Results 21 to 30 of about 3,289 (188)

Novel variant of the NCSTN gene identified in a woman with hidradenitis suppurativa. [PDF]

J Dtsch Dermatol Ges
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 10, Page 1332-1334, October 2025.
Hempel C, Grunewald S, Mittank-Weidner T, Simon JC, Schnabel F, Jauss RT, Schnabel V.   +6 more
europepmc   +2 more sources

Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation. [PDF]

Adv Sci (Weinh)
This study identifies Membralin as an ER‐phagy receptor that recruits MAN1B1 and VCP to form a selective ERLAD complex. By sensing dense N‐glycan clusters on viral fusion glycoproteins, this ubiquitin‐independent pathway directs SARS‐CoV‐2 spike, Ebola GP, influenza HA, and HIV‐1 Env to lysosomal degradation, thereby limiting viral infectivity ...
Zhang J, Lu X, Li S, Wang T, Ahmad I, Zheng YH.   +5 more
europepmc   +2 more sources

Cellular localization of Nicastrin affects amyloid β species production [PDF]

FEBS Letters, 2008
The γ‐secretase complex, composed by presenilin, nicastrin, APH‐1 and PEN‐2, is involved in intramembranous proteolysis of membrane proteins, such as amyloid precursor protein or Notch. Cleavage occurs in multiple cellular compartments. Here, nicastrin mutants containing targeting signals to the endoplasmic reticulum, trans‐Golgi network, lysosomes, or
Vanessa A. Morais, Susan Leight, Donald S. Pijak, Virginia M.‐Y. Lee, Júlia Costa   +4 more
openalex   +3 more sources

Dexamethasone does not ameliorate gliosis in a mouse model of neurodegenerative disease

Biochemistry and Biophysics Reports, 2020
Prolonged neuroinflammation is a driving force for neurodegenerative disease, and agents against inflammatory responses are regarded as potential treatment strategies. Here we aimed to evaluate the prevention effects on gliosis by dexamethasone (DEX), an
Xiaolian Ye, Gang Zou, Jinxing Hou, Huiru Bi, Cuihua Zhou, Runmin Wang, Yun Xu, Chun Wang, Guiquan Chen, Zhenyu Yin, Jinping Zhang, Chaoli Huang   +11 more
doaj   +1 more source

Interpreting the spectrum of gamma-secretase complex missense variation in the context of hidradenitis suppurativa—An in-silico study

Frontiers in Genetics, 2022
Hidradenitis suppurativa (HS) is a disease of the pilosebaceous unit characterized by recurrent nodules, abscesses and draining tunnels with a predilection to intertriginous skin. The pathophysiology of HS is complex.
Dillon Mintoff, Dillon Mintoff, Nikolai P. Pace, Nikolai P. Pace, Isabella Borg, Isabella Borg, Isabella Borg   +6 more
doaj   +1 more source

Akt1 phosphorylates Nicastrin to regulate its protein stability and activity [PDF]

Journal of Neurochemistry, 2015
AbstractThe gamma‐secretase is a multiprotein complex that cleaves many type‐I membrane proteins, such as the Notch receptor and the amyloid precursor protein. Nicastrin (NCT) is an essential component of the multimeric gamma‐secretase complex and functions as a receptor for gamma‐secretase substrates.
Eunhye Jo, Ji‐Seon Ahn, Jung‐Soon Mo, Ji‐Hye Yoon, Eun‐Jung Ann, Hyeong‐Jin Baek, Hyejin Lee, Seol‐Hee Kim, Mi‐Yeon Kim, Hee‐Sae Park   +9 more
openalex   +3 more sources

The Nicastrin ectodomain adopts a highly thermostable structure [PDF]

bchm, 2011
Abstract Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight γ-secretase complex. γ-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid β-peptide. Four proteins Nicastrin, anterior pharynx-defective-1 (Aph-1)
Fluhrer, Regina, Kamp, Frits, Grammer, Gudula, Nuscher, Brigitte, Steiner, Harald, Beyer, Klaus, Haass, Christian   +6 more
openaire   +4 more sources

Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa

HGG Advances, 2023
Summary: Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease for which few treatment options are available. While most HS is sporadic, some rare kindred show a high-penetrance, autosomal-dominant inheritance.
David J. Morales-Heil, Li Cao, Cheryl Sweeney, Anna Malara, Frank Brown, Philip Milam, Milan Anadkat, Jessica Kaffenberger, Benjamin Kaffenberger, Peter Nagele, Brian Kirby, Elisha D.O. Roberson   +11 more
doaj   +1 more source

Synaptic function of nicastrin in hippocampal neurons [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Mutations in the presenilin genes are the major cause of familial forms of Alzheimer’s disease. Nicastrin and presenilin are essential components of the γ-secretase complex, an intramembrane protease that cleaves type I membrane proteins such as Notch and the amyloid precursor protein ...
Sang Hun, Lee, Manu, Sharma, Thomas C, Südhof, Jie, Shen   +3 more
openaire   +2 more sources

Celastrol and Triptolide Suppress Stemness in Triple Negative Breast Cancer: Notch as a Therapeutic Target for Stem Cells

Biomedicines, 2021
Triple negative breast cancer (TNBC) is observed in ~15% of breast cancers and results in poor survival and increased distant metastases. Within the tumor are present a small portion of cancer stem cells that drive tumorigenesis and metastasis.
Prabhu Ramamoorthy, Prasad Dandawate, Roy A. Jensen, Shrikant Anant   +3 more
doaj   +1 more source