Results 61 to 70 of about 8,705 (221)

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

mBio, 2020
One avenue to combat multidrug-resistant Gram-negative bacteria is the coadministration of multiple drugs (combination therapy), which can be particularly promising if drugs synergize.
Janine N. Copp, Daniel Pletzer, Alistair S. Brown, Joris Van der Heijden, Charlotte M. Miton, Rebecca J. Edgar, Michelle H. Rich, Rory F. Little, Elsie M. Williams, Robert E. W. Hancock, Nobuhiko Tokuriki, David F. Ackerley   +11 more
doaj   +1 more source

Dodecyl-TPP Targets Mitochondria and Potently Eradicates Cancer Stem Cells (CSCs): Synergy With FDA-Approved Drugs and Natural Compounds (Vitamin C and Berberine). [PDF]

, 2019
Elevated mitochondrial biogenesis and/or metabolism are distinguishing features of cancer cells, as well as Cancer Stem Cells (CSCs), which are involved in tumor initiation, metastatic dissemination, and therapy resistance.
De Francesco, EM, Lisanti, MP, Ozsvari, B, Sotgia, F   +3 more
core   +2 more sources

Antitumor effect and metabonomics of niclosamide micelles

Journal of Cellular and Molecular Medicine, 2022
AbstractPolymer micelles now have promising applications in the treatment of cancer, increasing the water solubility and bioavailability of drugs. Previous studies have found that micelles of niclosamide have good anti‐liver cancer effect. In view of the poor water solubility of niclosamide (NIC), we decided to prepare niclosamide micelles.
Jiarong Hang, Yu Chen, Lukuan Liu, Liwen Chen, Jiqin Fang, Fei Wang, Miao Wang   +6 more
openaire   +2 more sources

Niclosamide Blocks Rice Leaf Blight by Inhibiting Biofilm Formation of Xanthomonas oryzae

Frontiers in Plant Science, 2018
Rice (Oryza sativa) is the leading source of nutrition for more than half of the world’s population, and by far it is the most important commercial food crop. But, its growth and production are significantly hampered by the bacterial pathogen Xanthomonas
Sunil Kumar Sahu, Ping Zheng, Nan Yao
doaj   +1 more source

Human schistosomiasis [PDF]

, 2014
Human schistosomiasis-or bilharzia-is a parasitic disease caused by trematode fl ukes of the genus Schistosoma. By conservative estimates, at least 230 million people worldwide are infected with Schistosoma spp.
Bustinduy, Amaya L, Colley, Daniel G, King, Charles H, Secor, Evan   +3 more
core   +1 more source

Computational Design of an mRNA Vaccine Targeting LRP6 for Triple‐Negative Breast Cancer Therapy

Cancer Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background Triple‐negative breast cancer (TNBC) presents a poorer prognosis than other breast cancer subtypes, attributed to its aggressive nature and the lack of specific therapeutic interventions. TNBC has high recurrence rates and limited survival despite current therapies, emphasizing the critical need for improved treatment options.
Pooriya Teimoori, Mohammadreza Heidari
wiley   +1 more source

Niclosamide suppresses macrophage-induced inflammation in endometriosis† [PDF]

Biology of Reproduction, 2020
Abstract Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatments for endometriosis.
Nikola, Sekulovski, Allison E, Whorton, Tomoki, Tanaka, Yasushi, Hirota, Mingxin, Shi, James A, MacLean, Julio Ricardo Loret, de Mola, Kathleen, Groesch, Paula, Diaz-Sylvester, Teresa, Wilson, Kanako, Hayashi   +10 more
openaire   +2 more sources

Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça, Donald Seanego, Christopher Jurisch, Melina Mottin, Flávia Nader Motta, Beatriz S. A. Rodrigues, Gilberto S. M. Junior, Alexandra Maria dos Santos Carvalho, Fábio Muniz de Oliveira, Sunniva Sigurdardóttir, Per Sunnerhagen, Izabela Marques Dourado Bastos, Richard Gessner, Kelly Chibale, Carolina Horta Andrade   +14 more
wiley   +1 more source

A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells

Frontiers in Pharmacology, 2022
Aquaporin 5 (AQP5) is expressed in several cell types in the lung and regulates water transport, which contributes to barrier function during injury and the composition of glandular secretions.
John Villandre, John Villandre, Virginia White, Travis B. Lear, Travis B. Lear, Yanwen Chen, Ferhan Tuncer, Emily Vaiz, Beyza Tuncer, Karina Lockwood, Dan Camarco, Yuan Liu, Yuan Liu, Yuan Liu, Bill B. Chen, Bill B. Chen, Bill B. Chen, John Evankovich, John Evankovich   +18 more
doaj   +1 more source

Synergistic Activity of Niclosamide in Combination With Colistin Against Colistin-Susceptible and Colistin-Resistant Acinetobacter baumannii and Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2018
Colistin is among the few antibiotics effective against multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae clinical isolates. However, in the last few years, colistin-resistant A. baumannii and K.
Rafael Ayerbe-Algaba, María Luisa Gil-Marqués, Manuel Enrique Jiménez-Mejías, Viviana Sánchez-Encinales, Raquel Parra-Millán, María Eugenia Pachón-Ibáñez, Jerónimo Pachón, Jerónimo Pachón, Younes Smani   +8 more
doaj   +1 more source