Results 31 to 40 of about 8,705 (221)

Niclosamide methanol solvate and niclosamide hydrate: structure, solvent inclusion mode and implications for properties [PDF]

Acta Crystallographica Section C Structural Chemistry, 2014
Structural studies have been carried out of two solid forms of niclosamide [5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide, NCL], a widely used anthelmintic drug, namely niclosamide methanol monosolvate, C13H8Cl2N2O4·CH3OH or NCL·MeOH, and niclosamide monohydrate, denoted HA.
Harriss, Bethany, Wilson, Claire, Evans, Ivana R   +2 more
openaire   +3 more sources

Niclosamide for Covid-19: bridging the gap [PDF]

Molecular Biology Reports, 2021
Niclosamide (NCL) is an anthelminthic drug, which is widely used to treat various diseases due to its pleiotropic anti-inflammatory and antiviral activities. NCL modulates of uncoupling oxidative phosphorylation and different signaling pathways in human biological processes.
Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Khalid J. Alzahrani, Athanasios Alexiou, Gaber El-Saber Batiha   +4 more
openaire   +2 more sources

Inhibition of human immunodeficiency virus type 1 by niclosamide through mTORC1 inhibition

Heliyon, 2020
Niclosamide has been known to inhibit a number of pH-dependent viruses via the neutralization of endosomal acidic pH. It has also been shown to disrupt the mTORC1 signaling pathway. The replication of many viruses requires mTORC1 activation.
Nattamon Niyomdecha, Ornpreya Suptawiwat, Chompunuch Boonarkart, Kunlakunya Jitobaom, Prasert Auewarakul   +4 more
doaj   +1 more source

Presumed veterinary niclosamide-induced retinal toxicity in a human: a case report

Journal of Medical Case Reports, 2023
Background To report the first case of bull’s eye maculopathy associated with veterinary niclosamide. Case presentation A 27-year-old Iranian female presented with a history of reduced vision and photopsia since 3 years, after accidental ingestion of ...
Fatemeh Bazvand, Hamid Riazi-Esfahani, Farhad Salari   +2 more
doaj   +1 more source

Elimination of Schistosomiasis Transmission in Zanzibar: Baseline Findings before the Onset of a Randomized Intervention Trial. [PDF]

, 2013
Gaining and sustaining control of schistosomiasis and, whenever feasible, achieving local elimination are the year 2020 targets set by the World Health Organization.
A Fenwick, A Fenwick, AF Mgeni, Alan Fenwick, Anouk Gouvras, B Gryseels, B Lyons, BH Singer, BL Webster, Bobbie Person, CA Acka, CC Appleton, CH King, CJL Murray, CL Black, CM Gower, D Rollinson, D Rollinson, D Rollinson, David Rollinson, DJ Gray, E Emukah, EF Kjetland, F Allan, Fiona Allan, HD Mazigo, HD Mazigo, I Abbasi, I. Simba Khamis, IR Stothard, J Hamburger, J Utzinger, J Utzinger, J Utzinger, JM Spiegel, JR Mwanga, JR Mwanga, JR Stothard, JR Stothard, JR Stothard, JR Stothard, JR Stothard, JR Stothard, JW Rudge, Jürg Utzinger, KC Kosinski, Khalfan A. Mohammed, L Savioli, L Savioli, L Savioli, L Savioli, Lynsey Blair, M Giboda, MC Freeman, Muriel Rabone, P Steinmann, P Taylor, Patrick J. Lammie, PJ Hotez, PS Mbabazi, RF Sturrock, S Knopp, S Knopp, S Lustigman, Said M. Ali, Shaali M. Ame, Stefanie Knopp   +66 more
core   +4 more sources

Molecular mechanisms of niclosamide antitumor activity [PDF]

Biomeditsinskaya Khimiya, 2015
In this review the recent data regarding the antitumor activity of niclosamide and the molecular mechanisms of its antitumor activity are presented. Niclosamide has been used in the clinic for the treatment of intestinal parasite infections. In recent years in several screening investigations of various drugs and chemical compounds niclosamide was ...
E Yu, Moskaleva, V G, Perevozchikova, A S, Zhirnik, S E, Severin   +3 more
openaire   +2 more sources

Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice

Journal of Plant Protection Research, 2016
Bacterial leaf blight is one of the major diseases in rice and affects yields. Thus, various methods have been applied to protect rice from this disease.
Kim Sung-Il, Kwak Jun Soo, Song Jong Tae, Seo Hak Soo   +3 more
doaj   +1 more source

A strategy for emergency treatment of Schistosoma japonicum-infested water [PDF]

, 2011
Background Schistosomiasis japonica, caused by contact with Schistosoma japonicum cercaria-infested water when washing, bathing or production, remains a major public-health concern in China.
You-Sheng Liang, Wei Wang, Yun-Tian Xing, Hong-Jun Li, Yong-Liang Xu, Xue-Hui Shen, Guo-Li Qu, You-Zi Li, Jian-Rong Dai   +8 more
core   +2 more sources

Niclosamide Triggers Non-Canonical LC3 Lipidation [PDF]

Cells, 2019
Autophagy is a highly- evolutionarily-conserved catabolic pathway activated by various cellular stresses. Recently, non-canonical autophagy (NCA), which does not require all of the ATG proteins to form autophagosome or autophagosome-like structures, has been found in various conditions.
Liu, Yajun, Luo, Xia, Shan, Hao, Fu, Yuanyuan, Gu, Qianqian, Zheng, Xueping, Dai, Qi, Xia, Fan, Zheng, Zhihua, Liu, Peiqing, Yin, Xiao-Ming, Hong, Liang, Li, Min   +12 more
openaire   +3 more sources

Disturbances to energy metabolism in juvenile lake sturgeon (Acipenser fulvescens) following exposure to niclosamide

Ecotoxicology and Environmental Safety, 2022
Since the 1960s, invasive sea lamprey (Petromyzon marinus) populations in the Laurentian Great Lakes have been controlled by applying two chemicals, 3-trifluoromethyl-4-nitrophenol (TFM) and 2’,5-dichloro-4’-nitrosalicylanilide (niclosamide, aka ...
R. Adrian Ionescu, Dejana Mitrovic, Michael P. Wilkie   +2 more
doaj   +1 more source