Results 111 to 120 of about 3,289 (188)

A novel nicastrin mutation in a three‐generation Dutch family with hidradenitis suppurativa: a search for functional significance [PDF]

, 2020
Allard R.J.V. Vossen, Kelsey R. van Straalen, Sigrid Swagemakers, Jan Klein, Andrew Stubbs, Deon J. Venter, Hessel H. van der Zee, Peter J. van der Spek, Errol P. Prens   +8 more
openalex   +1 more source

Genetic variations in extracellular matrix degradation pathways linking to major depressive disorder: Evidence from a large-scale genetic association study. [PDF]

Biomedicine (Taipei)
Zailani H, Chen DT, Lin SC, Lee JH, Li ML, Chang JP, Su KP.   +6 more
europepmc   +1 more source

The Binding of Different Substrate Molecules at the Docking Site and the Active Site of γ-Secretase Can Trigger Toxic Events in Sporadic and Familial Alzheimer's Disease. [PDF]

Int J Mol Sci, 2023
Svedružić ŽM, Šendula Jengić V, Ostojić L.   +2 more
europepmc   +1 more source

γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo [PDF]

, 2007
Laura Doglio, Ritu Kanwar, George R. Jackson, Mar Pérez, Jesús Ávila, Colin Dingwall, Carlos G. Dotti, Mark Fortini, Fabián Feiguin   +8 more
openalex   +1 more source

Androgenic hidradenitis suppurativa onset linked to gamma secretase inhibitor. [PDF]

JAAD Case Rep
Tai H, Hill KT, Parvathaneni A, Islam Z, Cohen SR.   +4 more
europepmc   +1 more source

Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity [PDF]

, 2009
Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Noriko Isoo, Satoko Osawa, Maiko A. Fukuda, Tatsuhiko Kodama, Takao Hamakubo, Tong Li, Philip C. Wong, Taisuke Tomita, Takeshi Iwatsubo   +12 more
openalex   +1 more source

The role of γ-secretase in familial hidradenitis suppurativa: Implications for pathogenesis and targeted therapy. [PDF]

JAAD Case Rep
Desta B, Korytnikova E, Tessier-Kay M, Klufas T, Lu J, Sarfo A, Zhou AE.   +6 more
europepmc   +1 more source

Use of an Intramolecular Quenched Fluorescence (IQF) Cleavage Assay for Assessing Enzyme Kinetics of Gamma-Secretase in Human Skin Fibroblasts and Keratinocytes. [PDF]

Methods Mol Biol
Badiei B, Garza LA.
europepmc   +1 more source

Nicastrin expression in mouse peripheral tissues is not co‐ordinated with presenilin and is high in muscle [PDF]

, 2004
Nancy T. Ilaya, Geneviève Evin, Colin L. Masters, Janetta G. Culvenor   +3 more
openalex   +1 more source

Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme-Substrate Complex Formation. [PDF]

Biomolecules
Devkota S, Maesako M, Wolfe MS.
europepmc   +1 more source