Results 41 to 50 of about 4,650 (177)

Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study

Pharmaceutics, 2021
We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule niclosamide that achieved a more than two-fold increase in bioavailability.
Miguel O. Jara, Zachary N. Warnken, Robert O. Williams   +2 more
doaj   +1 more source

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

mBio, 2020
One avenue to combat multidrug-resistant Gram-negative bacteria is the coadministration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize.
Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden, Charlotte M. Miton, Rebecca J. Edgar, Michelle H. Rich, Rory F. Little, Elsie M. Williams, Robert E. W. Hancock, Nobuhiko Tokuriki, David F. Ackerley   +11 more
doaj   +1 more source

Synthesis and biological evaluation of niclosamide PROTACs

Bioorganic & Medicinal Chemistry Letters, 2022
Roughly 268,000 new cases of prostate cancer and 34,000 deaths from prostate cancer are projected by the American Cancer Society to occur in the United States in 2022. Androgen receptor is a key protein in the proliferation and survival of prostate cancer cells and has been revealed to be overexpressed in 30% to 50% of castration-resistant prostate ...
Munoz, Erick, Chen, Guanglin, Hossain, Ahamed, Wu, Sitong, Nava, Esveidy Oceguera, Hang, Jasmine, Lee, Tong, Zhang, Qiang, Wang, Guangdi, Chen, Qiao-Hong   +9 more
openaire   +2 more sources

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2018
Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates. However, in the last few years, colistin-resistant A. baumannii and K.
Rafael Ayerbe-Algaba, María Luisa Gil-Marqués, Manuel Enrique Jiménez-Mejías, Viviana Sánchez-Encinales, Raquel Parra-Millán, María Eugenia Pachón-Ibáñez, Jerónimo Pachón, Jerónimo Pachón, Younes Smani   +8 more
doaj   +1 more source

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in Pharmacology, 2022
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.
John Villandre, John Villandre, Virginia White, Travis B. Lear, Travis B. Lear, Yanwen Chen, Ferhan Tuncer, Emily Vaiz, Beyza Tuncer, Karina Lockwood, Dan Camarco, Yuan Liu, Yuan Liu, Yuan Liu, Bill B. Chen, Bill B. Chen, Bill B. Chen, John Evankovich, John Evankovich   +18 more
doaj   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Niclosamide potentiates TMEM16A and induces vasoconstriction

Biophysical Journal, 2023
ABSTRACT The TMEM16A calcium-activated chloride channel is a promising therapeutic target for various diseases. Niclosamide, an anthelmintic medication, has been considered as a TMEM16A inhibitor for treating asthma and chronic obstructive pulmonary disease, but was recently found to possess broad-spectrum off-target effects.
Pengfei Liang, Yui Chun S. Wan, Kuai Yu, H. Criss Hartzell, Huanghe Yang   +4 more
openaire   +3 more sources

Identification of Novel Therapeutic Agent Candidates Through High Throughput Screening With Chemical Library Based on Molecular Subclassification in Canine Histiocytic Sarcoma Cell Lines

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.
ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma, Hirotaka Tomiyasu, Mari Takamiya, Yuko Goto‐Koshino, Atsushi Tsukamoto, Makoto Bonkobara, Masaru Okuda   +6 more
wiley   +1 more source

New polymeric molluscicide-attractant (niclosamide-l-glutamate) for control of Biomphalaria alexandrina

Egyptian Journal of Aquatic Research, 2020
Controlled-release technology was introduced to offer an incredible guarantee for improving the adequacy of the existing active molecules and solving the related environmental troubles.
El-Refaie Kenawy, Samar F. Harras, El-Sayed T. Rizk, Mohamed H. Mona, Mostafa H. ElMehlawy   +4 more
doaj   +1 more source