Results 81 to 90 of about 3,289 (188)

Autophagy and Cellular Senescence in Alzheimer's Disease: Key Drivers of Neurodegeneration

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
Impaired autophagy in Alzheimer's disease leads to accumulation of amyloid‐β and tau aggregates, while senescent brain cells secrete pro‐inflammatory SASP factors. The interplay between defective clearance and chronic inflammation accelerates neuronal dysfunction and highlights autophagy enhancers and senolytics as promising therapeutic strategies ...
Md Sadique Hussain, Neetu Agrawal, Baby Ilma, Rekha M M, Priya Priyadarshini Nayak, Mandeep Kaur, Anil Khachi, Kavita Goyal, Arcot Rekha, Saurabh Gupta, Gaurav Gupta, Kamal Dua   +11 more
wiley   +1 more source

Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates

Neurobiology of Disease, 2003
γ-Secretase is a proteolytic complex whose substrates include Notch, β-amyloid precursor protein (APP), and several other type I transmembrane proteins. Presenilin (PS) and nicastrin are known components of this high-molecular-weight complex, and recent ...
Stephanie Baulac, Matthew J LaVoie, W.Taylor Kimberly, Jennifer Strahle, Michael S Wolfe, Dennis J Selkoe, Weiming Xia   +6 more
doaj   +1 more source

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, Volume 11, Issue 2, Page 162-184, Summer 2025.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Maintaining the Integral Membrane Proteome: Revisiting the Functional Repertoire of Integral Membrane Proteases

ChemBioChem, Volume 26, Issue 9, May 5, 2025.
Regulated intramembrane proteolysis is crucial for functional proteome in all kingdoms of life. The task of cleaving transmembrane proteins within the unique environment of the lipid bilayer presents biochemical challenges that has been solved by integral membrane proteases (IMPRs).
Hannah Fremlén, Björn M. Burmann
wiley   +1 more source

Targeting SHMT2‐mediated membrane phospholipid remodeling for enhanced anti‐GCSCs treatment

Interdisciplinary Medicine, Volume 3, Issue 3, May 2025.
Depletion of serine via serine hydroxymethyltransferase‐2 (SHMT2) knockdown in gastric cancer (GC) disrupted the maintenance of gastric cancer stem cell stemness by inducing membrane phospholipid remodeling and aberrant CD44 shedding within membrane lipid rafts. The synthesized HA‐Exo‐si SHMT2 demonstrated enhanced therapeutic efficacy and safety in GC.
Liping Yang, Fangli Liao, Yanran Tong, Tong Huang, Yan‐e Du, Siyang Wen, Linshan Jiang, Lanlang Peng, Hua Sun, Gaoli Zhang, Weixian Chen   +10 more
wiley   +1 more source

Pathological activity of familial Alzheimer’s disease-associated mutant presenilin can be executed by six different γ-secretase complexes

Neurobiology of Disease, 2007
γ-Secretase is a protease complex, which catalyzes the final of two subsequent cleavages of the β-amyloid precursor protein (APP) to release the amyloid-β peptide (Aβ) implicated in Alzheimer’s disease (AD) pathogenesis.
Keiro Shirotani, Masanori Tomioka, Elisabeth Kremmer, Christian Haass, Harald Steiner   +4 more
doaj   +1 more source

Oxidative stress and lipid peroxidation are upstream of amyloid pathology

Neurobiology of Disease, 2015
Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the direct causative relationship between oxidative stress and amyloid pathology, and determining the ...
Muriel Arimon, Shuko Takeda, Kathryn L. Post, Sarah Svirsky, Bradley T. Hyman, Oksana Berezovska   +5 more
doaj   +1 more source

Aph-2/Nicastrin [PDF]

Neuron, 2002
Kopan, Raphael, Goate, Alison
openaire   +1 more source

Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease

Molecular Therapy: Nucleic Acids, 2015
Alzheimer's disease (AD) is a multifactorial, fatal neurodegenerative disorder characterized by the abnormal accumulation of Aβ and Tau deposits in the brain.
Sepideh Parsi, Pascal Y Smith, Claudia Goupil, Véronique Dorval, Sébastien S Hébert   +4 more
doaj   +1 more source

OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin [PDF]

, 2013
Jonghee Han, Sunmin Jung, Jiyeon Jang, Tae‐In Kam, Hyunwoo Choi, Byung-Ju Kim, Jihoon Nah, Dong‐Gyu Jo, Toshiyuki Nakagawa, Masaki Nishimura, Yong‐Keun Jung   +10 more
openalex   +1 more source