Results 41 to 50 of about 48,088 (233)

Effect of Niacin on Growth Performance, Intestinal Morphology, Mucosal Immunity and Microbiota Composition in Weaned Piglets

Animals, 2021
Simple Summary The protective effect of niacin on growth performance and gut health of weaned piglets and the underlying mechanism remains unclear despite it being a common additive in pig diets.
Shilong Liu, Xiaoping Zhu, Y. Qiu, Li Wang, X. Shang, K. Gao, Xuefen Yang, Zong-yong Jiang   +7 more
semanticscholar   +1 more source

Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects

Arteriosclerosis, Thrombosis and Vascular Biology, 2021
Supplemental Digital Content is available in the text. Objective: Niacin therapy fails to reduce cardiovascular events in statin-treated subjects even though it increases plasma HDL-C (HDL [high-density lipoprotein] cholesterol) and decreases LDL-C (LDL [
G. Ronsein, T. Vaisar, W. Davidson, K. Bornfeldt, J. Probstfield, K. O’Brien, X. Zhao, J. Heinecke   +7 more
semanticscholar   +1 more source

EFFECT OF LOW-DOSE NIACIN ON DYSLIPIDEMIA, SERUM PHOSPHORUS LEVELS AND ADVERSE EFFECTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Kidney Research and Clinical Practice, 2012
Niacin supplementation improves dyslipidemia and lowers serum phosphorus levels in chronic kidney disease (CKD) patients. However, its adverse effects, including hot flusing, hinder the administration of niacin.
Won Suk An, Hyo Jin Kang, Ki Hyun Kim
doaj   +1 more source

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

Acta Neuropathologica, 2020
Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age. Both intrinsic changes in the oligodendrocyte progenitor cell population and extrinsic factors in the ...
Khalil S. Rawji, Adam M. H. Young, Tanay Ghosh, Nathan J. Michaels, R. Mirzaei, J. Kappen, Kathleen L. Kolehmainen, Nima Alaeiilkhchi, Brian M. Lozinski, M. Mishra, Annie Pu, Weiwen Tang, S. Zein, D. K. Kaushik, M.B. Keough, Jason R. Plemel, Fiona Calvert, Andrew J. Knights, Daniel J. Gaffney, W. Tetzlaff, R. Franklin, V. Yong   +21 more
semanticscholar   +1 more source

Network Pharmacology and bioinformatics analyses identify intersection genes of niacin and COVID-19 as potential therapeutic targets

Briefings Bioinform., 2020
Objectives Patients with colorectal cancer (CRC) may be susceptible to the coronavirus disease-2019 (COVID-19). However, anti-CRC/COVID-19 treatment options are currently unavailable.
Rong-chun Li, Yu Li, X. Liang, Lu Yang, M. Su, K. Lai   +5 more
semanticscholar   +1 more source

Niacin increases HDL biogenesis by enhancing DR4-dependent transcription of ABCA1 and lipidation of apolipoprotein A-I in HepG2 cells

Journal of Lipid Research, 2012
The lipidation of apoA-I in liver greatly influences HDL biogenesis and plasma HDL levels by stabilizing the secreted apoA-I. Niacin is the most effective lipid-regulating agent clinically available to raise HDL.
Lin-Hua Zhang, Vaijinath S. Kamanna, Shobha H. Ganji, Xi-Ming Xiong, Moti L. Kashyap   +4 more
doaj   +1 more source

Influence of niacin supplementation on the metabolic parameters and lipolysis in dairy cows during early lactation [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
The objective of this study was to evaluate the effect of niacin on the metabolic parameters and lipolysis inhibition in dairy cows during early lactation.
Talija HRISTOVSKA, Marko CINCOVIĆ, Dragica STOJANOVIĆ, Branislava BELIĆ, Zorana KOVAČEVIĆ, Milanka JEZDIMIROVIĆ   +5 more
doaj   +1 more source

The Role of Micronutrients in Atherosclerosis: Mechanisms and Clinical Application. [PDF]

J Cell Mol Med
ABSTRACT Micronutrients, though required in relatively small quantities by the human body, are essential for maintaining normal physiological functions and play a crucial role in the prevention and management of various diseases. Atherosclerosis (AS) is a common chronic inflammatory condition that often presents without obvious symptoms in its early ...
Ouyang Y, Jiang W, Long X, Mao P, He P, Ouyang X.   +5 more
europepmc   +2 more sources

Niacin inhibits surface expression of ATP synthase β chain in HepG2 cells: implications for raising HDL

Journal of Lipid Research, 2008
Niacin is an effective agent for raising HDL, but its cellular target sites are largely unknown. We examined effects of niacin on the surface expression of ATP synthase β chain, a newly described HDL/apolipoprotein A-I (apoA-I) receptor for HDL ...
Lin-Hua Zhang, Vaijinath S. Kamanna, Michael C. Zhang, Moti L. Kashyap   +3 more
doaj   +1 more source

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile[S]

Journal of Lipid Research, 2014
Prolonged niacin treatment elicits beneficial effects on the plasma lipid and lipoprotein profile that is associated with a protective CVD risk profile.
Mattijs M. Heemskerk, Harish K. Dharuri, Sjoerd A.A. van den Berg, Hulda S. Jónasdóttir, Dick-Paul Kloos, Martin Giera, Ko Willems van Dijk, Vanessa van Harmelen   +7 more
doaj   +1 more source