Results 21 to 30 of about 4,650 (177)
PLoS ONE, 2021 SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development.
Anne Weiss +7 more
doaj +1 more source
Niclosamide for Covid-19: bridging the gap [PDF]
Molecular Biology Reports, 2021 Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL modulates of uncoupling oxidative phosphorylation and different signaling pathways in human biological processes.
Hayder M. Al-kuraishy +4 more
openaire +2 more sources
Molecules, 2018 Niclosamide is used to treat intestinal parasite infections, as being an anthelmintic drug. Recently, several papers suggest the niclosamide inhibits multiple signaling pathways, which are highly activated and mutated in cancer.
Jeong Mi Yun +5 more
doaj +1 more source
Scientific Reports, 2021 Niclosamide has preclinical activity against a wide range of cancers. In prostate cancer, it inhibits androgen receptor variant 7 and synergizes with abiraterone. The approved niclosamide formulation has poor oral bioavailability.
Mamta Parikh +9 more
doaj +1 more source
Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition
Heliyon, 2020 Niclosamide has been known to inhibit a number of pH-dependent viruses via the neutralization of endosomal acidic pH. It has also been shown to disrupt the mTORC1 signaling pathway. The replication of many viruses requires mTORC1 activation.
Nattamon Niyomdecha +4 more
doaj +1 more source
Ecotoxicology and Environmental Safety, 2022 Since the 1960s, invasive sea lamprey (Petromyzon marinus) populations in the Laurentian Great Lakes have been controlled by applying two chemicals, 3-trifluoromethyl-4-nitrophenol (TFM) and 2’,5-dichloro-4’-nitrosalicylanilide (niclosamide, aka ...
R. Adrian Ionescu +2 more
doaj +1 more source
Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice
Journal of Plant Protection Research, 2016 Bacterial leaf blight is one of the major diseases in rice and affects yields. Thus, various methods have been applied to protect rice from this disease.
Kim Sung-Il +3 more
doaj +1 more source
Niclosamide as a Repurposing Drug against Corynebacterium striatum Multidrug-Resistant Infections
Antibiotics, 2022 Corynebacterium striatum (C. striatum) is an emerging multidrug-resistant (MDR) pathogen associated with nosocomial infections. In this scenario, we screened the antimicrobial activity of the anthelmintic drugs doramectin, moxidectin, selamectin and ...
Veronica Folliero +10 more
doaj +1 more source
Presumed veterinary niclosamide-induced retinal toxicity in a human: a case report
Journal of Medical Case Reports, 2023 Background To report the first case of bull’s eye maculopathy associated with veterinary niclosamide. Case presentation A 27-year-old Iranian female presented with a history of reduced vision and photopsia since 3 years, after accidental ingestion of ...
Fatemeh Bazvand +2 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Niclosamide is a traditional anti-tapeworm drug that exhibits potent anti-cancer activity. Our previous study showed that niclosamide induces cell cycle arrest in G1 phase. Nevertheless, the underlying mechanism remains unknown.
Zewen Han +7 more
doaj +1 more source