Results 61 to 70 of about 3,289 (188)
Protein O‐GlcNAcylation in Health and Diseases
MedComm, Volume 6, Issue 12, December 2025.We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran +5 more
wiley +1 more source
Molecular Neurodegeneration, 2012 Background The 5-lipoxygenase (5LO) enzymatic pathway is widely distributed within the central nervous system. Previous works showed that this protein is up-regulated in Alzheimer's disease (AD), and that its genetic absence results in a reduction of ...
Chu Jin +4 more
doaj +1 more source
From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae
Yeast, Volume 42, Issue 12, Page 283-302, December 2025.Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior +2 more
wiley +1 more source
eLife, 2020 γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data.
Abril Angélica Escamilla-Ayala +12 more
doaj +1 more source
Aging Cell, Volume 24, Issue 11, November 2025.Targeting muscle with Cathepsin B (Ctsb) to treat the AD mouse brain. In this study, an AAV‐vector‐mediated approach, utilized to express Ctsb in muscle, prevented mnemonic and neurogenic deficits and normalized hippocampal, muscle, and plasma proteomic profiles.
Alejandro Pinto +16 more
wiley +1 more source
The FASEB Journal, Volume 39, Issue 20, 31 October 2025.Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu +5 more
wiley +1 more source
Γ-secretase components as predictors of breast cancer outcome.
PLoS ONE, 2013 γ-secretase is a large ubiquitously expressed protease complex composed of four core subunits: presenilin, Aph1, PEN-2, and nicastrin. The function of γ-secretase in the cells is to proteolytically cleave various proteins within their transmembrane ...
Hanna M Peltonen +5 more
doaj +1 more source
Molecular Neurodegeneration, 2020 The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in ...
Annie Y. Yao, Riqiang Yan
doaj +1 more source
Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease. [PDF]
PLoS ONE, 2013 Composed of Ginsenoside Rg1 and Geniposide, the herbal medicine TongLuoJiuNao (TLJN) injection liquid has anti-inflammatory properties and can improve learning and memory in mice.
Ping He +6 more
doaj +1 more source
Notch Cleavage: Nicastrin Helps Presenilin Make the Final Cut [PDF]
Current Biology, 2002 Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.
openaire +2 more sources