Results 71 to 80 of about 8,705 (221)
Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein [PDF]
, 2018 We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green ...
Annaert, Wim +6 more
core +1 more source
Niclosamide’s potential direct targets in ovarian cancer
Biology of Reproduction, 2021 Abstract Recent evidence indicates that niclosamide is an anti-cancer compound that is able to inhibit several signaling pathways. Although niclosamide has previously been identified by high-throughput screening platforms as a potential effective compound against several cancer types, no direct binding interactions with distinct ...
Nikola, Sekulovski +8 more
openaire +2 more sources
AntibioticsColistin is primarily used as a last resort antibiotic against highly resistant Gram-negative bacteria (GNB). Rising rates of colistin resistance, however, may limit future use of this agent.
Liam Berry +7 more
doaj +1 more source
Synthesis and biological evaluation of niclosamide PROTACs
Bioorganic & Medicinal Chemistry Letters, 2022 Roughly 268,000 new cases of prostate cancer and 34,000 deaths from prostate cancer are projected by the American Cancer Society to occur in the United States in 2022. Androgen receptor is a key protein in the proliferation and survival of prostate cancer cells and has been revealed to be overexpressed in 30% to 50% of castration-resistant prostate ...
Munoz, Erick +9 more
openaire +2 more sources
MedComm, Volume 7, Issue 4, April 2026.Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan +17 more
wiley +1 more source
Egyptian Journal of Aquatic Research, 2020 Controlled-release technology was introduced to offer an incredible guarantee for improving the adequacy of the existing active molecules and solving the related environmental troubles.
El-Refaie Kenawy +4 more
doaj +1 more source
Comparison of Disinfection Activities of Nicotine with Copper Sulphate in water Containing Limnatis nilotica [PDF]
, 2015 In this study, we investigated the potential use of nicotine in controlling water polluted by leeches. The nicotine and copper sulphate LC50 values were also determined following 30 min exposure.
Bahmani, M. +3 more
core +2 more sources
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, Volume 293, Issue 7, Page 2067-2085, April 2026.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Niclosamide in the treatment of tetagonimiasis
The Korean Journal of Parasitology, 1978 Anthelmintic effect of niclosamide [N-(2-chloro-4-nitrophenyl)-5-chloro-salicylamide)] on Metagonimus infection was carried out to the cases in area of Seomjin-river. The drug, one tablet contains 0.5 g of niclosamide was supplied from Bu-gwang pharmaceutical company in Seoul.
Yung Kyum, Ahn +2 more
openaire +2 more sources
Nature Communications, 2023 The dual functions of TMEM16F as Ca2+-activated ion channel and lipid scramblase raise intriguing questions regarding their molecular basis. Intrigued by the ability of the FDA-approved drug niclosamide to inhibit TMEM16F-dependent syncytia formation ...
Shengjie Feng +14 more
doaj +1 more source