Results 41 to 50 of about 8,705 (221)

Niclosamide—A promising treatment for COVID‐19

British Journal of Pharmacology, 2022
Vaccines have reduced the transmission and severity of COVID‐19, but there remains a paucity of efficacious treatment for drug‐resistant strains and more susceptible individuals, particularly those who mount a suboptimal vaccine response, either due to underlying health conditions or concomitant therapies.
Shivani Singh, Anne Weiss, James Goodman, Marie Fisk, Spoorthy Kulkarni, Ing Lu, Joanna Gray, Rona Smith, Morten Sommer, Joseph Cheriyan   +9 more
openaire   +3 more sources

Effects of Bayluscide WP 70® on the Survival and Water-leaving Behaviour of Biomphalaria straminea, Snail Host of Schistosomiasis in Northeast Brazil [PDF]

Memorias do Instituto Oswaldo Cruz, 1997
The toxic and behavioural effects of niclosamide (Bayluscide WP 70®) on Biomphalaria straminea from a highly endemic area of schistosomiasis in northeastern Brazil were investigated through laboratory bioassays.
Otília Sarquis, Otávio S Pieri, José Augusto A dos Santos   +2 more
doaj   +1 more source

Pseudopolymorphic transitions of niclosamide monitored by Raman spectroscopy [PDF]

, 2008
Niclosamide suffers pseudopolymorphic transformations when exposed to different ambient conditions, which can lead to changes in its bioavailability.
Amado, Bauer, Becke, Brittain, Brown, Bugay, Burger, Caira, Caira, Colthup, Davis, de Villiers, Dunitz, Fini, Frisch, Gamberini, Giordano, Girling, Giron, Haleblian, Hariharan, Hausman, Johansson, Jørgensen, Khankari, Khawam, Lee, Manek, Marigheto, Nolasco, O'Brien, Ortega, Phadnis, Pratiwi, Rodríguez-Spong, Scott, Stahl, Starbuck, Sun, Szelagiewicz, van Tonder, Vyazovkin, Yu   +42 more
core   +1 more source

Structure–Activity Relationship of Niclosamide Derivatives [PDF]

Anticancer Research, 2017
Cancer is a leading cause of death. Hence, this study aimed at the optimization of niclosamide derivatives for the development of new potential anticancer agents.Niclosamide derivatives were synthesized and tested against a panel of human cancer cells: MDA and MCF7 breast cancer cells, PC3 and DU-145 prostate cancer cells, Hela cervical cancer cells ...
Zhonghai, Tang, Ulyana Muñoz, Acuña, Nelson Freitas, Fernandes, Somsundaram, Chettiar, Pui-Kai, Li, Esperanza Carcache, DE Blanco   +5 more
openaire   +2 more sources

Niclosamide potentiates TMEM16A and induces vasoconstriction

Biophysical Journal, 2023
ABSTRACTThe TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but was recently found to possess broad-spectrum off-target effects.
Pengfei Liang, Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang   +4 more
openaire   +3 more sources

Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis

Frontiers in Pharmacology, 2019
Niclosamide is a traditional anti-tapeworm drug that exhibits potent anti-cancer activity. Our previous study showed that niclosamide induces cell cycle arrest in G1 phase. Nevertheless, the underlying mechanism remains unknown.
Zewen Han, Qingxiang Li, Yifei Wang, Lin Wang, Xiaoxu Li, Na Ge, Yixiang Wang, Chuanbin Guo   +7 more
doaj   +1 more source

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources

Cysticercosis and taeniasis cases diagnosed at two referral medical institutions, Belgium, 1990 to 2015 [PDF]

, 2019
Background: Few case reports on human infections with the beef tapeworm Taenia saginata and the pork tapeworm, Taenia solium, diagnosed in Belgium have been published, yet the grey literature suggests a higher number of cases.
Bottieau, Emmanuel, Dermauw, Veronique, Dorny, Pierre, Luyckx, Kim, Luyten, Leon, Van Bockstal, Lieselotte, Van Den Broucke, Steven   +6 more
core   +1 more source

Niclosamide Attenuates Inflammation-Associated Profibrotic Responses in Human Subepithelial Lung Myofibroblasts

Biomedicines, 2023
Niclosamide is a commonly used helminthicidic drug for the treatment of human parasitosis by helminths. Recently, efforts have been focusing on repurposing this drug for the treatment of other diseases, such as idiopathic pulmonary fibrosis ...
Michail Spathakis, Gesthimani Tarapatzi, Eirini Filidou, Leonidas Kandilogiannakis, Evangelos Karatzas, Paschalis Steiropoulos, Dimitrios Mikroulis, George M. Spyrou, Vangelis G. Manolopoulos, George Kolios, Konstantinos Arvanitidis   +10 more
doaj   +1 more source

Interrupting seasonal transmission of Schistosoma haematobium and control of soil-transmitted helminthiasis in northern and central Côte d’Ivoire: a SCORE study protocol [PDF]

, 2018
© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in ...
Allan, F, Coulibaly, JT, Diakite, NR, Hurlimann, E, Knopp, S, Konan, CK, Meite, A, N'Goran, EK, Ouattara, M, Rollinson, D, Tian-Bi, Y-NT, Utzinger, J, Webster, BL   +12 more
core   +3 more sources