Results 131 to 140 of about 137,103 (391)
Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source
Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley +1 more source
Effects of Different Psychotropic Agents on the Central Nerve Growth [PDF]
Iranian Journal of Basic Medical Sciences, 2010 Psychotropic medications produce their effects, in part, through increasing neurotrophin levels in the brain. Since studies concerning nerve growth factor (NGF) analysis have been limited in scope, in the current experiments we investigated the effects ...
Parichehr Hassanzadeh, Anna Hassanzadeh
doaj
Nerve growth factor promotes survival of new neurons in the adult hippocampus
Neurobiology of Disease, 2007 Exogenously provided NGF enhances cognitive performance in impaired rodents and humans and is currently a promising compound for the treatment of dementia.
Helena Frielingsdorf +3 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray +8 more
wiley +1 more source
Identification and Functional Characterization of Novel and Recurrent NTRK1 Variants in Chinese Families With Congenital Insensitivity to Pain With Anhidrosis: A Combined Clinical, Genetic, and Functional Study. [PDF]
Eur J NeurolThis study investigates four Chinese families with congenital insensitivity to pain with anhidrosis (CIPA). Through next‐generation sequencing, we identified seven NTRK1 variants, including two novel mutations. Functional characterization of five identified missense and indel variants revealed distinct disruptions in the NGF‐TrkA pathway, ranging from ...
Ren Y +9 more
europepmc +2 more sources
Nerve growth factor (NGF) and its receptor TrkA —their relations with pain—
, 2020 Kazue Mizumura, Asako Kubo
openalex +2 more sources
, 1994 Summary In response to NGF, the Trk receptor tyrosine kinase forms a complex with SHC, a protein that couples receptor tyrosine kinases to p21 ras . Complex formation between Trk and SHC, SHC tyrosine phosphorylation, and association of SHC with Grb2 ...
R. Stephens +5 more
semanticscholar +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Introduction Maintenance of bladder filling and urinary storage at low intravesical pressures is fundamental to minimizing risk to the upper urinary tract. Bladder compliance describes the relationship between the bladder volume and the change in detrusor pressure during the filling phase of urodynamics.
Eric Rovner +5 more
wiley +1 more source