Results 61 to 70 of about 94,176 (342)

Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]

Exploration of Drug Science
Proteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva, Polina Povarnina, Vladimir Dorofeev   +2 more
doaj   +1 more source

NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways

BioMed Research International, 2014
As a well-known neurotrophic factor, nerve growth factor (NGF) has also been extensively recognized for its acceleration of healing in cutaneous wounds in both animal models and randomized clinical trials.
Ji-Cai Chen, B. Lin, Hou-Wen Hu, Cai Lin, Wenxu Jin, Fa-Biao Zhang, Yan-An Zhu, Cai-jiao Lu, Xiaojie Wei, Rui-jie Chen   +9 more
semanticscholar   +1 more source

CONTROL OF LIPID METABOLISM BY NGF/P75NTR SIGNALINGS IN NEURON-GLIA NETWORK: NOVEL TARGETS FOR NEURODEGENERATIVE DISEASES

, 2022
Control of lipid metabolism by NGF/p75NTR signaling in neuron-glia network: novel targets for neurodegenerative diseases A prominent factor in cognitive abnormalities associated with various neurodegenerative diseases, including Alzheimer's Disease (AD ...
Viviana Triaca, Roberto Rizzi, Elena Fico, Nadia Canu, Marco Segatto, Georgios Strimpakos, Alvaro Crevenna   +6 more
core  

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF

Фармакокинетика и Фармакодинамика, 2016
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (
T. A. Antipova, I. O. Logvinov, S. V. Nikolaev, S. V. Kruglov, A. V. Tarasiuk, P. I. Antipov, T. A. Gudasheva, S. B. Seredenin   +7 more
doaj  

Incorporation of chitosan microspheres into collagen-chitosan scaffolds for the controlled release of nerve growth factor. [PDF]

PLoS ONE, 2014
Artifical nerve scaffold can be used as a promising alternative to autologous nerve grafts to enhance the repair of peripheral nerve defects. However, current nerve scaffolds lack efficient microstructure and neurotrophic support.Microsphere-Scaffold ...
Wen Zeng, Mengyao Rong, Xueyu Hu, Wei Xiao, Fengyu Qi, Jinghui Huang, Zhuojing Luo   +6 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

A Novel NGF Receptor Agonist B355252 Ameliorates Neuronal Loss and Inflammatory Responses in a Rat Model of Cerebral Ischemia

Journal of Inflammation Research, 2021
Hao-Kuang Wang,1,2 Jui-Sheng Chen,1,3,4 Chien-Yu Hsu,1 Yu-Ting Su,5 Tzu-Ching Sung,2 Cheng-Loong Liang,1,6 Aij-Lie Kwan,3,7 Cheng-Chun Wu6 1Department of Neurosurgery, E-DA Hospital, I-Shou University, Kaohsiung, Taiwan; 2School of Medicine for ...
Wang HK, Chen JS, Hsu CY, Su YT, Sung TC, Liang CL, Kwan AL, Wu CC   +7 more
doaj  

Neurotrophins induce fission of mitochondria along embryonic sensory axons

eLife, 2019
Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial
Lorena Armijo-Weingart, Andrea Ketschek, Rajiv Sainath, Almudena Pacheco, George M Smith, Gianluca Gallo   +5 more
doaj   +1 more source

Piezo‐Coupling Effects in Smart Polymers: Toward Ultrasensitive Sensing and Biomedical Applications

Advanced Science, EarlyView.
Piezo‐coupling effects are the foundational factors for the development of multifunctional and self‐powered platforms. Central to this advancement is the use of stimuli‐responsive smart polymers, which offer mechanical flexibility, biocompatibility, and simplified structural complexity with improved sensitivity and energy efficiency.
Duc Khanh Tran, Tuan Sang Tran, Thanh‐An Truong, Trung‐Hieu Vu, That Buu Ton, Dzung Viet Dao, Van Thanh Dau   +6 more
wiley   +1 more source