Results 51 to 60 of about 8,705 (221)
Desolvation Processes in Channel Solvates of Niclosamide
Molecular Pharmaceutics, 2023 The antiparasitic drug niclosamide (NCL) is notable for its ability to crystallize in multiple 1:1 channel solvate forms, none of which are isostructural. Here, using a combination of time-resolved synchrotron powder X-ray diffraction and thermogravimetry, the process-induced desolvation mechanisms of methanol and acetonitrile solvates are investigated.
Jen E. Mann +3 more
openaire +2 more sources
Cancer Medicine, 2018 The incidence and mortality rate of urological cancers is increasing yearly. Niclosamide has been repurposed as an anti‐cancer drug in recent years. Synthesized derivative of niclosamide was testified for its anti‐cancer activity in urological cancers ...
Chia‐Lun Wu +3 more
doaj +1 more source
Drug repositioning : a machine-learning approach through data integration [PDF]
, 2013 Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels.
D'Amato, Mauro +6 more
core +1 more source
Biomedicines, 2022 Paclitaxel is a widely used anticancer drug that induces dose-limiting peripheral neuropathy. Mitochondrial dysfunction has been implicated in paclitaxel-induced neuronal damage and in the onset of peripheral neuropathy. We have previously shown that the
Hye-Ji Jang +4 more
doaj +1 more source
The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions [PDF]
, 2010 The preparation and application of groups of new iridium complexes are described. In particular, iridium complexes possessing phosphine ligands and a bulky N-heterocyclic carbene have been shown to be robust and readily handled species and have been ...
Atzrodt +42 more
core +1 more source
Pharmaceutics, 2021 We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule niclosamide that achieved a more than two-fold increase in bioavailability.
Miguel O. Jara +2 more
doaj +1 more source
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers. [PDF]
, 2016 Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers.
Ahmed, K. +3 more
core +3 more sources
Niclosamide in prostate cancer: An inhibitor of AR-V7, a mitochondrial uncoupler, or more?
Cancer Treatment and Research Communications, 2023 A recent phase Ib study investigating the use of reformulated niclosamide in combination with abiraterone and prednisone in patients with castration-resistant prostate cancer (CRPC) demonstrated encouraging preliminary efficacy with low toxicity ...
Minas Sakellakis
doaj +1 more source
Biotin-targeted Pluronic® P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells [PDF]
, 2016 With the aim to develop alternative therapeutic tools for the treatment of resistant cancers, here we propose targeted Pluronic1 P123/F127 mixed micelles (PMM) delivering niclosamide (NCL) as a repositioning strategy to treat multidrug resistant non ...
Budillon, Alfredo +10 more
core +1 more source
Niclosamide, a Drug with Many (Re)purposes [PDF]
ChemMedChem, 2018 AbstractNiclosamide is an anthelmintic drug that has been used for over 50 years mainly to treat tapeworm infections. However, with the increase in drug repurposing initiatives, niclosamide has emerged as a true hit in many screens against various diseases.
Hachemi Kadri +2 more
openaire +2 more sources