Results 71 to 80 of about 4,650 (177)

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. [PDF]

PLoS ONE, 2011
The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target.
Wenyan Lu, Cuihong Lin, Michael J Roberts, William R Waud, Gary A Piazza, Yonghe Li   +5 more
doaj   +1 more source

Niclosamide ethanolamine inhibits artery constriction

Pharmacological Research, 2017
We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA.
Shan-Liang, Li, Jie, Yan, Yan-Qiu, Zhang, Chang-Lin, Zhen, Ming-Yu, Liu, Jing, Jin, Jin-Lai, Gao, Xiao-Lin, Xiao, Xin, Shen, Yu, Tai, Nan, Hu, Xin-Zi, Zhang, Zhi-Jie, Sun, De-Li, Dong   +13 more
openaire   +2 more sources

Niclosamide and its derivative DK‐520 inhibit RANKL‐induced osteoclastogenesis

FEBS Open Bio, 2020
Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK‐520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally.
Yurui Jiao, Chenglong Chen, Xijian Hu, Xu Feng, Zhenqi Shi, Jie Cao, Qing Li, Yikun Zhu   +7 more
doaj   +1 more source

NDUFS1‐Mediated Mitochondrial Complex I Activity Maintains Pancreatic Cancer Stemness by Promoting PAX2 Hypomethylation

MedComm, Volume 7, Issue 4, April 2026.
Pancreatic cancer stem cells (CSCs) maintain stemness and tumorigenicity through NDUFS1‐mediated complex I activity, which is transcriptionally upregulated via the CD147‐STAT3 signaling axis. Enhanced oxidative phosphorylation (OXPHOS) and NAD+ production driven by this CD147‐NDUFS1 axis subsequently trigger the SIRT1‐DNMT1 metaboloepigenetic signaling
Xin‐Yu Fan, Wen Li, Ying Shi, Bao‐Qing Xu, Hao Wang, Ruo‐Fei Tian, Zi‐Chuan Duan, Jing Fan, Jia‐Rong Liu, Xiu‐Xuan Sun, Bin Wang, Li‐Juan Wang, Ke Wang, Shi‐Jie Wang, Xiang‐Min Yang, Hong‐Yong Cui, Zhi‐Nan Chen, Ling Li   +17 more
wiley   +1 more source

Voltammetric Determination of Niclosamide

, 1991
Department of Chemistry, S. V. U. College of Engineering, Tirupati-517 502 Manuscript received 9 February 1990, revised 7 January 1991, accepted 8 May 1991 The electrochemical behaviour of niclosamide is described on the basis of the study carried out using d.c. polarography, cyclic voltammetry, a.c.
C. SRIDEVI, S. JAYARAMA REDDY
openaire   +2 more sources

Evaluation of concurrent use of Vitamin C and Niclosamide against methotrexate-induced liver injury in mice

Journal of the Pakistan Medical Association
Objective: To examine the effect of using vitamin C and niclosamide together on liver damage caused by methotrexate. Method: The study was conducted at the Pharmacology Department and the Iraqi Center for Cancer and Medical Genetics Research, College
Zainab Zeki, Ali Ismail Abdulla Al-Gareeb   +1 more
doaj   +1 more source

Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells

Acta Pharmaceutica Sinica B, 2018
Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler.
Yu Tai, Lanjun Li, Xuan Peng, Junxue Zhu, Xihai Mao, Nan Qin, Minghui Ma, Rong Huo, Yunlong Bai, Deli Dong   +9 more
doaj   +1 more source

Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: As the most lethal urological cancers, renal cell carcinoma (RCC) comprises a heterogeneous group of cancer with diverse genetic and molecular alterations. There is an unmet clinical need to develop efficacious therapeutics for advanced,
Xinyi Yu, Feng Liu, Liyi Zeng, Fang He, Ruyi Zhang, Shujuan Yan, Zongyue Zeng, Yi Shu, Chen Zhao, Xingye Wu, Jiayan Lei, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Xiaojuan Ji, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Yixiao Feng, Bo Huang, Wei Liu, Bo Zhang, Zhengyu Dai, Xi Wang, Bo Liu, Rex C. Haydon, Hue H. Luu, Hua Gan, Tong-Chuan He, Liqun Chen   +32 more
doaj   +1 more source

Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.

PLoS ONE
AimNiclosamide is an established anthelmintic substance and a promising candidate for treating cancer, viral infections, and other diseases. However, its solubility in aqueous media is low, and the systemic bioavailability of the commercially available ...
Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M Corman, Nils C Gassen, Marcel A Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G Posch   +9 more
doaj   +1 more source

“Niclosamide: A potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs)”

Heliyon
Pruritus is an uncomfortable sensation induced by various pruritogens, including serotonin. Serotonin, acting as an inflammatory mediator, can activate a histamine-independent pathway. Consequently, many anti-pruritus medications, such as antihistamines,
Zahra Ebrahim Soltani, Mohammad Elahi, Maziyar Askari Rad, Sara Farsio, Ahmad Reza Dehpour   +4 more
doaj   +1 more source