Results 71 to 80 of about 99,548 (294)
Advanced Science, EarlyView.Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang +4 more
wiley +1 more source
Coherent transmission through a one dimensional lattice [PDF]
Phys. Lett. A 331, 84 (2004), 2001 Based on the Keldysh nonequilibrium Green function (NGF) technique, a general formula for the current and transmission coefficient through a one dimensional lattice is derived without the consideration of electron-electron interactions. We obtain an analytical condition for perfect resonant transmission when the levels of sites are aligned, which ...
arxiv +1 more source
Advanced Science, EarlyView.The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang +8 more
wiley +1 more source
Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]
Exploration of Drug ScienceProteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva +2 more
doaj +1 more source
Dynamics of one-dimensional correlated nuclear systems within non-equilibrium Green's function theory [PDF]
, 2019 Theory of non-equilibrium Green's function (NGF) provides a practical framework for studying quantum many-body systems out of equilibrium. Extending the previous mean field approach developed for nuclear systems in one dimension with NGF, we introduce isospin degrees of freedom to the Green's functions and incorporate short-range two-body interactions ...
arxiv +1 more source
Electronic structure and transport for a laser-field-irradiated quantum wire with Rashba spin-orbit coupling [PDF]
Journal of Physics :Condensed Matter 18, 9161 (2006), 2006 We investigate theoretically the electronic structure and transport for a two-level quantum wire with Rashba spin-orbit coupling (SOC) under the irradiation of an external laser field at low temperatures. The photon-induced transitions between SOC-splitted subbands with the same lateral confinement quantum numbers and between subbands with different ...
arxiv +1 more source
Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles
Advanced Science, EarlyView.Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang +4 more
wiley +1 more source
Nerve growth factor nonresponsive pheochromocytoma cells: altered internalization results in signaling dysfunction. [PDF]
, 1992 Variant rat pheochromocytoma (PC12) cells which fail to respond to nerve growth factor (NGF) (PC12nnr5) (Green, S. H., R. E. Rydel, J. L. Connoly, and L. A. Greene. 1986. J. Cell Biol. 102:830-843) bind NGF at both high and low affinity sites.
Bradshaw, RA, Eveleth, DD
core
Efficient Backdoor Removal Through Natural Gradient Fine-tuning [PDF]
arXiv, 2023 The success of a deep neural network (DNN) heavily relies on the details of the training scheme; e.g., training data, architectures, hyper-parameters, etc. Recent backdoor attacks suggest that an adversary can take advantage of such training details and compromise the integrity of a DNN.
arxiv
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate, EarlyView.Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang +3 more
wiley +1 more source