Results 1 to 10 of about 4,650 (177)

S100A4 Orchestrates Fibroblast Fate to Drive Fibrotic Remodeling. [PDF]

FASEB J
Fibrotic stimuli induce S100A4 expression, promoting the activation of apoptosis‐resistant fibroblasts through engagement of ERK‐associated signaling. In fibroblasts, S100A4 orchestrates fibroblast fate by enhancing migration, promoting stress fiber formation, increasing ECM contractility, upregulating α‐SMA expression, and supporting survival ...
Li S, Cai B, Zhang X, Cai G, Zhou Y, Wagener BM, Ding Q.   +6 more
europepmc   +2 more sources

The magic bullet: Niclosamide

Frontiers in Oncology, 2022
The term ‘magic bullet’ is a scientific concept proposed by the German Nobel laureate Paul Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease without harming the body. Oncologists have been looking for a magic
Haowen Jiang, Albert M. Li, Albert M. Li, Jiangbin Ye, Jiangbin Ye, Jiangbin Ye   +5 more
doaj   +3 more sources

The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. [PDF]

Arthritis Rheumatol
Objective Ear, nose, and throat (ENT) manifestations are common in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). There is an unmet need for drugs to target these manifestations. Granuloma formation is characteristic of proteinase 3 (PR3)–AAV. In a zebrafish model, niclosamide inhibits PR3‐induced granuloma formation.
Lim B, Qian W, Dowling F, Salama A, Smith RM.   +4 more
europepmc   +2 more sources

New life for an old drug: In vitro and in vivo effects of the anthelmintic drug niclosamide against Toxoplasma gondii RH strain

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Toxoplasma gondii is the causative agent of toxoplasmosis and causes serious public health problems. However, the current treatment drugs have many limitations, such as serious side effects.
Bing Li
exaly   +3 more sources

Chronic Exposure to Niclosamide Disrupts Structure and Metabolism of Digestive Glands and Foot in Cipangopaludina cathayensis [PDF]

Biology
Niclosamide has been the primary molluscicide for schistosomiasis control for over 50 years, but its chronic effects on inter-organ interactions in non-target mollusks remain poorly understood.
Yanan Zhang, Yizhen Liu, Qiying Cai, Jun Ye, Tao Wang, Sheng Xu, Gang Ge   +6 more
doaj   +2 more sources

Niclosamide attenuates skin cancer progression through suppression of key oncogenic pathways: integrated in vivo and in-silico mechanistic insights [PDF]

BMC Cancer
Niclosamide, an FDA-approved anti-helminthic drug, has attracted attention for its potential to target multiple cancer-related pathways. This study evaluated the chemopreventive effect of niclosamide in a DMBA/TPA-induced mouse model of skin ...
Amjad Ibrahim Oraibi, Mahmood Al-Ibadah, Ali Al-Samydai, Muataz Naeem Hussein, Hany Akeel Al-hussaniy, Maryam Saleem, Ali Almukram, Mulugeta Tesemma, Esmael M. Alyami, Ohoud A. Alghamdi, Ahmed Hamza Al-Shammari, Gehan M. Elossaily, Omar A. Almohammed   +12 more
doaj   +2 more sources

Niclosamide methanol solvate and niclosamide hydrate: structure, solvent inclusion mode and implications for properties [PDF]

Acta Crystallographica Section C, Structural Chemistry, 2014
Structural studies have been carried out of two solid forms of niclosamide [5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, NCL], a widely used anthelmintic drug, namely niclosamide methanol monosolvate, C13H8Cl2N2O4·CH3OH or NCL·MeOH, and niclosamide monohydrate, denoted HA.
Claire Wilson, Ivana Radosavljevic Evans, Wilson C   +2 more
exaly   +4 more sources

Niclosamide: Beyond an antihelminthic drug

Cellular Signalling, 2018
Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites.
Jiangbo Wang, Wei Chen, Richard T Premont   +2 more
exaly   +3 more sources

Electro-Stimulated Graphene-Polymer Nanocomposites Enable Wearable Patches With Feedback-Controlled Drug Release. [PDF]

Adv Healthc Mater
xx xx. ABSTRACT Stimuli‐responsive nanomaterials capable of spatiotemporal control over drug release are of nanocomposite patch (“e‐Medi‐Patch”) engineered from biodegradable polycaprolactone (PCL), graphene nanoplatelets, and a redox‐active therapeutic, niclosamide. The hierarchical composite integrates π‐π interactions between aromatic drug molecules
Misra SK, Dighe K, Saha P, Aditya T, Khan MS, Alafeef M, Moitra P, Pan D.   +7 more
europepmc   +2 more sources

Niclosamide Modulates the Cellular and Humoral Immune Response in Balb/c Mice [PDF]

Iranian Journal of Immunology, 2022
Background: Niclosamide, a STAT3 inhibitor, is widely under investigation due to its anti-cancer properties. STAT3 also exhibits an exciting role in the immune responses.
Bilal Mahmood Beg, Aqeel Javeed, Muhammad Ashraf, Arfan Ahmad, Adeel Sattar, Mehmood Ahmad   +5 more
doaj   +1 more source