Results 11 to 20 of about 3,289 (188)

Serum Immunoglobulin G Levels and Nicastrin Variation in Hidradenitis Suppurativa.

JAMA Dermatol
ImportanceVariation in nicastrin (NCSTN) is associated with a monogenic subtype of hidradenitis suppurativa. Dysregulation of humoral immunity has been suggested as a potential mechanistic link between NCSTN variation and hidradenitis suppurativa. There is a paucity of biomarkers that can predict disease-associated variation.ObjectiveTo investigate ...
Mintoff D, Pace NP.
europepmc   +5 more sources

The Notch inhibitor cowanin accelerates nicastrin degradation [PDF]

Scientific Reports, 2018
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential.
Midori A. Arai, Ryuta Akamine, Anna Tsuchiya, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi   +6 more
doaj   +3 more sources

Nicastrin [PDF]

, 2020
National Cancer Institute
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Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.

PLoS ONE, 2012
The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor.
Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong, Mi-Yeon Kim, Eun-Jung Ann, Ji-Seon Ahn, Su-Man Kim, Hyeong-Jin Baek, Florian Lang, Eui-Ju Choi, Hee-Sae Park   +10 more
doaj   +3 more sources

Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease [PDF]

Nature Communications
Hidradenitis Suppurativa (HS) is an inflammatory skin disorder with limited treatments and unclear etiology. While monogenic HS is linked to gamma secretase mutations, particularly in the NCSTN subunit, the pathogenesis of the more common sporadic form ...
Kaitlin L. Williams, Beita Badiei, James Reilly, William Andrews, Hana B. Minsky, Nina Rossa Haddad, Eddie G. Martinez Pena, Mengqi Sun, Sam Lee, Ang Li, Leigh Curvin-Aquilla, Arieana Y. Johnson, Aiden Willis, Charles S. Kirby, Amy van Ee, Yingchao Xue, Carrie A. Cox, Shanmuga Priya Rajagopalan, Sewon Kang, Kurunthachalam Kannan, Julie Caffrey, Nathan K. Archer, Maureen Kane, Luis A. Garza   +23 more
doaj   +2 more sources

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease [PDF]

Frontiers in Aging Neuroscience
The intramembrane aspartic protease, γ-secretase, is a heterotetrameric protein complex composed of four integral membrane proteins: presenilin (PSEN), nicastrin (NCT), Anterior pharynx defective-1 (APH-1), and presenilin enhancer 2 (PEN-2).
Gao Ning, Gao Ning, Xing Fan, Du Juan, Du Juan, Zhao wenxue, Wang Sijia, Chen Meinei, Chen Meinei, Dong Xiaolong, Qi Yiming   +10 more
doaj   +2 more sources

Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. [PDF]

Genetics
Brinkley DM, Smith KC, Fink EC, Kwen W, Yoo NH, West Z, Sullivan NL, Farthing AS, Hale VA, Goutte C.   +9 more
europepmc   +3 more sources

γ-Secretase; nicastrin (NCSTN) [PDF]

Science-Business eXchange, 2009

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P3‐336: Purification and cocrystallization of nicastrin ectodomain [PDF]

Alzheimer's & Dementia, 2008
Alzheimer's & Dementia: The Journal of the Alzheimer's Association 4 (2008) T620-T620.
Guoqing Lin, Seonghun Kim, Brenda Leung, Akiko Koide, Shohei Koide, Sangram S. Sisodia   +5 more
openalex   +3 more sources

Nicastrin Functions as a γ-Secretase-Substrate Receptor [PDF]

Cell, 2005
gamma-secretase catalyzes the intramembrane cleavage of amyloid precursor protein (APP) and Notch after their extracellular domains are shed by site-specific proteolysis. Nicastrin is an essential glycoprotein component of the gamma-secretase complex but has no known function.
Sanjiv Shah, Sheu-Fen Lee, Katsuhiko Tabuchi, Yi-Heng Hao, Cong Yu, Quincey LaPlant, Haydn L. Ball, Charles E. Dann, Thomas C. Südhof, Gang Yu   +9 more
openalex   +3 more sources