jincheng Zhang, Yingqi Zhang, Lei Chen, Zhitao Rao, Yeqing Sun Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, People’s Republic of ChinaCorrespondence: Yeqing SunDepartment of Orthopedics Tongji ...
Zhang J, Zhang Y, Chen L, Rao Z, Sun Y
doaj