Results 81 to 90 of about 8,705 (221)

The anti-leech effect of ethanolic etract ofachillea millefolium l. Compared to levamisole and niclosamide on limnatis nilotica [PDF]

, 2014
This experimental trial was designed to evaluate the anti-Limnatis nilotica effect of Achillea millefolium L. ethanolic extract as well as levimisole and niclosamide. In an experimental study the extract of Achillea millefolium L.
Abdi, Fatemeh., Adineh, Ahmad., Bahmani, Mahmoud., Eghbali, Bahareh., Gholami-Ahangaran, Majid., Hassanzadazar, Hassan., Rafieian-Kopaei, Mahmoud.   +6 more
core  

From Synthesis to Therapeutics: Bioactive‐Coated Zein Nanoparticles in Drug Delivery

Biopolymers, Volume 117, Issue 2, March 2026.
ABSTRACT Polymeric zein nanoparticles (ZNP), derived from corn protein, are biodegradable drug carriers with high stability and low synthesis costs. Their amphiphilic nature allows efficient encapsulation of both hydrophilic and lipophilic drugs, making them promising for drug delivery.
Milena Ferreira de Lima, Andy Joel Taipe Huisa, Azael da Silva Neto, Clarice Beatriz Gonçalves Silva, Iago Dillion Lima Cavalcanti, Karolliny Barbosa de Araújo, Mariane Cajubá de Britto Lira‐Nogueira, Nereide Stela Santos Magalhães, Priscila Gubert   +8 more
wiley   +1 more source

Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line.

PLoS ONE, 2017
Glioblastoma is the most common and lethal malignant primary brain tumor for which the development of efficacious chemotherapeutic agents remains an urgent need.
Benxu Cheng, Liza Doreen Morales, Yonghong Zhang, Shizue Mito, Andrew Tsin   +4 more
doaj   +1 more source

Targeting the Wnt pathways for therapies [PDF]

, 2014
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance.
Blagodatski, A., Katanaev, V.L., Poteryaev, D.   +2 more
core   +1 more source

A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids

Journal of Lipid Research, 2009
Administered subcutaneously, D-4F or L-4F are equally efficacious, but only D-4F is orally efficacious because of digestion of L-4F by gut proteases. Orally administering niclosamide (a chlorinated salicylanilide used as a molluscicide, antihelminthic ...
Mohamad Navab, Piotr Ruchala, Alan J. Waring, Robert I. Lehrer, Susan Hama, Greg Hough, Mayakonda N. Palgunachari, G.M. Anantharamaiah, Alan M. Fogelman   +8 more
doaj   +1 more source

Frontiers of parasitology research in the People's Republic of China : infection, diagnosis, protection and surveillance [PDF]

, 2012
: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical modelling, monitoring, evaluation, surveillance and public ...
Bergquist, R., Chen, J. H., Chen, J. X., Tanner, M., Utzinger, J., Wang, H., Zhou, X. N.   +6 more
core   +2 more sources

Transcriptional regulation of human NMNAT2: insights from 3D genome sequencing and bioinformatics

The FEBS Journal, Volume 293, Issue 5, Page 1433-1458, March 2026.
NMNAT2 is a valuable drug target, as low levels increase the risk of neurodegeneration. We employed 4C‐seq to identify NMNAT2 regulatory regions in the human genome, revealing distinct interactomes of the NMNAT2 promoter in undifferentiated and neuron‐like SH‐SY5Y cells. Additionally, we uncovered NMNAT2‐associated genes and transcription factors. This
Yu Chen Chang, Sen Yang, Minyoung Cho, Kwangsik Nho, José‐Manuel Baizabal, Hui‐Chen Lu   +5 more
wiley   +1 more source

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han, Iris S. Weitz, Hasan Slika, Betty Tyler, Andrew J. Steckl   +4 more
wiley   +1 more source

The Impact of COVID‐19 on Obstructive Pulmonary Diseases: A Narrative Review of Long‐Term Consequences and Vaccination Strategies

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims The COVID‐19 pandemic has posed significant challenges for individuals with obstructive pulmonary diseases (OPDs), such as asthma and chronic obstructive pulmonary disease (COPD). Emerging evidence highlights the complex interplay between SARS‐CoV‐2 infection and OPDs, including increased risks of severe disease, long‐term ...
Behnam Dalfardi, Hamidreza Abtahi, Maryam Edalatifard, Sedigheh Mozaffari, Besharat Rahimi, Ghazal Roostaei, Niloofar Khoshnam Rad   +6 more
wiley   +1 more source

Niclosamide suppresses cancer cell growth by inducing Wnt co-receptor LRP6 degradation and inhibiting the Wnt/β-catenin pathway. [PDF]

PLoS ONE, 2011
The Wnt/β-catenin signaling pathway is important for tumor initiation and progression. The low density lipoprotein receptor-related protein-6 (LRP6) is an essential Wnt co-receptor for Wnt/β-catenin signaling and represents a promising anticancer target.
Wenyan Lu, Cuihong Lin, Michael J Roberts, William R Waud, Gary A Piazza, Yonghe Li   +5 more
doaj   +1 more source